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CAS No.: 960374-59-8
Synonyms: PR-957
ONX-0914 is 20- to 40-fold more selective for LMP7 over the next most sensitive sites, β5 or LMP2.
生物活性
实验方案
技术信息
CAS号 | 960374-59-8 | 储存条件 |
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分子式 | C31H40N4O7 | 运输 | 蓝冰 | |||||||||||
分子量 | 580.67 | 别名 | PR-957 | |||||||||||
溶解度 |
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动物实验配方 |
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Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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human Raji cells | - | Function assay | - | Inhibition of proteasome subunit beta-5i in human Raji cells using BODIPY-NC005 by fluorescent densitometry, IC50=5.7 nM | 25006746 |
human Raji cells | - | Function assay | - | Inhibition of 20s proteasome subunit beta-5c in human Raji cells using BODIPY-NC005 by fluorescent densitometry, IC50=0.054 μM | 25006746 |
human Raji cells | - | Function assay | - | Inhibition of proteasome subunit beta-1i in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry, IC50=0.46 μM | 25006746 |
human Raji cells | - | Function assay | - | Inhibition of proteasome subunit beta-2i in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry, IC50=0.59 μM | 25006746 |
human Raji cells | - | Function assay | - | Inhibition of 20s proteasome subunit beta-2c in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry, IC50=1.1 μM | 25006746 |
human RPMI8226 cells | - | Function assay | - | Inhibition of proteasome subunit beta-5i in human RPMI8226 cells using BODIPY-NC005 by fluorescent densitometry, IC50=0.018 μM | 25006746 |
human RPMI8226 cells | - | Function assay | - | Inhibition of 20s proteasome subunit beta-5c in human RPMI8226 cells using BODIPY-NC005 by fluorescent densitometry, IC50=0.18 μM | 25006746 |
human RPMI8226 cells | - | Function assay | - | Inhibition of proteasome subunit beta-1i in human RPMI8226 cells using BODIPY-NC001 by fluorescent densitometry, IC50=0.34 μM | 25006746 |
human RPMI8226 cells | - | Function assay | - | Inhibition of proteasome subunit beta-2i in human RPMI8226 cells using BODIPY-epoxomicin by fluorescent densitometry, IC50=0.59 μM | 25006746 |
human RPMI8226 cells | - | Function assay | - | Inhibition of 20s proteasome subunit beta-2c in human RPMI8226 cells using BODIPY-epoxomicin by fluorescent densitometry | 25006746 |
靶点 | Description | IC50 |
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