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ALK

ALK

货号 产品名 CAS号 信息
CSN20579 TPX-0005 1802220-02-5 TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 5.3 nM, 1.01 nM, 1.26 nM and 1.08 nM for SRC, WT ALK, ALK G1202R and ALK L1196M, respectively.
CSN22607 TP0427736 HCl N/A TP0427736 HCl is the hydrochloride form of TP0427736 which is an inhibitor of ALK5 with IC50 of 2.72 nM and can reduce TGF-β induced growth.
CSN22508 SM 16 614749-78-9 SM 16 is an an ATP-competitive ALK5/ALK4 inhibitor with IC50 value between 160 and 620 nM for inhibition of TGF-β1-induced Smad2/3 phosphorylation in cell study.
CSN15922 PF-06463922 1454846-35-5 PF-06463922 is an orally available, CNS-penetrant, ATP-competitive inhibitor of ALK/ROS1 with Ki of < 0.02 nM, < 0.07 nM, and 0.7 nM for ROS1, ALK (WT), and ALK (L1196M), respectively.
CSN12422 NVP-TAE 684 761439-42-3 NVP-TAE684 is a potent and selective ALK inhibitor with IC50 of 3 nM in a cell-free assay, 100-fold more sensitive for ALK than InsR.
CSN16207 LDK378 2HCl 1380575-43-8 LDK378 2HCl is a selective ALK inhibitor with an IC50 of 0.2 nM, and also inhibits InsR, IGF-1R, STK22D, FLT3 and FGFR2 with IC50 values of 7 nM, 8 nM, 23 nM, 60 nM and 260 nM.
CSN21367 JH-VIII-157-02 1639422-97-1 JH-VIII-157-02 is a structural analogue of alectinib, acts as an ALK inhibitor, and shows an IC50 of 2 nM for echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) G1202R in cells.
CSN17746 HG-14-10-04 1356962-34-9 HG-14-10-04 is a potent and specific ALK inhibitor with IC50 of 20 nM.
CSN17470 Entrectinib 1108743-60-7 Entrectinib is an oral pan-Trk, ROS1, and ALK inhibitor, with IC50 of 1.7/0.1/0.1 nM, 0.2 nM, and 1.6 nM for Trk A/B/C, ROS1, and ALK, respectively.
CSN18668 X-376 1365267-27-1 Ensartinib is a potent inhibitor ofALK, which is used to treat non-small-cell lung cancer.
CSN22549 Ensartinib 1370651-20-9 Ensartinib is a novel, potent anaplastic lymphoma kinase (ALK) small molecule tyrosine kinase inhibitor (TKI) with additional activity against MET, ABL, Axl, EPHA2, LTK, ROS1 and SLK. ALK autophosphorylation is significantly diminished by X-396, albeit at higher concentrations required to block autophosphorylation of the wild-type fusion.
CSN12319 Crizotinib     877399-52-5 Crizotinib is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM, respectivley.
CSN13803 Crizotinib HCl 1415560-69-8 Crizotinib hydrochloride is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM, respectivley.
CSN15842 CH5424802 HCl 1256589-74-8 CH5424802 hydrochloride is a potent ALK inhibitor with IC50 of 1.9 nM, sensitive to L1196M mutation.
CSN15775 Ceritinib 1032900-25-6 Ceritinib is potent inhibitor against ALK with IC50 of 0.2 nM, shows 40- and 35-fold selectivity against IGF-1R and InsR, respectively.
CSN19158 CEP-28122 Mesylate 1431697-88-9 CEP-28122 mesylate is a highly potent and selective orally active ALK inhibitor with IC50 of 1.9 ± 0.5 nM in an enzyme-based TRF assay.
CSN16925 CEP-28122 1022958-60-6 CEP-28122 is a highly potent and selective orally active ALK inhibitor with IC50 of 1.9 ± 0.5 nM in an enzyme-based TRF assay.
CSN17547 Brigatinib 1197953-54-0 Brigatinib is a selective ALK inhibitor with IC50 value of 0.37nM, and also inhibits ROS1, FLT3, FLT3-D835Y mutant and EGFR less potently.
CSN22546 Belizatinib 1357920-84-3 Belizatinib is a selective ALK inhibitor with IC50 value of 0.7nM, as well as shows potency against TRK A, B, and C with IC50 values<3nM.
CSN15910 AZD3463 1356962-20-3 AZD3463 is an orally bioavailable ALK inhibitor with Ki of 0.75 nM, which also inhibits IGF1R with equivalent potency.
CSN17127 ASP3026 1097917-15-1 ASP3026 is a selective inhibitor for ALK with IC50 of 3.5 nM.
CSN16870 ALK-IN-1 1197958-12-5 AP26113 is an analog of AP26113 which is a potent and selective ALK inhibitor. It is also an inhibitor of EGFR.
CSN19724 ALK Inhibitor C29 2093414-37-8 ALK inhibitor C29 shows promising anti-ALK activities in enzymatic- and cell-based assays, while in vivo H3122 xenograft model study showed that it effectively suppressed ALK-driven tumor growth.
CSN18423 ALK Inhibitor 2 761438-38-4 ALK inhibitor 2 is a selective inhibitor for the ALK kinase.
CSN18422 ALK Inhibitor 1 761436-81-1 ALK inhibitor 1 is a selective inhibitor for the ALK kinase.
CSN13474 Alectinib   1256580-46-7 Alectinib is a potent ALK inhibitor with IC50 of 1.9 nM while also inhibits F1174L, R1275Q, and L1196M mutants of ALK (IC50s = 1.0, 3.5, and 1.6 nM, respectively).
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