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Akt

Akt

货号 产品名 CAS号 信息
CSN10320 Triciribine 35943-35-2 Triciribine is a DNA synthesis inhibitor, also inhibits Akt and HIV-1/2 with IC50 of 130 nM, and 0.02-0.46 μM, respectively.
CSN16545 TIC10 Isomer 41276-02-2 TIC10 isomer is an isomer of TIC10, a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier.
CSN15801 TIC10 1616632-77-9 TIC10 is a brain-permeable and pharmacokinetics-improved Akt inhibitor, also inactivates ERK.
CSN22511 Solenopsin 137038-57-4 Solenopsin is an ATP-competitive AKT inhibitor with IC50 value of 10 μM .
CSN16878 SC79 305834-79-1 SC79 is a unique specific Akt activator that may be used to enhance Akt activity in various physiological and pathological conditions.
CSN18511 SC66 871361-88-5 SC66 is an allosteric and dual-inhibitory-function inhibitor of Akt which can lead to a reduction in total and phospho-AKT levels.
CSN16310 PHT-427 1191951-57-1 PHT-427 is dual inhibitor of Akt and PDPK1 with Ki of 2.7 μM and 5.2 μM, respectively, targeting PH domains of Akt and PDPK1.
CSN13863 Phellopterin 2543-94-4 Phellopterin, a natural product isolated and purified from the roots of Saposhnikovia divaricata, is a partial agonist of the central benzodiazepine receptors in vitro, shows cytotoxic effect on RAW264.7 cell at the concentration from 40 to 400 μM, and reduces TNF-alpha-induced VCAM-1 expression through regulation of the Akt and PKC pathway, which contributes to inhibit the adhesion of monocytes to endothelium.
CSN11682 Perifosine 157716-52-4 Perifosine is an Akt inhibitor with IC50 of 4.7 μM, targets pleckstrin homology domain of Akt.
CSN13651 Nortrachelogenin 34444-37-6 Nortrachelogenin, a natural product isolated and purified from the herbs of Trachelospermum jasminoides, shows effects on the central nervous system producing depression in rabbits and is an agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth factor receptors (GFRs), thereby efficiently synergizing with TRAIL exposure.
CSN16135 Nitidine Chloride 13063-04-2 Nitidine Chloride can inhibit proliferation and induce apoptosis via the Akt pathway, derived from genus Zanthoxylum.
CSN21078 M2698 1379545-95-5 MSC2363318A, also known as M2698, is an orally available inhibitor of the serine/threonine protein kinases ribosomal protein S6 Kinase (p70S6K) and Akt (protein kinase B), with potential antineoplastic activity.
CSN15705 MK-2206 2HCl   1032350-13-2 MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively, showing no inhibitory activities against 250 other protein kinases observed.
CSN16767 Miltefosine 58066-85-6 Miltefosine is a mult-target inhibitor which can inhibit Akt, PI3K and PKC.
CSN17777 LY3023414 1386874-06-1 LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms, mTOR and DNA-PK with an IC50 of 64.9 nM, 42.1 nM, 10.6 nM, 19.1 nM for Akt1 (pT308), Akt1 (pS473), P70S6 (pT389), S6RP (pS240/242).
CSN14412 Hirsutenone 41137-87-5 Hirsutenone, a natural product isolated and purified from the eaves of Alnus nepalensis, exhibits anti-cancer effect against prostate cancer through a direct physical inhibition of Akt1/2, attenuates adipogenesis by directly targeting PI3K and ERK during MCE in 3T3-L1 preadipocytes, underscoring the potential therapeutic application of Hirsutenone in preventing obesity, and may exert a preventive effect against microbial endotoxin lipopolysaccharide-induced inflammatory skin diseases through inhibition of ERK pathway-mediated NF-kappaB activation. Hirsutenone showed potent PL(pro) inhibitory activity with IC50 value of 4.1µM.
CSN13165 GSK690693 937174-76-0 GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes.
CSN13834 GSK2141795 1047634-65-0 GSK2141795 is a selective, ATP-competitive, and orally bioavailable Akt inhibitor with IC50 of 180 nM, 328 nM, and 38 nM for Akt 1, 2 and 3,
CSN17426 GSK2141795 HCl 1047635-80-2 GSK2141795 HCl is a potent and selective pan-Akt inhibitor with IC50 values of 180 nM for Akt1, 328 nM for Akt2, and 38 nM for Akt3 respectively.
