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CAS No.: 67747-09-5

咪鲜胺 Catalog No. CSN27360

Synonyms: 咪鲜胺;BTS 40542;敌草胺

Prochloraz is an imidazole antifungal that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death. Prochloraz inhibits human placenta microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an antagonist of the estrogen receptor (ER) and androgen receptor (AR) (IC50s = 25 μM and 4 μM, respectively) as well as activates the aryl hydrocarbon receptor (AhR; EC50 = 1 μM).

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技术信息

生物活性

描述Prochloraz is an imidazole antifungal that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death. Prochloraz at 0.005 and 0.01 mg/liter disrupted cell membrane integrity of conidia but reduced cell membrane permeability of mycelia. Prochloraz at 0.01 mg/liter reduced ergosterol content in mycelia by 41.8%^[1]. Prochloraz antagonizes the androgen and the oestrogen receptor, agonizes the Ah receptor and inhibits aromatase activity. In vivo prochloraz acts as an antiandrogen in the Hershberger assay by reducing weights of reproductive organs, affecting androgen-regulated gene expressions in the prostate and increasing luteinizing hormone levels^[2]. Prochloraz at 0.01 and 0.04 µg/ml significantly (P < 0.001) reduced rather than increased cell membrane permeability. Prochloraz significantly (P = 0.041) increased the mannan content in the cell wall of S. sclerotiorum. The observed mycelial growth inhibitions for the mixtures of prochloraz at 0.03 µg/ml and Congo red at a dose range from 0.05 to 0.4% (w/v) were lower than the expected inhibitions, indicating prochloraz might reduce the content of chitin in S. sclerotiorum^[3]. Prochloraz administered alone is able to trigger oocyte maturation through the induction of specific genes, some of them being also triggered by LH(Luteinizing Hormone) ^[4].
参考文献

[1] Zhang Y, Zhang B, Luo C, Fu Y, Zhu F. Fungicidal Actions and Resistance Mechanisms of Prochloraz to Penicillium digitatum. Plant Dis. 2021 Feb;105(2):408-415
[2] Vinggaard AM, Hass U, Dalgaard M, Andersen HR, Bonefeld-Jørgensen E, Christiansen S, Laier P, Poulsen ME. Prochloraz: an imidazole fungicide with multiple mechanisms of action. Int J Androl. 2006 Feb;29(1):186-92
[3] Zhang R, Xu Q, Zhang Y, Zhu F. Baseline Sensitivity and Toxic Actions of Prochloraz to Sclerotinia sclerotiorum. Plant Dis. 2018 Nov;102(11):2149-2157
[4] Rime H, Nguyen T, Bobe J, Fostier A, Monod G. Prochloraz-induced oocyte maturation in rainbow trout (Oncorhynchus mykiss), a molecular and functional analysis. Toxicol Sci. 2010 Nov;118(1):61-70

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.6549 mL
- 13.2744 mL
- 26.5488 mL
- 5 mM
- 0.5310 mL
- 2.6549 mL
- 5.3098 mL
- 10 mM
- 0.2655 mL
- 1.3274 mL
- 2.6549 mL

技术信息

CAS号	67747-09-5	储存条件	粉末 Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C15H16Cl3N3O2	运输	蓝冰
分子量	376.67	别名	咪鲜胺;BTS 40542;敌草胺

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