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Lignans

Lignans

货号 产品名 CAS号 信息
CSN14378 Yangambin 13060-14-5 Yangambin, a natural product isolated and purified from the leaves of Ocotea duckei Vattimo., is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF) and therefore constitutes a potential therapeutic agent in different shock states where abnormal PAF release is supposed to play an important role.
CSN14378 Yangambin 13060-14-5 Yangambin, a natural product isolated and purified from the leaves of Ocotea duckei Vattimo., is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF) and therefore constitutes a potential therapeutic agent in different shock states where abnormal PAF release is supposed to play an important role.
CSN14640 Wallichinine 125292-97-9 Wallichinine, a natural product isolated and purified from the stems of Piper wightii, shows inhibitory activity on platelet aggregation caused by platelet activating factor (PAF), significantly potentiates the effects of two ABCB1 substrates vincristine and doxorubicin on inhibition of growth, arrest of cell cycle and induction of apoptosis in ABCB1 overexpressing cancer cells, and the overexpression of ABCB1 in cancer cells is one of the main reasons of cancer multidrug resistance (MDR), suggesting that wallichinine with ABCB1 presents valuable clues for the development of MDR reversal reagents from natural products.
CSN13531 Syringaresinol-Di-O-Glucoside 66791-77-3 Syringaresinol-Di-O-Glucoside is a natural product which exhibits an antidiabetic and antioxidative effect on a streptozotocin‑induced mouse model of diabetes.
CSN14338 Syringaresinol Diacetate 1990-77-8 Syringaresinol diacetate is a natural product isolated and purified from the herbs of Liriodendron tulipifera.
CSN11910 Secoisolariciresinol 29388-59-8 Secoisolariciresinol, a natural product isolated and purified from the Heartwood of Podocarpus spicata, exerts a suppressive effect on the gain of body weight of mice fed a high-fat diet by inducing gene expression of adiponectin, resulting in the altered expression of various genes related to the synthesis and β-oxidation of fatty acids.
CSN14368 Secoisolariciresinol Monoglucoside 63320-67-2 Secoisolariciresinol monoglucoside is a natural product isolated and purified from Linum usitatissimum L. cv AC McDuff.
CSN14645 Schizandriside 71222-06-5 Schizandriside, a natural product isolated and purified from the leaves of Miconia rubiginosa with anti-inflammatory effect, shows significant cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines with inhibitory concentration (IC50) values of 3.26-8.89 uM, and has inhibitory activities against nitric oxide and prostaglandin E(2) production in IFN-γ- and lipopolysaccharide-stimulated RAW 264.7 cells.
CSN13949 Schisanhenol 69363-14-0 Schisanhenol, a natural compound solated from the fruits of Schisandra rubriflora, is a UGT2B7 UDP-glucuronosyltransferases inhibitor.
CSN14350 Savinin 493-95-8 Savinin, a natural product isolated and purified from the heartwood of Pterocarpus santalinus with antiinflammatory effect, can significantly inhibit tumor necrosis factor (TNF)-a production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells, and T cell proliferation elicited by concanavalin (Con A), without displaying cytotoxicity, and also exhibits potent spermicidal activity and significant insecticidal activity.
CSN14360 Randaiol 87562-14-9 Randaiol is a natural product isolated and purified from the barks of Magnolia hypoleuca.
CSN14335 R(+)-Gomisin M1 82467-50-3 R(+)-Gomisin M1 is a natural product isolated and purified from the fruits of Schizandra chinensis exhibiting potent anti-HIV activity, with EC50 and therapeutic index (TI) values of < 0.65 mM and > 68, respectively.
CSN14365 Piperenone 57625-31-7 Piperenone, a PAF-acether antagonist isolated and purified from the stems of Piper schmidtii Hook f., has anti-platelet-activating factor(PAF) activity.
CSN12281 Pinoresinol 487-36-5 Pinoresinol, a natural product isolated and purified from the bark of Eucommia ulmoides Oliver, may exert pharmacologically interesting effects via modulation of the insulin-like signalling pathway in C.
CSN14337 Pinoresinol Diacetate 32971-25-8 Pinoresinol diacetate, a natural product isolated and purified from the bark of Eucommia ulmoides Oliver, inhibits the enzyme α-glucosidase in vitro and may therefore act as a hypoglycemic agent.
CSN14349 Paulownin 13040-46-5 Paulownin, a natural product isolated and purified from the barks of Paulownia tomentosa, is active against the MCF-7 breast cancer cell line with IC50 values of 14.0 uM, and has the action of anti-inflammation, analgesia, immunity, hypoglycemia and has little toxicity.
CSN14344 Olivil 2955-23-9 Olivil, a natural product isolated and purified from the roots of Valeriana officinalis, displays a higher antioxidative effect against the free radical DPPH.
CSN13651 Nortrachelogenin 34444-37-6 Nortrachelogenin, a natural product isolated and purified from the herbs of Trachelospermum jasminoides, shows effects on the central nervous system producing depression in rabbits and is an agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth factor receptors (GFRs), thereby efficiently synergizing with TRAIL exposure.
