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Notch

Notch

货号 产品名 CAS号 信息
CSN22137 tCFA15 220757-88-0 tCFA15 is a trimethyl cyclohexenonic long chain fatty alcohol containing 15 carbon atoms on the side chain, promotes the differentiation of neurons, and may regulates Notchsignaling.
CSN16909 Semagacestat 425386-60-3 Semagacestat is an inhibitor of γ-secretase. It inhibits Aβ42, Aβ38, Aβ40 and the Notch signaling with IC50 of 10 nM, 12 nM, 12.1 nM and 14.1 nM.
CSN27258 SAHM1 2050906-89-1 SAHM1 is a stabilized hydrocarbon-stapled alpha helical peptide targeting Notch pathway. It mimics a dominant negative form of MAML, inhibits canonical Notch transcription complex formation.
CSN27582 2-(2-Fluorophenoxy)-4-(1-methyl-1H-pyrazol-5-yl)benzamide 2682114-39-0 RIN1 is a new class of small molecule inhibitor that disrupts the interaction between NOTCH and RBPJ. It also blocked the functional interaction of RBPJ with SHARP, a scaffold protein that forms a transcriptional repressor complex with RBPJ in the absence of NOTCH signaling.
CSN14398 Medicarpin 32383-76-9 Medicarpin, a natural product isolated and purified from the herb of Hedysarum polybotrys Hand. Heals Cortical Bone Defect by Activation of Notch and Wnt Canonical Signaling Pathways.
CSN15691 Crenigacestat 1421438-81-4 LY3039478 is a novel, potent Notch inhibitor with an IC50 of 0.41 nM.
CSN18826 IMR-1A 331862-41-0 IMR-1A is the metabolite of IMR-1, a Notch inhibitor targeting the transcriptional activation.
CSN18825 IMR-1 310456-65-6 IMR-1 is a cell penetrant and potent inhibitor of Notch transcriptional activation complex with IC50 of 6 μM for targeting the transcriptional activation.
CSN18205 FLI-06 313967-18-9 FLI-06 is a Notch signaling inhibitor with EC50 of 2.3 μM which can disrupt Notch trafficking and processing.
CSN27670 6-(4-(tert-Butyl)phenoxy)pyridin-3-amine 218457-67-1 CB-103 is a first-in-class orally active pan-notch signaling pathway inhibitor extracted from patent US9296682B2 with anti-tumor activity.
CSN17939 BMS-983970 1584713-87-0 BMS-983970 is an oral pan-Notch inhibitor for the treatment of cancer.
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