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DNA/RNA Synthesis
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN16911 | YK-4-279 | 1037184-44-3 | YK 4-279 is a potent inhibitor of RNA Helicase A (RHA) that binding to the oncogenic transciption factor EWS-FLI1. |
| CSN16802 | Vidarabine | 5536-17-4 | Vidarabine is an antiviral drug effects by interfering with the synthesis of viral DNA, which is used in treatment of herpes simplex and varicella zoster viruses. |
| CSN12159 | Tubercidin | 69-33-0 | Tubercidin, obtained from Streptomyces tubercidicus, is an adenosine analogue, is a nucleoside antibiotic. Also exhibits antifungal and antiviral activities. |
| CSN13562 | Triapine | 143621-35-6 | Triapine is a ribonucleotide reductase inhibitor and a CDK inhibtor. |
| CSN15880 | Tosufloxacin Tosylate | 115964-29-9 | Tosufloxacin tosylate is an antibacterial agent that inhibits bacterial DNA gyrase inhibitor. |
| CSN17977 | TH287 HCl | 1638211-05-8 | TH287 HCl is a potent inhibitor of MTH1 (NUDT1) with an IC50 value of 0.8 nM, less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16. |
| CSN12039 | Tegafur | 17902-23-7 | Tegafur is a prodrug of 5-fluorouraci 5-FU, is used in the treatment of cancers. |
| CSN15712 | (S)-Isopropyl 2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate | 1190307-88-0 | Sofosbuvir is an investigational nucleotide analog and a HCV NS5B polymerase inhibitor for treatment of chronic HCV infection. |
| CSN15758 | SCR7 pyrazine | 14892-97-8 | SCR7 pyrazine is a specific DNA ligase IV inhibitor, which blocks nonhomologous end-joining (NHEJ). |
| CSN15756 | SCR7 | 1533426-72-0 | SCR7 is an inhibitor of DNA Ligase IV, it inhibits joining of DSBs in cell-free repair system and inhibits NHEJ (nonhomologous end-joining) in a Ligase IV-dependent manner within cells, and activates the intrinsic apoptotic pathway. |
| CSN11845 | (2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-25-(Acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione | 80621-81-4 | Rifaximin is an RNA synthesis inhibitor by binding the β subunit of the bacterial DNA-dependent RNA polymerase, used to treat traveler's diarrhea caused by certain bacteria. |
| CSN11844 | Rifapentine | 61379-65-5 | Rifapentine is an antibiotic compound, which inhibits DNA-dependent RNA polymerase activity, used to treat tuberculosis. |
| CSN16146 | 8-(n-(4-methyl-1-piperazinyl)formidoyl)-rifomycins | 13292-46-1 | Rifampicin is a bacterial RNA polymerase inhibitor used in the treatment of bacterial infections. |
| CSN18725 | Rbin-1 | 328023-11-6 | Rbin-1 inhibits ATPase with GI50 of 136±7 nM, it is a potent, reversible, and specific chemical inhibitor of eukaryotic ribosome biogenesis. |
| CSN11595 | 5-Ethyl-8-oxo-5,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid | 14698-29-4 | Oxolinic acid is a potent inhibitor of DNA gyrase and DNA synthesis, lead to DNA cleavage when extracted chromosomes are incubated with sodium dodecyl sulfate. |
| CSN16103 | Nelarabine | 121032-29-9 | Nelarabine is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells. |
| CSN17838 | ML216 | 1430213-30-1 | ML216 is a potent inhibitor of the DNA unwinding activity of BLM helicase, showing similar IC50s of 3.0 and 0.97 μM for full length BLM and BLM636–1298 respectively. |
| CSN11454 | 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-hydroxy-1H-imidazole-4-carboxamide | 50924-49-7 | Mizoribine is an immunosuppressive agents (IC50=100 μM) that inhibit the proliferation of lymphocytes selectively, via inhibition of IMPDH. |
| CSN17932 | 5-(1H-Pyrazol-4-yl)-2-(6-((2,2,6,6-tetramethylpiperidin-4-yl)oxy)pyridazin-3-yl)phenol | 1562338-42-4 | LMI070 is a highly potent, selective and orally active small molecule SMN2 splicing modulator. |
| CSN18212 | L67 | 325970-71-6 | L67 is a competitive human DNA ligase inhibitor, inhibits DNA ligases I and III with IC50 of 10 μM and 10 μM. |
| CSN15759 | L189 | 64232-83-3 | L189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV with IC50 of 5/9/5 μM. |
| CSN16113 | N-(Aminocarbonyl)hydroxylamine | 127-07-1 | Hydroxyurea is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. |
| CSN11136 | Halofuginone | 55837-20-2 | Halofuginone is an inhibitor of prolyl-tRNA synthetase with Ki of 18.3 nM.It could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/mL in mammal. |
| CSN11086 | 4-Amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one | 95058-81-4 | Gemcitabine is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively. |
| CSN16647 | 4-Amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one hydrochloride | 122111-03-9 | Gemcitabine HCl is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively. |
| CSN16461 | ((2R,3S,4S,5R)-5-(6-Amino-2-fluoro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate | 75607-67-9 | Fludarabine phosphate is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis. |
