|(2R,3R,3aS,9aR)-2-(羟甲基)-6-亚氨基-3,3a,6,9a-四氢-2H-呋喃[2',3':4,5]恶唑并[3,2-a]嘧啶-3-醇盐酸盐|CsnPharm

CAS No.: 10212-25-6

Cyclocytidine Hydrochloride/盐酸环胞苷 Catalog No. CSN18759

Synonyms: Cyclocytidine hydrochloride;Cyclo-CMP hydrochloride;Cyclo-C

Ancitabine HCl is the prodrug of cytarabine, which is a pyrimidine nucleoside analog that inhibits the DNA synthesis and used mainly in the treatment of leukemia.

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描述Ancitabine HCl is an important antileukemia drug, and is the prodrug of cytarabine, which is a pyrimidine nucleoside analog that inhibits the DNA synthesis and used mainly in the treatment of leukemia.
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02197143	Dyspepsia	Phase 4	Completed	-	Turkey ... more >> Pamukkale Universty Denizli, Turkey, 20000 Collapse <<
NCT02125604	Relapsing-Remitting Multiple S... more >>clerosis Collapse <<	Phase 4	Completed	-	Germany ... more >> Research Site Augsburg, Germany Research Site Bamburg, Germany Research Site Bayreuth, Germany Research Site Berlin, Germany Research Site Bochum, Germany Research Site Bonn, Germany Research Site Erbach, Germany Research Site Erlangen, Germany Research Site Freiburg, Germany Research Site Hamburg, Germany Research Site Leipzig, Germany Research Site Marburg, Germany Research Site Minden, Germany Research Site Mittweida, Germany Research Site Munchen, Germany Research Site Munster, Germany Research Site Osnabruck, Germany Research Site Potsdam, Germany Research Site Siegen, Germany Collapse <<
NCT03635372	Dyspepsia	Phase 4	Completed	-	Turkey ... more >> Pamukkale University Denizli, Turkey, 20070 Collapse <<

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参考文献

[1] Kirsch LE, Notari RE. Aqueous conversion kinetics and mechanisms of ancitabine, a prodrug of the antileukemic agent cytarabine. J Pharm Sci. 1984 Jul;73(7):896-902.
[2] Gray GD, Nichol FR, et al. Immunosuppressive, antiviral and antitumor activities of cytarabine derivatives. Biochem Pharmacol. 1972 Feb 15;21(4):465-75.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.8217 mL
- 19.1086 mL
- 38.2172 mL
- 5 mM
- 0.7643 mL
- 3.8217 mL
- 7.6434 mL
- 10 mM
- 0.3822 mL
- 1.9109 mL
- 3.8217 mL

技术信息

CAS号

10212-25-6

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C9H12ClN3O4

运输

蓝冰

分子量

261.66

别名

Cyclocytidine hydrochloride;Cyclo-CMP hydrochloride;Cyclo-C;NSC 145668 HCl;Cyclocytidine HCl;Cyclo-CMP HCl;Cyclocytidine (hydrochloride);2,2′-O-Cyclocytidine hydrochloride;Ancitabine HCl ;NSC-145668;盐酸环胞苷;安西他滨盐酸盐;盐酸安西他滨

溶解度

DMSO	10.0 mg/mL (38.2 mM)
Water	50.0 mg/mL (191.1 mM) warming
Ethanol	Insoluble

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02197143	Dyspepsia	Phase 4	Completed	-	Turkey ... more >> Pamukkale Universty Denizli, Turkey, 20000 Collapse <<
NCT02125604	Relapsing-Remitting Multiple S... more >>clerosis Collapse <<	Phase 4	Completed	-	Germany ... more >> Research Site Augsburg, Germany Research Site Bamburg, Germany Research Site Bayreuth, Germany Research Site Berlin, Germany Research Site Bochum, Germany Research Site Bonn, Germany Research Site Erbach, Germany Research Site Erlangen, Germany Research Site Freiburg, Germany Research Site Hamburg, Germany Research Site Leipzig, Germany Research Site Marburg, Germany Research Site Minden, Germany Research Site Mittweida, Germany Research Site Munchen, Germany Research Site Munster, Germany Research Site Osnabruck, Germany Research Site Potsdam, Germany Research Site Siegen, Germany Collapse <<
NCT03635372	Dyspepsia	Phase 4	Completed	-	Turkey ... more >> Pamukkale University Denizli, Turkey, 20070 Collapse <<
NCT02955134	Chronic Atrophic Gastritis	Not Applicable	Not yet recruiting	May 2020	China ... more >> Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University Not yet recruiting Beijing, China Contact: Shengsheng Zhang, Ph.D 13801088329 Wangjing Hospital of China Academy of Chinese Medical Sciences Not yet recruiting Beijing, China Contact: Wei Wei, Ph.D 13601233816 Xiyuan Hospital of China Academy of Chinese Medical Sciences Not yet recruiting Beijing, China Contact: Xudong Tang, Ph.D 13901137632 Guangdong Provincial TCM Hospital Not yet recruiting Guangzhou, China Contact: Beiping Zhang, Ph.D 13602762766 The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine Not yet recruiting Guangzhou, China Contact: Fengbin Liu, Ph.D 13694239909 GanSu Provincial Hospital of Traditional Chinese Medicine Not yet recruiting Lanzhou, China Contact: Jin Shu, Ph.D 13919276171 Yueyang Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Affiliated Hospital of Shanghai University of Traditional Chinese Medicine Not yet recruiting Shanghai, China Contact: Xiaosu Wang, Ph.D 18930565281 Liaoning Hospital of TCM Not yet recruiting Shenyang, China Contact: Chuijie Wang, Ph.D 13840335840 Hebei Hospital of TCM Not yet recruiting Shijiazhuang, China Contact: Qian Yang, Ph.D 13832355120 Shanxi province hospital of traditional Chinese medicine Not yet recruiting Taiyuan, China Contact: Juanping Su, Ph.D 13935112861 Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital Not yet recruiting Tianjin, China Contact: Huayi Liu, Ph.D 15900369830 Tianjin Nankai Hospital Not yet recruiting Tianjin, China Contact: Yanping Tang, Ph.D 13920925000 Shanxi Traditional Chinese Medicine Hospital Not yet recruiting Xi'an, China Contact: Li Liu, Ph.D 13909102189 Collapse <<
NCT02125604	-	-	Completed	-	-
NCT01928888	Heartburn	Phase 4	Completed	-	Germany ... more >> Frankfurt, Hessen, Germany, 60596 Dresden, Sachsen, Germany, 01307 Leipzig, Sachsen, Germany, 04107 ask Central Contact, Germany Berlin, Germany, 10437 Collapse <<

Cyclocytidine Hydrochloride/盐酸环胞苷 Catalog No. CSN18759

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