CSN19148 GSK2110183 analog HCl 2070009-64-0 GSK2110183 HCl is an orally bioavailable, selective, ATP-competitive and potent pan-Akt inhibitor with IC50s of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively.
CSN17425 GSK2110183 analog 1047634-63-8 GSK2110183 analog is an analog of GSK2110183.
CSN15783 GDC-0068 1001264-89-6 GDC-0068 is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, 620-fold selectivity over PKA.
CSN17787 GDC-0068 2HCl 1396257-94-5 GDC-0068 2HCl is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, 620-fold selectivity over PKA.
CSN13985 Deguelin 522-17-8 Deguelin is a naturally occuring Akt inhibitor purified from the herbs of Derris robusta, which downregulates Akt phosphorylation and shows anticancer effect.
CSN25303 CCT128930 HCl   N/A CCT128930 is a potent ATP-competitive, selective Akt2 inhibitor with an IC50 of 6 nM and > 28-fold selectivity for Akt2 than the closely related PKA kinase.
CSN15730 CCT128930 885499-61-6 CCT128930 is a potent ATP-competitive, selective Akt2 inhibitor with an IC50 of 6 nM and > 28-fold selectivity for Akt2 than the closely related PKA kinase.
CSN18817 BAY1125976 1402608-02-9 BAY1125976 is a selective allosteric AKT1/2 inhibitor and inhibits AKT1 and AKT 2 activity with IC50 values of 5.2 nM and 18 nM at 10 μM ATP, respectively.
CSN13769 AZD5363 1143532-39-1 AZD5363 is a potent pan-AKT kinase inhibitor with IC50 of 3, 7 and 7 nM for Akt1,Akt2 and Akt3, respectively.
CSN16097 AT7867 857531-00-1 AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively, exhibiting little activity outside the AGC kinase family.
CSN17845 AT7867 2HCl 1431697-86-7 AT7867 HCl is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively, and displaying little activity outside the AGC kinase family.
CSN13758 AT13148 1056901-62-2 AT13148 is an oral, ATP-competitive, multi-AGC kinase inhibitor with IC50 of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for Akt1/2/3, p70S6K, PKA, and ROCKI/II, respectively.
CSN17685 ARQ 092 Free Base 1313881-70-7 ARQ-092 is an orally bioavailable, selective, and potent allosteric Akt inhibitor with IC50 of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively.
CSN19250 ARQ 092 1313883-00-9 ARQ 092 is a pan-Akt inhibitor with IC50 values of 5nM, 4.5nM and 16nM for Akt1, Akt2 and Akt2, respectively, through blocking membrane translocation of inactive AKT and even dephosphorylating the membrane-associated active form.
CSN22684 API-1 36707-00-3 API-1 is a selective Akt/PKB inhibitor and shows antitumor activity.
CSN18535 Akt1 and Akt2-IN-1 893422-47-4 Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 (IC50 = 3.5 nM) and Akt2 (IC50 = 42 nM), with potent and balanced activity.
CSN18455 AKT Kinase Inhibitor 842148-40-7 AKT kinase inhibitor is a compound with potent Akt inhibition activity.
CSN17274 AKT Inhibitor 1004990-28-6 AKT inhibitor is a broadly selective, potent, ATP-competitive Akt inhibitor, displays 900-fold greater selectivity for PKBα (IC50 = 0.5 nM) than PKA (IC50=450 nM).
CSN17427 Afuresertib 1047644-62-1 Afuresertib is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively.
CSN15693 Afuresertib HCl 1047645-82-8 Afuresertib HCl is a potent pan-Akt inhibitor with Ki values of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively.
CSN16733 A-674563 552325-73-2 A-674563 is a potent selective Akt1 inhibitor with an IC50 of 14 nM. It also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively.
CSN19145 A-674563 HCl 2070009-66-2 A-674563 HCl is a potent and selective Akt1 inhibitor with Ki of 11 nM.
CSN18330 A-443654 552325-16-3 A-443654 is a potent small-molecule inhibitor of all three Akt serine/threonine kinases, induces Akt Ser-473 phosphorylation in all human cancer cell lines tested, including PTEN- and TSC2-deficient lines.
CSN10945 3CAI 28755-03-5 3CAI is a potent allosteric and specific AKT inhibitor, which exerts efficacy in vitro and in vivo.
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