| CSN18715 | 5-Fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione | 50-91-9 | Floxuridine is an oncology drug that belongs to antimetabolites with an GI50 of 5.1 μM for the inhibition of PEPT1. |
| CSN17043 | (2R,3S,4S,5S,6R)-6-(((3E,5E,8S,9E,11S,12R,13E,15E,18S)-12-(((2R,3S,4R,5S)-3,4-Dihydroxy-5-(isobutyryloxy)-6,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-11-ethyl-8-hydroxy-18-((R)-1-hydroxyethyl)-9,13,15-trimethyl-2-oxooxacyclooctadeca-3,5,9,13,15-pentaen-3-yl)methoxy)-4-hydroxy-5-methoxy-2-methyltetrahydro-2H-pyran-3-yl 3,5-dichloro-2-ethyl-4,6-dihydroxybenzoate | 873857-62-6 | Fidaxomicin is a macrocyclic antibiotic drug that inhibits RNA polymerase sigma subunit, and shows selective eradication of pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that make up the normal, healthy intestinal flora. |
| CSN12666 | 6-Fluoro-3-oxo-3,4-dihydropyrazine-2-carboxamide | 259793-96-9 | Favipiravir is an anti-viral compound with activity against many RNA viruses and an RNA-directed RNA polymerase NS5B inhibitor. |
| CSN18804 | E3330 | 136164-66-4 | E3330 is a potent and selective APE1 (Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity. |
| CSN18773 | CRT0044876 | 6960-45-8 | CRT0044876 is a potent and selective APE1 inhibitor with IC50 of ~3 μM. |
| CSN10693 | (2R,3R,5S)-2-(6-Amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3-ol | 73-03-0 | Cordycepin is a nucleoside adenosine derivative that acts as an anticancer and antifungal agent. Cordycepin inhibits growth of various tumor cells in vitro. It can be converted to 3'-deoxyadenosine triphosphate (3'-dATP), which inhibits ATP-dependent DNA synthesis. Cordycepin is also useful for the study of messenger RNA transcription. |
| CSN18928 | COH29 | 1190932-38-7 | COH29 is a potent ribonucleotide reductase (RNR) inhibitor with anticancer activity with IC50 value of 8 μM in KB cell. |
| CSN16701 | Clofarabine | 123318-82-1 | Clofarabine inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase. |
| CSN10636 | (S)-(((1-(4-Amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxypropan-2-yl)oxy)methyl)phosphonic acid | 113852-37-2 | Cidofovir is an anti-CMV drug which can suppress CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription. |
| CSN12631 | 4-(4-(Bis(2-chloroethyl)amino)phenyl)butanoic acid | 305-03-3 | Chlorambucil is mainly used in the treatment of chronic lymphocytic leukemia. |
| CSN10592 | Cefuroxime | 55268-75-2 | Cefuroxime is a second-generation variety of cephalosporins with less susceptibility to beta-lactamase. |
| CSN10587 | Ceftiofur HCl | 103980-44-5 | Ceftiofur HCl is a cephalosporin antibiotic used to treat both Gram-positive and Gram-negative bacteria infection. |
| CSN16176 | Pentyl (1-((2R,3R,4S,5R)-3,4-dihydroxy-5-methyltetrahydrofuran-2-yl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate | 154361-50-9 | Capecitabine is a tumor-selective fluoropyrimidine carbamate, which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU, and used as an anti-cancer prodrug. |
| CSN12816 | 5-Bromo-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione | 59-14-3 | Bromodeoxyuridine is a thymidine analogue which is incorporated into DNA. |
| CSN18216 | BRD7116 | 329059-55-4 | BRD7116 competitively binds to bacterial DNA gyrase, exhibits an EC50 of 200 nM for LSCe cells, with cell-non-autonomous anti-leukemia activity. |
| CSN16976 | BMH-21 | 896705-16-1 | BMH-21 is a DNA intercalator that binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription and does not cause phosphorylation of H2AX. |
| CSN16813 | Beaucage Reagent | 66304-01-6 | Beaucage Reagent is potent in causing DNA cleavage. |
| CSN18126 | Galidesivir HCl | 222631-44-9 | BCX 4430 HCl is a viral RNA-dependent RNA polymerase (RdRp) inhibitor and demonstrats broad-spectrum activity in multiple viruses and a favorable preliminary preclinical safety profile. |
| CSN16282 | Galidesivir | 249503-25-1 | BCX 4430 free base is a viral RNA-dependent RNA polymerase (RdRp) inhibitor and demonstrates broad-spectrum activity in multiple viruses and a favorable preliminary preclinical safety profile. |
| CSN18231 | Pritelivir | 348086-71-5 | BAY 57-1293 represents a potent inhibitor of herpes simplex virus (HSV) that target the virus helicase primase complex. |
| CSN18759 | Cyclocytidine Hydrochloride | 10212-25-6 | Ancitabine HCl is the prodrug of cytarabine, which is a pyrimidine nucleoside analog that inhibits the DNA synthesis and used mainly in the treatment of leukemia. |
| CSN18919 | Acelarin | 840506-29-8 | Acelarin is a ProTide transformation and enhancement of the widely-used nucleoside analogue, gemcitabine. |
| CSN12561 | 8-Hydroxyquinoline | 148-24-3 | 8-Hydroxyquinoline inhibits RNA synthesis and acts as a fungicide against Trichophyton mentagrophytes, Myrothecium verrucaria and Trichoderma viride, it's also a monoprotic bidentate chelating agent and dye. |
| CSN64557 | 9-(((E)-4-((2S,3R,4R,5S)-3,4-Dihydroxy-5-(((2S,3S)-3-((2S,3S)-3-hydroxybutan-2-yl)oxiran-2-yl)methyl)tetrahydro-2H-pyran-2-yl)-3-methylbut-2-enoyl)oxy)nonanoic acid | 12650-69-0 |
