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CAS No.: 873857-62-6
Synonyms: OPT-80;PAR-101;Clostomicin-B1
Fidaxomicin is a macrocyclic antibiotic drug that inhibits RNA polymerase sigma subunit, and shows selective eradication of pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that make up the normal, healthy intestinal flora.
生物活性
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT01241552 | Clostridium Difficile Infectio... more >>n Collapse << | Phase 3 | Completed | - | - |
NCT02437591 | Inflammatory Bowel Disease (IB... more >>D) Clostridium Difficile Infection (CDI) Collapse << | Phase 4 | Completed | - | Austria ... more >> Site AT43001 Graz, Austria, 8036 France Site FR33002 Clichy, France, 92110 Site FR33001 Paris, France, 75012 Greece Site GR30004 Athens, Greece, 11527 Italy Site IT39003 Padova, Italy, 35128 Site IT39001 Roma, Italy Poland Site PL48003 Warsaw, Poland, 02-781 Site PL48002 Warszawa, Poland, 02-507 Russian Federation Site RU70003 Moscow, Russian Federation, 119435 Site RU70002 Moscow, Russian Federation, 129110 Site RU70001 Saint Petersburg, Russian Federation, 196247 United Kingdom Site GB44002 London, United Kingdom, E11 1NR Collapse << |
NCT01513239 | Clostridium Difficile Infectio... more >>n Collapse << | Phase 3 | Completed | - | - |
实验方案
技术信息
CAS号 | 873857-62-6 | 储存条件 |
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分子式 | C52H74Cl2O18 | 运输 | 蓝冰 | |||||||
分子量 | 1058.04 | 别名 | OPT-80;PAR-101;Clostomicin-B1;Fidaxomycin;Difimicin;Lipiarmycin;Tiacumicin B;Dificid;Dificlir;非达霉素 | |||||||
溶解度 |
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动物实验配方 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT01241552 | Clostridium Difficile Infectio... more >>n Collapse << | Phase 3 | Completed | - | - |
NCT02437591 | Inflammatory Bowel Disease (IB... more >>D) Clostridium Difficile Infection (CDI) Collapse << | Phase 4 | Completed | - | Austria ... more >> Site AT43001 Graz, Austria, 8036 France Site FR33002 Clichy, France, 92110 Site FR33001 Paris, France, 75012 Greece Site GR30004 Athens, Greece, 11527 Italy Site IT39003 Padova, Italy, 35128 Site IT39001 Roma, Italy Poland Site PL48003 Warsaw, Poland, 02-781 Site PL48002 Warszawa, Poland, 02-507 Russian Federation Site RU70003 Moscow, Russian Federation, 119435 Site RU70002 Moscow, Russian Federation, 129110 Site RU70001 Saint Petersburg, Russian Federation, 196247 United Kingdom Site GB44002 London, United Kingdom, E11 1NR Collapse << |
NCT01513239 | Clostridium Difficile Infectio... more >>n Collapse << | Phase 3 | Completed | - | - |
NCT01241552 | - | - | Completed | - | - |
NCT02570477 | Clostridium Difficile Infectio... more >>n Collapse << | Not Applicable | Active, not recruiting | December 2018 | Hong Kong ... more >> Prince of Wales Hospital Hong Kong, Hong Kong Collapse << |
NCT02403622 | Clostridium Difficile | Phase 2 | Terminated(for futility) | - | United States, Illinois ... more >> Edward Hospital Naperville, Illinois, United States, 60540 United States, Indiana IU University Hospital Indianapolis, Indiana, United States, 46202 United States, Massachusetts Tufts Medical Center Boston, Massachusetts, United States, 02108 United States, New York Montefiore Medical Center Bronx, New York, United States, 10467 Mount Sinai Hospital New York, New York, United States, 10029 United States, Rhode Island Brown University Providence, Rhode Island, United States, 02904 United States, Utah University of Utah Salt Lake City, Utah, United States, 84132 United States, Virginia University of Virginia Charlottesville, Virginia, United States, 22908 Collapse << |
NCT02343328 | Clostridium Difficile | Phase 1 | Terminated(Not enough interest... more >>) Collapse << | - | United States, Massachusetts ... more >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Collapse << |
