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PKC

PKC

货号 产品名 CAS号 信息
CSN16722 Zoledronic Acid Monohydrate 165800-06-6 Zoledronic acid is an activator of protein kinase C with apoptotic effects on multiple myeloma cell lines.
CSN23775 VTX-27   1321924-70-2 VTX-27 is an inhibitor of protein kinase C θ (PKC θ) and PKC δ with Kis of 0.08 nM and 16 nM, respectively.
CSN23871 UCN-01 112953-11-4 UCN-01 is a selective inhibitor of protein kinase C.
CSN11980 Staurosporine   62996-74-1 Staurosporine is a prototypical potent ATP-competitive multikinase inhibitor with IC50 of 0.7, 7, 8.5, 6, 20 nM for PKC, PKA,PKG, p60v-src tyrosine protein kinase, CaM kinase II, respectively.
CSN17145 Sotrastaurin   425637-18-9 Sotrastaurin is a potent and selective pan-PKC inhibitor, mostly for PKCθ with Ki of 0.22 nM and inactive to PKCζ.
CSN23069 Ro 32-0432 151342-35-7 Ro 32-0432 is a selective and orally active inhibitor of protein kinase C prevents T-cell activation. It displays slight selectivity for conventional PKC isoforms over Ca2+ and atypical PKC isoforms; binding affinities for rat isoforms are 9, 28, 31, 37 and 108 nM for PKC's α, βΙ, βΙΙ, γ and ε respectively. Ro 32-0432 is orally available and prevents T cell chronic inflammation in vivo. ).
CSN11854 Ro 31-8220 Mesylate 138489-18-6 Ro 31-8220 mesylate is a pan-PKC inhibitor with IC50 of 5 nM, 24 nM, 14 nM, 27 nM, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively.
CSN17625 Ro 31-8220 125314-64-9 Ro 31-8220 is a pan-PKC inhibitor with IC50 of 5 nM, 24 nM, 14 nM, 27 nM, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively.
CSN23052 Prostratin 60857-08-1 Prostratin is a PKC and NF-κB activator.
CSN23246 Ro 32-0432 HCl 1781828-85-0 Potent, orally active PKC inhibitor
CSN25616 PKCβ Inhibitor 257879-35-9 PKCβ Inhibitor is a potent, reversible and ATP-competitive PKCβ inhibitor with IC50 values of 5nM and 21nM for PKCβII and βI, respectively.
CSN15884 PKC412 120685-11-2 PKC412 is a broad spectrum protein kinase inhibitor and inhibits conventional PKC isoforms (α, β, γ), PDFRβ, VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR.
CSN17423 PKC-IN-1 1046787-18-1 PKC-IN-1 is a poent PKC beta II inhibitor with Ki of 14.9 nM.
CSN23046 PKC β Pseudosubstrate 172308-76-8 PKC β Pseudosubstrate is a selective cell-permeable peptide inhibitor of protein kinase C with IC50 ~ 0.5 μM.
CSN11701 Phorbol 12-Myristate 13-Acetate 16561-29-8 Phorbol 12-myristate 13-acetate is a PKC-activating phorbol ester, increases the intracellular Ca2+ concentration ([Ca2+]i) in a dose-dependent manner, with an EC50 of 11.7 nM.
CSN13863 Phellopterin 2543-94-4 Phellopterin, a natural product isolated and purified from the roots of Saposhnikovia divaricata, is a partial agonist of the central benzodiazepine receptors in vitro, shows cytotoxic effect on RAW264.7 cell at the concentration from 40 to 400 μM, and reduces TNF-alpha-induced VCAM-1 expression through regulation of the Akt and PKC pathway, which contributes to inhibit the adhesion of monocytes to endothelium.
CSN18434 NSC 305787 785718-37-8 NSC305787 is a small molecule inhibitor of PKC, with IC50 of 8.3 μM, 9.4 μM, 55 μM for PKCΙ phosphorylation of recombinant ezrin, of moesin, and of radixin.
CSN18323 NSC 305787 HCl 53868-26-1 NSC305787 HCl is a small molecule inhibitor of PKC, with IC50 of 8.3 μM, 9.4 μM, 55 μM for PKCΙ phosphorylation of recombinant ezrin, of moesin, and of radixin.
CSN11485 Myricitrin 17912-87-7 Myricitrin, a flavonoid compound isolated from the root bark of Myrica cerifera, which exerts antinociceptive effects.
CSN12991 LY333531 HCl 169939-93-9 LY333531 is a β-specific protein kinase C inhibitor. It competitively and reversibly inhibits PKCβ1 and PKCβ2 with IC50 values of 4.7 and 5.9 nM respectively.
CSN20625 LXS196 1874276-76-2 LXS196 is a potent and orally active protein kinase C (PKC) inhibitor used for the treatment of uveal melanoma.
