400-920-2911 sales@csnpharm.cn
您的位置 : 首页 / Metabolic Enzyme / Cathepsin / MG-101/钙蛋白酶抑制剂I
CAS No.: 110044-82-1
Synonyms: Calpain inhibitor I;Ac-LLnL-CHO;ALLN
MG-101 is a potent inhibitor of cysteine proteases including calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM).
生物活性
实验方案
技术信息
CAS号 | 110044-82-1 | 储存条件 |
|
|
分子式 | C20H37N3O4 | 运输 | 蓝冰 | |
分子量 | 383.53 | 别名 | Calpain inhibitor I;Ac-LLnL-CHO;ALLN;Calpain Inhibitor-1;Ac-Leu-Leu-Nle-Aldehyde |
Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
---|
HEK293 cells | - | Function assay | - | Effect on cofilin1 expressed in HEK293 cells assessed as effect on cofilin1; Limk2 interaction complexes by EYFP and/or YFP Venus fragment based reporter gene assay | 16680159 |
HeLa cells | - | Cytotoxicity assay | 48 h | Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTS assay, CC50=25.1 μM | 23357632 |
L1210 cells | - | Function assay | - | Inhibitory concentration of the compound was determined against L1210 cells, IC50=3 μM | 15634028 |
melanoma B16 cells | - | Function assay | - | Inhibitory concentration of the compound was determined against melanoma B16 cells, IC50=14.5 μM | 15634028 |
联系我们
官方电话:400-920-2911
二维码
微信公众号 CSN官网