NCT02573571 | - | - | Completed | - | Greece ... more >> 5th Department of Internal Medicine, Evangelismos Athens General Hospital Athens, Greece, 10676 1st Department of Internal Medicine, "G.Gennimatas" General hospital Athens, Greece, 11527 1st Department of Internal Medicine, Laikon General Hospital Athens, Greece, 11527 3rd Department of Internal Medicine, Sotiria General Hospital Athens, Greece, 11527 4th Department of Internal Medicine, ATTIKON University Hospital Athens, Greece, 12462 2nd Department of Internal Medicine, Sismanogleion General Hospital Athens, Greece, 15126 1st Department of Internal Medicine, Thriassio General Hospital Magoula, Greece, 10918 2nd Department of Internal Medicine, Thriasio General Hospital Magoula, Greece, 10918 2nd Department of Oncology, Mitera Hospital Maroúsi, Greece, 15123 Infections Unit Tzaneion General Hospital Piraeus, Greece Department of Internal Medicine, Patras University Hospital Pátra, Greece, 36504 1st Department of Internal Medicine, AHEPA University Hospital Thessaloniki, Greece, 54248 Collapse << |
NCT02743234 | Clostridium Difficile Infectio... more >>n Collapse << | Phase 3 | Active, not recruiting | April 2019 | Denmark ... more >> Aarhus University Hospital Aarhus C, Denmark, 8000 Collapse << |
NCT01513239 | - | - | Completed | - | - |
NCT03053505 | Clostridium Difficile Infectio... more >>n Collapse << | Not Applicable | Recruiting | October 2018 | Hungary ... more >> Miskolci Semmelweis Korhaz es Egyetemi Oktatokorhaz Recruiting Miskolc, B-A-Z County, Hungary, 3525 Contact: Tibor Pap, M.D. University of Debrecen, Clinical Centre Recruiting Debrecen, Hajdu-Bihar megye, Hungary, 4032 Contact: Gyorgy Paragh, M.D., D.Sc. Szabolcs-Szatmar-Bereg Megyei Korhazak es Egyetemi Oktatokorhaz Recruiting Nyiregyhaza, Szabocs-Szatmar-Bereg megye, Hungary, 4400 Contact: Laszlo Szegedi, M.D. Collapse << |
NCT02667418 | Clostridium D... more >>ifficile Fidaxomicin Vancomycin Collapse << | Phase 4 | Recruiting | May 31, 2022 | - |
NCT00468728 | Clostridium Infections ... more >> Diarrhea Collapse << | Phase 3 | Completed | - | - |
NCT02057198 | - | - | Completed | - | United States, North Carolina ... more >> Duke University Medical Center Durham, North Carolina, United States, 27710 Collapse << |
NCT02179658 | Clostridium Difficile | Phase 3 | Completed | - | Japan ... more >> Chubu, Japan Chugoku, Japan Hokkaido, Japan Kanto, Japan Kinnki, Japan Kyushu, Japan Touhoku, Japan Collapse << |
NCT01775397 | Clostridium Difficile | Phase 4 | Terminated(Study terminated du... more >>e to difficulty in enrollment) Collapse << | - | Austria ... more >> Univ. Klinik für Innere Medizi Salzburg, Austria, 5020 Denmark Herlev University Hospital Herlev, Denmark, 2730 France Institut Curie Paris, France, 75005 Hôpital Necker Paris, France, 75743 Germany Charité Berlin, Germany, 10117 Universitätsklinikum Essen, Germany, 45417 Universitätsklinikum Halle Halle, Germany, 6097 Klinik I für Innere Medizin Koln, Germany, 50937 Greece General Hospital of Athens Athens, Greece, 10675 Laiko General Hospital Athens, Greece, 11527 University Hospital of Crete Heraklion, Greece, 70013 Metaxa Anticancer Hospital Piraeus, Greece, 18537 Poland Szpital Specjalistyczny w Brzo Brzozów, Poland, 36-200 Spain H. U. de Bellvitge Barcelona, Spain, 08907 H.U. Gregorio Maranon Madrid, Spain, 28007 Hospital 12 de Octubre Madrid, Spain, 28041 Collapse << |
NCT00314951 | Clostridium Infections ... more >> Diarrhea Collapse << | Phase 3 | Completed | - | - |
NCT00468728 | - | - | Completed | - | - |
NCT02355938 | Clostridium Difficile ... more >> Spinal Cord Injury Collapse << | Phase 4 | Terminated(Lost funding due to... more >> low enrollment.) Collapse << | - | United States, Texas ... more >> Michael E. DeBakey VA Medical Center Houston, Texas, United States, 77030 Collapse << |
NCT02784002 | Clostridium Difficile Infectio... more >>n Collapse << | Phase 2 | Completed | - | United States, California ... more >> Laguna Hills Laguna Hills, California, United States, 92653 Ventura Ventura, California, United States, 93003 United States, Idaho Idaho Idaho Falls, Idaho, United States, 83404 United States, Montana Butte Butte, Montana, United States, 59701 United States, New Jersey New Jersey Somers Point, New Jersey, United States, 08244 Czechia Liberec Liberec, Czechia Pardubice Pardubice, Czechia Praha Praha, Czechia Zlin Zlin, Czechia United Kingdom Leeds Leeds, United Kingdom Liverpool Liverpool, United Kingdom London London, United Kingdom Manchester Manchester, United Kingdom Newcastle Upon Tyne Newcastle Upon Tyne, United Kingdom Oxford Oxford, United Kingdom Wigan Wigan, United Kingdom Collapse << |