CSN21408 KAI-9803 949100-39-4 KAI-9803 is a potent and selective δ protein kinase C (δ PKC) inhibitor.
CSN14537 Isojacareubin 50597-93-8 Isojacareubin, a natural product isolated and purified from the roots of Garcinia fusca Pierre., is a potent inhibitor of protein kinase C (PKC), suppresses hepatocellular carcinoma metastasis and induces apoptosis in vitro and in vivo, thus, it as a promising lead compound for the development of antihepatoma agents, and displays potent activity against H.
CSN16020 Ingenol Mebutate 75567-37-2 Ingenol mebutate is a substance found in the sap of the plant Euphorbia peplus and an inducer of cell death.
CSN16527 Go6983   133053-19-7 Go6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ and PKCδ with IC50 of 7 nM, 7 nM, 6 nM and 10 nM, respectively and less potent to PKCζ and inactive to PKCμ.
CSN16571 Go6976 136194-77-9 Gö6976 is a pan inhibitor of Ca2+-dependent PKC isozymes, PKCα and PKCβ1, with IC50 values of 2.3nM and 6.2nM, respectively, but has no effect on Ca2+-independent PKC isozymes PKCδ, ε and ζ.
CSN10464 Bisindolylmaleimide I 133052-90-1 GF109203X is a potent PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ in cell-free assays, respectively, showing more than 3000-fold selectivity for PKC as compared to EGFR, PDGFR and insulin receptor.
CSN22823 FR 236924 28399-31-7 FR 236924 is a selective PKCε activator.
CSN12444 Enzastaurin 170364-57-5 Enzastaurin is a potent PKCβ selective inhibitor with IC50 of 6 nM, 6- to 20-fold selectivity against PKCα, PKCγ and PKCε.
CSN21985 Decursinol angelate 130848-06-5 Decursinol angelate (DA) blocks PGE2-induced activation of the EP2 receptor signaling pathway, including the activation of PKA and the phosphorylation of CREB.
CSN15402 Cycloheterophyllin 36545-53-6 Cycloheterophyllin, a natural product isolated and purified from the herbs of Artocarpus heterophyllus, exerts a concentration-dependent inhibition of neutrophil cytosolic protein kinase C (PKC) and rat brain PKC by the O2- generation in rat neutrophils, but has no effect on porcine heart protein kinase A (PKA).
CSN19868 Chelerythrine 34316-15-9 Chelerythrine, a natural product isolated and purified from the herbs of Chelidonium majus with potent antimanic, antiproliferatvie and antitumor effect, can inhibit telomerase activity, and is a well-known protein kinase C inhibitor.
CSN10607 Chelerythrine Chloride 3895-92-9 Chelerythrine Chloride is a potent, cell-permeable inhibitor of protein kinase C (IC50 = 660 nM) and competitive with respect to the phosphate acceptor and non-competitive with respect to ATP.
CSN17986 CGP-60474 164658-13-3 CGP60474 is a promising inhibitor of PKC with a high degree of selectivity versus other serine/threonine and tyrosine kinases and show competitive kinetics relative to ATP.
CSN22738 Calphostin C 121263-19-2 Calphostin C is a potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain with IC50 of 50 nM.
CSN20021 Bryostatin 1 83314-01-6 Bryostatin 1 is a Protein kinase C (PKC) activator that binds with high affinity (Ki = 1.35 nM).
CSN24270 Bisindolylmaleimide X HCl 145317-11-9 Bisindolylmaleimide xHCl is a potent protein kinase C (PKC) inhibitor.
CSN25331 Bisindolylmaleimide IV 119139-23-0 Bisindolylmaleimide IV is an inhibitor of protein kinase C.
CSN22715 Bisindolylmaleimide II 137592-45-1 Bisindolylmaleimide II is a potent, ATP-competitive protein kinase C (PKC) inhibitor with IC50 of 0.01 μM, and also a potent nAChR antagonist.
CSN11220 Acteoside 61276-17-3 Acteoside, is a natural product isolated and purified from the herbs of Cistanche deserticola Y.C. Ma with known antioxidant activity. It is a protein kinase C inhibitor (IC50 =25 μM).
CSN14800 20-Deoxyingenol 3-Angelate 75567-38-3 20-Deoxyingenol 3-angelate, a natural product isolated and purified from the aerial parts of Euphorbia peplus L., can induce significant platelet aggregation accompanied by induction of phosphorylation of PKC substrates in platelets, it is a protein kinase C (PKC) activator, and is known as promoters of tumors of mouse skin.
CSN16839 (-)-Indolactam V 90365-57-4 (-)-Indolactam V is a protein kinase C activator, which strongly directs human ES cell-derived definitive endoderm into pancreatic endoderm.
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