|5-溴-1-((2R,4S,5R)-4-羟基-5-(羟甲基)四氢呋喃-2-基)嘧啶-2,4(1H,3H)-二酮|CsnPharm

CAS No.: 59-14-3

5-溴-2'-脱氧尿苷 Catalog No. CSN12816

Synonyms: BrdU;5-Bromo-2'-deoxyuridine;BUdR

Bromodeoxyuridine is a thymidine analogue which is incorporated into DNA.

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生物活性

描述Bromodeoxyuridine (BrdUrd), a thymidine analogue incorporated into DNA, can be quantified by fluorescent or chromophoric quenching of dyes bound to DNA or with antibodies to BrdUrd^[3]. Bromodeoxyuridine, even at a level of substitution into newly mad DNA of 95%, has no effect on the 5-methylcytosine content of DNA. At all levels of bromodeoxyuridine substitution, highly repetitive DNA has slightly more 5-methylcytosine (3.0% of total cytosine) than does single copy DNA or moderately repetitive DNA (2.3%)^[4]. A single, brief in vitro exposure to BrdU induces a profound and sustained reduction in the proliferation rate of all cancer cells examined. Cells do not die but variably up-regulate some senescence-associated proteins as they accumulate in the G1 phase of the cell cycle. Bromodeoxyuridine also impairs the proliferative capacity of primary tumor-initiating human glioma cells and may therefore represent a means of targeting cancer stem cells^[5]. Bromodeoxyuridine (BrdU) is widely used in immunology to detect cell division, and several mathematical models have been proposed to estimate proliferation and death rates of lymphocytes from BrdU labelling and de-labelling curves^[6]. The BrdU-dependency of arrest in the G2 phase can be used as a sensitive cell biological assay to detect DNA damage elicited by oxygen free radicals^[7].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03371134	-	-	Not yet recruiting	July 26, 2020	-
NCT00003405	Leukemia	Phase 2	Unknown	-	United States, Illinois ... more >> Cook County Hospital Chicago, Illinois, United States, 60612-9985 Rush Cancer Institute Chicago, Illinois, United States, 60612 Angelo P. Creticos, M.D. Cancer Center Chicago, Illinois, United States, 60657 Rush-Riverside Cancer Center Kankakee, Illinois, United States, 60901 Collapse <<
NCT02576145	-	-	Completed	-	-

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.2563 mL
- 16.2814 mL
- 32.5629 mL
- 5 mM
- 0.6513 mL
- 3.2563 mL
- 6.5126 mL
- 10 mM
- 0.3256 mL
- 1.6281 mL
- 3.2563 mL

技术信息

CAS号

59-14-3

储存条件

粉末: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C9H11BrN2O5

运输

蓝冰

分子量

307.10

别名

BrdU;5-Bromo-2'-deoxyuridine;BUdR;Bromodeoxyuridine;Broxuridine;NSC 38297;5-溴脱氧尿嘧啶核苷

溶解度

DMSO	59.0 mg/mL (192.1 mM)
Water	Insoluble
Ethanol	2.0 mg/mL (6.5 mM) warming

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT03371134	-	-	Not yet recruiting	July 26, 2020	-
NCT00003405	Leukemia	Phase 2	Unknown	-	United States, Illinois ... more >> Cook County Hospital Chicago, Illinois, United States, 60612-9985 Rush Cancer Institute Chicago, Illinois, United States, 60612 Angelo P. Creticos, M.D. Cancer Center Chicago, Illinois, United States, 60657 Rush-Riverside Cancer Center Kankakee, Illinois, United States, 60901 Collapse <<
NCT02576145	-	-	Completed	-	-
NCT01320137	Immunologic Tests	Not Applicable	Completed	-	Belgium ... more >> GSK Investigational Site Gent, Belgium, 9000 GSK Investigational Site La Louvière, Belgium, 7100 Collapse <<
NCT01320137	-	-	Completed	-	-
NCT00042250	Hematologic Malignancies	Not Applicable	Completed	-	United States, Texas ... more >> M.D. Anderson Cancer Center Houston, Texas, United States, 77030 Collapse <<
NCT02576145	Kidney Transplantation	Phase 4	Completed	-	United States, California ... more >> Los Angeles, California, United States, 90027-6062 Los Angeles, California, United States, 90095-1752 United States, Indiana Indianapolis, Indiana, United States, 46202 United States, Missouri Kansas City, Missouri, United States, 64108 United States, Oregon Portland, Oregon, United States, 97201 Collapse <<
NCT00001650	-	-	Completed	-	United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse <<
NCT00003832	Stage I Prostate Cancer ... more >> Stage IIA Prostate Cancer Stage IIB Prostate Cancer Collapse <<	Phase 2	Completed	-	United States, Colorado ... more >> University of Colorado Denver, Colorado, United States, 80217-3364 Collapse <<
NCT02654925	-	-	Recruiting	December 2020	United States, Colorado ... more >> University of Colorado Anschutz Medical Campus Recruiting Aurora, Colorado, United States, 80045 Contact: Kathleen M Gavin, PhD 303-724-7472 kathleen.gavin@ucdenver.edu Collapse <<

5-溴-2'-脱氧尿苷 Catalog No. CSN12816

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