CAS No.: 136164-66-4
E3330 Catalog No. CSN18804
Synonyms: APX-3330
E3330 is a potent and selective APE1 (Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.
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生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT03375086 Cancer Phase 1 Recruiting June 1, 2019 United States, Indiana ... more >> Indiana University Simon Cancer Center Recruiting Indianapolis, Indiana, United States, 46202 Contact: Lauren Bracey 317-274-3502 lbracey@iu.edu United States, Michigan START Midwest Recruiting Grand Rapids, Michigan, United States, 49546 Contact: Kathy Estkowski, BS, CCRP 616-954-5551 kathy.estkowski@startmidwest.com Contact: Yvette C Cole, RN, BSN, OCN 616-389-1652 yvette.cole@startmidwest.com United States, Texas START San Antonio Recruiting San Antonio, Texas, United States, 78229 Contact: Isabel Jimenez, RN, MSN 210-593-5265 isabel.jimenez@start.stoh.com Collapse << - 参考文献
- [1] Zou GM, Maitra A. Small-molecule inhibitor of the AP endonuclease 1/REF-1 E3330 inhibits pancreatic cancer cell growth and migration. Mol Cancer Ther. 2008 Jul;7(7):2012-21.
- [2] Zou GM, Luo MH, et al. Ape1 regulates hematopoietic differentiation of embryonic stem cells through its redox functional domain. Blood. 2007 Mar 1;109(5):1917-22.
实验方案
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技术信息
| CAS号 | 136164-66-4 | 储存条件 |
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| 分子式 | C21H30O6 | 运输 | 蓝冰 | |
| 分子量 | 378.46 | 别名 | APX-3330 |
