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Akt

Akt

货号 产品名 CAS号 信息
CSN10320 Triciribine 35943-35-2 Triciribine is a DNA synthesis inhibitor, also inhibits Akt and HIV-1/2 with IC50 of 130 nM, and 0.02-0.46 μM, respectively.
CSN16545 TIC10 Isomer 41276-02-2 TIC10 isomer is an isomer of TIC10, a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier.
CSN15801 TIC10 1616632-77-9 TIC10 is a brain-permeable and pharmacokinetics-improved Akt inhibitor, also inactivates ERK.
CSN22511 Solenopsin 137038-57-4 Solenopsin is an ATP-competitive AKT inhibitor with IC50 value of 10 μM .
CSN16878 SC79 305834-79-1 SC79 is a unique specific Akt activator that may be used to enhance Akt activity in various physiological and pathological conditions.
CSN18511 SC66 871361-88-5 SC66 is an allosteric and dual-inhibitory-function inhibitor of Akt which can lead to a reduction in total and phospho-AKT levels.
CSN16310 PHT-427 1191951-57-1 PHT-427 is dual inhibitor of Akt and PDPK1 with Ki of 2.7 μM and 5.2 μM, respectively, targeting PH domains of Akt and PDPK1.
CSN11682 Perifosine     157716-52-4 Perifosine is an Akt inhibitor with IC50 of 4.7 μM, targets pleckstrin homology domain of Akt.
CSN16135 Nitidine Chloride 13063-04-2 Nitidine Chloride can inhibit proliferation and induce apoptosis via the Akt pathway, derived from genus Zanthoxylum.
CSN15705 MK-2206 2HCl     1032350-13-2 MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively, showing no inhibitory activities against 250 other protein kinases observed.
CSN16767 Miltefosine 58066-85-6 Miltefosine is a mult-target inhibitor which can inhibit Akt, PI3K and PKC.
CSN17777 LY3023414 1386874-06-1 LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms, mTOR and DNA-PK with an IC50 of 64.9 nM, 42.1 nM, 10.6 nM, 19.1 nM for Akt1 (pT308), Akt1 (pS473), P70S6 (pT389), S6RP (pS240/242).
CSN13165 GSK690693 937174-76-0 GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes.
CSN13834 GSK2141795   1047634-65-0 GSK2141795 is a selective, ATP-competitive, and orally bioavailable Akt inhibitor with IC50 of 180 nM, 328 nM, and 38 nM for Akt 1, 2 and 3,
CSN17426 GSK2141795 HCl 1047635-80-2 GSK2141795 hydrochloride is a potent and selective pan-Akt inhibitor with IC50 values of 180 nM for Akt1, 328 nM for Akt2, and 38 nM for Akt3 respectively.
CSN17425 GSK2110183 1047634-63-8 GSK2110183 is an orally bioavailable, selective, ATP-competitive and potent pan-Akt inhibitor with IC50s of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively.
CSN19148 GSK2110183 HCl 2070009-64-0 GSK2110183 hydrochloride is an orally bioavailable, selective, ATP-competitive and potent pan-Akt inhibitor with IC50s of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively.
CSN15783 GDC-0068     1001264-89-6 GDC-0068 is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, 620-fold selectivity over PKA.
CSN17787 GDC-0068 2HCl 1396257-94-5 GDC-0068 dihydrochloride is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, 620-fold selectivity over PKA.
CSN13985 Deguelin 522-17-8 Deguelin is a naturally occuring Akt inhibitor purified from the herbs of Derris robusta, which downregulates Akt phosphorylation and shows anticancer effect.
CSN15730 CCT128930 885499-61-6 CCT128930 is a potent ATP-competitive, selective Akt2 inhibitor with an IC50 of 6 nM and > 28-fold selectivity for Akt2 than the closely related PKA kinase.
CSN18817 BAY1125976 1402608-02-9 BAY1125976 is a selective allosteric AKT1/2 inhibitor and inhibits AKT1 and AKT 2 activity with IC50 values of 5.2 nM and 18 nM at 10 μM ATP, respectively.
CSN13769 AZD5363     1143532-39-1 AZD5363 is a potent pan-AKT kinase inhibitor with IC50 of 3, 7 and 7 nM for Akt1,Akt2 and Akt3, respectively.
CSN16097 AT7867 857531-00-1 AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively, exhibiting little activity outside the AGC kinase family.
CSN17845 AT7867 2HCl 1431697-86-7 AT7867 hydrochloride is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively, and displaying little activity outside the AGC kinase family.
CSN13758 AT13148 1056901-62-2 AT13148 is an oral, ATP-competitive, multi-AGC kinase inhibitor with IC50 of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for Akt1/2/3, p70S6K, PKA, and ROCKI/II, respectively.
CSN17685 ARQ 092 Free Base 1313881-70-7 ARQ-092 is an orally bioavailable, selective, and potent allosteric Akt inhibitor with IC50 of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively.
CSN19250 ARQ 092 1313883-00-9 ARQ 092 is a pan-Akt inhibitor with IC50 values of 5nM, 4.5nM and 16nM for Akt1, Akt2 and Akt2, respectively, through blocking membrane translocation of inactive AKT and even dephosphorylating the membrane-associated active form.
CSN18535 Akt1 and Akt2-IN-1 893422-47-4 Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 (IC50 = 3.5 nM) and Akt2 (IC50 = 42 nM), with potent and balanced activity.
CSN18455 AKT Kinase Inhibitor 842148-40-7 AKT kinase inhibitor is a compound with potent Akt inhibition activity.
CSN17274 AKT Inhibitor 1004990-28-6 AKT inhibitor is a broadly selective, potent, ATP-competitive Akt inhibitor, displays 900-fold greater selectivity for PKBα (IC50 = 0.5 nM) than PKA (IC50=450 nM).
CSN17427 Afuresertib     1047644-62-1 Afuresertib is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively.
CSN15693 Afuresertib HCl 1047645-82-8 Afuresertib HCl is a potent pan-Akt inhibitor with Ki values of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively.
CSN16733 A-674563 552325-73-2 A-674563 is a potent selective Akt1 inhibitor with an IC50 of 14 nM. It also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively.
CSN19145 A-674563 HCl 2070009-66-2 A-674563 hydrochloride is a potent and selective Akt1 inhibitor with Ki of 11 nM.
CSN18330 A-443654 552325-16-3 A-443654 is a potent small-molecule inhibitor of all three Akt serine/threonine kinases, induces Akt Ser-473 phosphorylation in all human cancer cell lines tested, including PTEN- and TSC2-deficient lines.
CSN10945 3CAI 28755-03-5 3CAI is a potent allosteric and specific AKT inhibitor, which exerts efficacy in vitro and in vivo.
CSN14300 2'-Methoxykurarinone 270249-38-2
CSN14412 Hirsutenone 41137-87-5
CSN22684 API-1 36707-00-3
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