NCT02254967 | Clostridium Difficile | Phase 4 | Completed | - | - |
NCT02464306 | Clostridium Difficile Infectio... more >>n Solid Organ Transplant Collapse << | Phase 4 | Withdrawn(Lost funding) | June 2019 | - |
NCT01533844 | - | - | Terminated(Terminated due to t... more >>he fact that the required number of trial subjects was not met.) Collapse << | - | France ... more >> Site: 3301 Poissy, Paris, France, 92141 Site: 3302 Lyon, France, 69677 Germany Site: 4902 Erlangen, Germany, 91054 Site: 4904 Hanover, Germany, 30625 Site: 4901 Munich, Germany, 80337 Netherlands Site: 3102 Maastricht, Netherlands, 6229HX Spain Site: 3403 Granada, Spain, 18014 Site: 3402 Madrid, Spain, 28046 Site: 3401 Valencia, Spain, 46026 Collapse << |
NCT00314951 | - | - | Completed | - | - |
NCT01818141 | Clostridium Difficile Infectio... more >>n Collapse << | Phase 4 | Completed | - | United States, Connecticut ... more >> Hartford Hospital Hartford, Connecticut, United States, 06102 Collapse << |
NCT01691248 | - | - | Completed | - | - |
NCT01591863 | Clostridium Difficile-associat... more >>ed Diarrhea Collapse << | Phase 2 | Completed | - | - |
NCT01818141 | - | - | Completed | - | - |
NCT01691248 | Clostridium Difficile-Associat... more >>ed Diarrhea (CDAD) Collapse << | Phase 3 | Completed | - | - |
NCT02461901 | - | - | Active, not recruiting | December 2017 | United Kingdom ... more >> St George's University Hospitals NHS Foundation Trust Tooting, London, United Kingdom, SW19 0QT Bradford Teaching Hospitals NHS Foundation Trust Bradford, West Yorkshire, United Kingdom, BD9 6RJ Leeds Teaching Hospitals NHS Trust Leeds, West Yorkshire, United Kingdom, LS1 3EX Collapse << |
NCT01591863 | - | - | Completed | - | - |
NCT02218372 | Clostridium Difficile-associat... more >>ed Diarrhea (CDAD) Collapse << | Phase 3 | Completed | - | - |
NCT02692651 | Clostridium Difficile Infectio... more >>n (CDI) Collapse << | Phase 4 | Recruiting | April 2020 | United States, Michigan ... more >> University of Michigan Recruiting Ann Arbor, Michigan, United States, 48091 Contact: Keith S Kaye, MD 734-615-1901 keithka@med.umich.edu Contact: Jolene Daniel 734-615-1901 jolened@med.umich.edu Collapse << |
NCT02218372 | - | - | Completed | - | - |
NCT01552668 | Clostridium Difficile Infectio... more >>n Collapse << | Phase 4 | Withdrawn(Study not performed) | - | United States, Missouri ... more >> Washington University in St. Louis St. Louis, Missouri, United States, 63110 Collapse << |
NCT02214771 | - | - | Completed | - | France ... more >> Site Bethune, France Site Bordeaux, France Site Boulogne Billancourt, France Site Caen Cedex 9, France Site Chambéry, France Site Clermond-Ferrand, France Site Clichy, France Site Dijon, France Site Garches, France Site La Tronche, France Site Lille, France Site Lyon, France Site Marseille, France Site Morlaix, France Site Mulhouse, France Site Nantes, France Site Nimes, France Site Orléans Cedex 2, France Site Paris, France Site Poitiers, France Site Reims, France Site Rennes Cedex, France Site Roubaix Cedex 1, France Site Soissons, France Collapse << |
NCT02395848 | Clostridium Difficile Infectio... more >>n Collapse << | Phase 3 | Active, not recruiting | June 2018 | Canada, British Columbia ... more >> Island Health Victoria, British Columbia, Canada, V8R 1J8 Collapse << |
NCT01813448 | Pharmacokinetics of Fidaxomici... more >>n Healthy Subjects Collapse << | Phase 1 | Completed | - | United States, California ... more >> Parexel Glendale, California, United States, 91206 Collapse << |
NCT03760484 | Clostridium Difficile | Phase 2 | Not yet recruiting | March 16, 2022 | - |
NCT02083627 | Drug-Drug Interaction (DDI) ... more >> Intestinal Absorption Healthy Subjects Pharmacokinetics of Rosuvastatin Pharmacokinetics of Fidaxomicin Collapse << | Phase 1 | Completed | - | Germany ... more >> Parexel GmbH Berlin, Germany, D-14059 Collapse << |
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