生物活性

• 描述ORM-15341 is a potent and full antagonist for human AR (hAR) with IC50 values of 38 nM as shown by transactivation assays in AR-HEK293 cells stably expressing full-length hAR and an androgen-responsive luciferase reporter gene construct.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT02418650	Healthy	Phase 1	Completed	-	United Kingdom ... more >> Quotient Clinical Nottingham, United Kingdom, NG11 6JS Collapse <<
  NCT01317641	Prostate Cancer	Phase 1 Phase 2	Completed	-	United States, Colorado ... more >> The Urology Center of Colorado Wheat Ridge, Colorado, United States, 80211 United States, Connecticut Eastern CT Hematology and Oncology Associates Norwich, Connecticut, United States, 06360 United States, Florida Urology Health Team PLLC Ocala, Florida, United States, 34474 United States, Maryland Chesapeake Urology Research Associates Baltimore, Maryland, United States, 21327 United States, New Jersey Delaware Valley urology, LLC Voorhees, New Jersey, United States, 08043 United States, New York Brooklyn Urology Research Group Brooklyn, New York, United States, 11215 United States, Ohio Cleveland Clinic Cleveland, Ohio, United States, 44195 United States, South Carolina Carolina Urologic Research Center Myrtle Beach, South Carolina, United States, 29572 Czech Republic Klinika onkologie a radioterapie LFUK a FN Hradec Králové, Czech Republic Fakultni Nemonicnice Olomouc Olomouc, Czech Republic Oddeleni Radiacni a Klinicke Onkologie Nemocnice Znojmo Znojmo, Czech Republic Estonia East-Tallinn Central Hospital Talinn, Estonia Finland Helsinki University Central Hospital Helsinki, Finland Kuopio University Hospital Kuopio, Finland Oulu University Hospital Oulu, Finland Tampere University Hospital Tampere, Finland Turku University Hospital Turku, Finland France Saint Louis Hospital Paris, France Institut Gustave Roussy Villejuif, France United Kingdom Queen Elizabeth Hospital Birmingham, United Kingdom Velindre Cancer Centre Cardiff, United Kingdom Christie Hospital Manchester, United Kingdom Churchill Hospital Oxford, United Kingdom Collapse <<
  NCT02894385	Pharmacokinetics ... more >> Hepatic Insufficiency Renal Insufficiency Collapse <<	Phase 1	Completed	-	Germany ... more >> Kiel, Schleswig-Holstein, Germany, 24105 Lübeck, Germany, 23538 Collapse <<

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