|8-羟基喹啉|CsnPharm

CAS No.: 148-24-3

8-羟基喹啉 Catalog No. CSN12561

Synonyms: 8-羟基喹啉;8-Quinolinol

8-Hydroxyquinoline inhibits RNA synthesis and acts as a fungicide against Trichophyton mentagrophytes, Myrothecium verrucaria and Trichoderma viride, it's also a monoprotic bidentate chelating agent and dye.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述8-Hydroxyquinoline is a monoprotic bidentate chelating agent, exhibits antiseptic, disinfectant, and pesticide properties, functioning as a transcription inhibitor. The 8-hydroxyquinoline pharmacophore scaffold has been shown to possess a range of activities as metal chelation, enzyme inhibition, cytotoxicity, and cytoprotection^[3]. The cytotoxicity of 8-hydroxyquinoline oxovanadium(v) complexes is higher in the A2780 cell line (lower IC50) than that observed for the widely used chemotherapeutic agent, cisplatin, while displaying low cytotoxicity for normal human primary fibroblasts. Substituents introduced into the 8-hydroxyquinoline backbone reduced the antiproliferative effect of the vanadium complexes, and the complexes with the ligand substituted only in the 5 position (5 and 6) were more cytotoxic than those with substituents in the 5,7 positions of the quin backbone (1-4)^[4].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03034291	Insulin Resistance	Not Applicable	Completed	-	-
NCT00243594	Melanoma Stage III or IV	Phase 1 Phase 2	Completed	-	Netherlands ... more >> Radboud University Nijmegen Medical Centre Nijmegen, PO Box 9101, Netherlands, 6500 HB Collapse <<
NCT01429012	Nonunion Fracture	Phase 2	Unknown	November 2017	Belgium ... more >> Liège University Hospital Not yet recruiting Liège, Belgium, 4000 Contact: Yves Beguin, Prof; MD; PhD 32/4/3667201 yves.beguin@chu.ulg.ac.be Contact: Jean-Philippe Hauzer, MD; PhD 32/4/3667863 jean-philippe.hauzeur@chu.ulg.ac.be Sub-Investigator: Chantal Lechanteur, PhD Sub-Investigator: Etienne Baudoux, MD Sub-Investigator: Michel Malaise, Prof, MD, PhD Sub-Investigator: William Kurth, MD Sub-Investigator: Henri Van Cauwenberge, MD Sub-Investigator: Philippe Gillet, Prof, MD, PhD Sub-Investigator: Roland Hustinx, Prof, MD, PhD Sub-Investigator: Claire Bernard Sub-Investigator: Paolo Simoni, MD Collapse <<

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参考文献

[1] Fraser RS, Creanor J. Rapid and selective inhibition of RNA synthesis in yeast by 8-hydroxyquinoline. Eur J Biochem. 1974 Jul 1;46(1):67-73.
[2] Suzuki H, Ogura Y. Mode of inhibition of the Aspergillus amine oxidase by 8-hydroxyquinoline. J Biochem. 1972 Oct;72(4):833-9.
[3] Kanizsai I, Madácsi R, Hackler L Jr, Gyuris M, Szebeni GJ, Huzián O, Puskás LG. Synthesis and Cytoprotective Characterization of 8-Hydroxyquinoline Betti Products. Molecules. 2018 Aug 2;23(8):1934
[4] Choroba K, Raposo LR, Palion-Gazda J, Malicka E, Erfurt K, Machura B, Fernandes AR. In vitro antiproliferative effect of vanadium complexes bearing 8-hydroxyquinoline-based ligands - the substituent effect. Dalton Trans. 2020 May 26;49(20):6596-6606

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 6.8890 mL
- 34.4448 mL
- 68.8895 mL
- 5 mM
- 1.3778 mL
- 6.8890 mL
- 13.7779 mL
- 10 mM
- 0.6889 mL
- 3.4445 mL
- 6.8890 mL

技术信息

CAS号

148-24-3

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C9H7NO

运输

蓝冰

分子量

145.16

别名

8-羟基喹啉;8-Quinolinol

溶解度

DMSO	50.0 mg/mL (344.4 mM) warming

动物实验配方

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8-羟基喹啉 Catalog No. CSN12561

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