CSN14342 Niranthin 50656-77-4 Niranthin, a natural product isolated and purified from the herbs of Phyllanthus amarus, exhibits anti-hepatitis B virus activity both in vitro and in vivo, and antiinflammatory and antiallodynic actions which are probably mediated through its direct antagonistic action on the PAF receptor binding sites.
CSN14342 Niranthin 50656-77-4 Niranthin, a natural product isolated and purified from the herbs of Phyllanthus amarus, exhibits anti-hepatitis B virus activity both in vitro and in vivo, and antiinflammatory and antiallodynic actions which are probably mediated through its direct antagonistic action on the PAF receptor binding sites.
CSN11353 Magnolin 31008-18-1 Magnolin, a natural product isolated and purified from the flowers of Magnolia biondii Pamp., reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro.
CSN14345 Liriodendrin 573-44-4 Liriodendrin, a natural product isolated and purified from the herbs of Linaria vulgaris, may be a potent suppressor of CaCl(2)-induced arrhythmias and can be utilized for the treatment and/or protection of gastritis and gastric ulcer. It also has anti-inflammatory and antinociceptive effects after oral administration.
CSN14346 Licarin A 51020-86-1 Licarin A, a natural product isolated and purified from Machilus thunbergii, is a candidate compound for the treatment of immediate hypersensitivity via inhibition of rat mast cell line RBL-2H3 cells.
CSN14339 Lariciresinol Dimethyl Ether 67560-68-3 Lariciresinol dimethyl ether is a natural product isolated and purified from the herbs of Rostellularia procumbens.
CSN14363 Kadsurin A 99340-07-5 Kadsurin A is a natural product isolated and purified from the fruits of Kadsura longipedunculata with anti-platelet activating factor activities.
CSN14356 Isotaxiresinol 26194-57-0 Isotaxiresinol, a natural product isolated and purified from the branch of Taxus wallichiana, may be useful for treatment of postmenopausal osteoporosis, especially for prevention of bone fracture induced by estrogen deficiency, and prevents d-GalN/LPS-induced hepatic injury by inhibiting hepatocyte apoptosis through the blocking of TNF-alpha and IFN-gamma production by activated macrophages and direct inhibition of the apoptosis induced by TNF-alpha.
CSN14121 Gomisin D 60546-10-3 Gomisin D is a natural product isolated and purified from the fruits of Schizandra chinensis.
CSN14362 Futoquinol 28178-92-9 Futoquinol, a natural product isolated and purified from the herbs of Piper kadsura with anti-neuroinflammatory activity, can potently inhibit NO production with an IC(50) value of 16.8 mM in microglia cells, and shows potent inhibition of PMA-induced ROS production in human polymorphonuclear neutrophils with IC(50) values 13.1 +/- 5.3 mM.
CSN14361 Fargesone A 116424-69-2 Fargesone A is a natural product isolated and purified from the flower of Magnolia fargesii, shows inhibitory effects on nitric oxide (NO) production in the lipopolysaccharide plus interferon-gamma activated-murine macrophage cell line, J774.1.
CSN14364 Eudesmin 526-06-7 Eudesmin, a natural product isolated and purified from the dry leaves of Haplophyllum perforatum Kar.et Kir.
CSN15668 DL-Syringaresinol 1177-14-6 DL-Syringaresinol, a natural product isolated and purified from the herbs of Liriodendron tulipifera, shows inhibitory activity of Helicobacter pylori motility with the IC50 value is 50 mg/mL, potently inhibit the proliferation of human promyelocytic HL-60 cells through G1 arrest and induction of apoptosis, induces vasorelaxation by enhancing NO production in endothelial cells via two distinct mechanisms, phosphatidylinositol 3-kinase/Akt- and (PLC)/Ca2+/CaMKKβ -dependent eNOS phosphorylation and Ca(2+)-dependent eNOS dimerization, and protects against hypoxia/reoxygenation-induced cardiomyocytes injury and death by destabilization of HIF-1α in a FOXO3-dependent mechanism.
CSN14117 Dihydroguaiaretic Acid 66322-34-7 Dihydroguaiaretic acid, a natural product isolated and purified from the aerial parts of Saururus chinensis.
CSN14635 Denudatin B 87402-88-8 Denudatin B, a natural product isolated and purified from the herbs of Kadsura coccinea, inhibits the aggregation and ATP release of washed rabbit platelets caused by platelet-activating factor (PAF) in a concentration-dependent manner, has nonspecific antiplatelet action at high concentration by inhibiting phosphoinositides breakdown induced by collagen and thrombin, relaxes vascular smooth muscle by inhibiting the Ca2+ influx through voltage-gated and receptor-operated Ca2+ channels and its effect to increase cGMP may enhance the vasorelaxation and shows potent 2, 2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) radical scavenging activity.
CSN19920 Dehydrodiisoeugenol 2680-81-1 Dehydrodiisoeugenol, a natural product isolated and purified from the seeds of Myristica fragrans Houtt.
CSN19920 Dehydrodiisoeugenol 2680-81-1 Dehydrodiisoeugenol, a natural product isolated and purified from the seeds of Myristica fragrans Houtt.
CSN14119 Dehydrodiconiferyl Alcohol 4263-87-0 Dehydrodiconiferyl alcohol, a natural product isolated and purified from the stems of Cucurbita moschata., shows anti-adipogenic and anti-lipogenic effects in 3T3-L1 cells and primary mouse embryonic fibroblasts, and can modulate the differentiation of Th17 and Th1 cells and suppress experimental autoimmune encephalomyelitis, it may be a potential candidate as an agent for the control of Th17 and Th1-mediated inflammatory diseases.
CSN14638 Cycloolivil 3064-05-9 Cycloolivil, a natural polyphenolic antioxidant isolated and purified from the herbs of Maytenus hookeri Loes.
CSN14366 Burchellin 38276-59-4 Burchellin, a natural product isolated and purified from the herbs of Ocotea cymbarum. with larvicidal activity, can interfer with the development cycle of the mosquito, where its strongest toxic effect is 100% mortality in larvae (L3) at concentrations ≥ 30 ppm, and has activity against Trypanosoma cruzi, by inducing trypomastigote death with IC(50)/24 h of 520 mM and 960 mM, respectively.
CSN14871 Boehmenan 57296-22-7 Boehmenan, a natural product isolated and purified from the herbs of Euphorbia hirta Linn., exhibits cytotoxicity against both Wnt-dependent (HCT116) and Wnt-independent (RKO) cells, and decreases the expression of full, cytosolic and nuclear β-catenin along with c-myc in STF/293 cells, suggesting that boehmenan may have inhibited the Wnt signal by decreasing β-catenin levels.
CSN19867 Asarinin 133-05-1 Asarinin, a natural product isolated and purified from the herbs of Asarum sieboldii Miq.
CSN14120 Angeloylgomisin H 66056-22-2 Angeloylgomisin H, a natural product isolated and purified from the fruits of Schizandra chinensis, shows moderate cytotoxic activities with IC50 values ranging from 100 to 200 ug/mL against MCF7, HEK293 and CAL27 cell lines and may present significant myocardial protective activity.
CSN13202 5-Allyl-3-Methoxy-6-Methyl-7-(3,4,5-Trimethoxyphenyl)bicyclo[3.2.1]oct-3-Ene-2,8-Dione 106894-43-3 5-Allyl-3-methoxy-6-methyl-7-(3,4,5-trimethoxyphenyl)bicyclo[3.2.1]oct-3-ene-2,8-dione is a natural product isolated and purified from the herbs of Cassia fistula.
CSN14369 1-Hydroxypinoresinol 1-O-Glucoside 81495-71-8 1-Hydroxypinoresinol 1-O-glucoside, a natural product isolated and purified from the rhizomes of Salvia miltiorrhiza, exhibits peroxynitrite, total ROS and DPPH radical scavenging activities with IC50 values of 3.23 +/- 0.04, 2.26 +/- 0.07 and 32.3 +/- 0.13 mM, respectively.
CSN13971 (±)-Pinoresinol 4263-88-1 (±)-Pinoresinol is a natural product isolated and purified from Eucommia ulmoides Oliv extract.
CSN13972 (-)-Syringaresinol 6216-81-5 (-)-Syringaresinol, a natural product isolated and purified from the rhizomes of Polygonatum kingianum, inhibits the proliferation of human promyelocytic HL-60 cells through G(1) arrest and induction of apoptosis, may be a potential chemotherapeutic agent for the treatment of cancer.
CSN14336 (-)-Pinoresinol 4-O-Glucoside 41607-20-9 (-)-Pinoresinol 4-O-glucoside is a natural product isolated and purified from orsythia suspensa.
CSN14370 (+)-Nortrachelogenin 61521-74-2 (+)-Nortrachelogenin, a natural product isolated and purified from the roots of Wikstroemia indica., shows effects on the central nervous system producing depression in rabbits, induces morphological deformation of P. oryzae mycelia with the MMDC value of 31.3 +/- 1.8 mM, and is moderately active against HIV-1 in vitro.
CSN14371 (+)-Matairesinol 148409-36-3 (+)-Matairesinol, a natural product isolated and purified from the roots of Wikstroemia indica., shows inhibition of the discoloration of yellowtail dark muscle and exhibits immunomodulatory activity.
CSN14343 (+)-Lyoniresinol 14464-90-5 (+)-Lyoniresinol, a natural product isolated and purified from the root of Vitex negundo with antioxidant effect, shows robust anti-melanogenic activity, decreases tyrosinase activity and melanin biosynthesis in B16F10 cells by activating ERK signaling, which downregulated MITF, tyrosinase, but not TRP-1 and TRP-2 protein expression.
CSN14367 (+)-Isolariciresinol 9'O-Glucoside 63358-12-3 (+)-Isolariciresinol 9'O-glucoside(+)-Isolariciresinol 9'O-glucoside is a natural product isolated and purified from plants.
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