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CAS No.: 112887-68-0
Synonyms: ZD1694;D1694;ICI-D1694
Raltitrexed is an inhibitor of thymidylate synthase with IC50 of 9 nM in L1210 cell.
生物活性
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT02678806 | HepatoCellular Carcinoma | Not Applicable | Recruiting | November 1, 2022 | China, Guangxi ... more >> TaoBai Recruiting Nanning, Guangxi, China, 530000 Contact: Bai Tao, MD +86 13878862632 25859373@qq.com Collapse << |
NCT01703910 | Adenocarcinoma of Colon ... more >> Adenocarcinoma of Rectum Metastatic Disease Collapse << | Phase 2 | Completed | - | Spain ... more >> Hospital Universitario de Fuenlabrada Fuenlabrada, Madrid, Spain, 28950 Hospital Madrid Norte Sanchinarro Madrid, Spain, 28050 Collapse << |
NCT01481545 | Rectal Cancer | Phase 2 | Unknown | July 2018 | - |
实验方案
技术信息
CAS号 | 112887-68-0 | 储存条件 |
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分子式 | C21H22N4O6S | 运输 | 蓝冰 | |||||||||||||
分子量 | 458.49 | 别名 | ZD1694;D1694;ICI-D1694;TDX;brand name: Tomudex;雷替曲塞 | |||||||||||||
溶解度 |
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动物实验配方 |
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Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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chinese hamster D4 cells | - | Proliferation assay | 96 h | Antiproliferative activity against chinese hamster D4 cells expressing human FRbeta assessed as reduction of viable cells after 96 hrs, IC50=22 nM | 21879757 |
human HepG2 cells | - | Cytotoxicity assay | 48 h | Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50=1.3 μM | 23490159 |
human IGROV1 cells | - | Proliferation assay | - | Antiproliferative activity against human RFC and FRalpha expressing human IGROV1 cells, IC50=12.6 nM | 18680275 |
human KB cells | - | Cytotoxicity assay | 96 h | Cytotoxicity against human KB cells assessed as cell growth inhibition incubated up to 96 hrs by Celltiter-blue cell viability assay, IC50=5.9 nM | 25234128 |
human KB cells | 200 nM | Cytotoxicity assay | 96 h | Cytotoxicity against human KB cells assessed as cell growth inhibition incubated up to 96 hrs in presence of 200 nM folic acid by Celltiter-blue cell viability assay, IC50=22 nM | 25234128 |
L1210 cell line | - | Growth inhibition assay | - | Growth inhibition of murine tumor L1210 cell line, IC50=9 nM | 10508430 |
L1210 mouse leukemia cells | - | Function assay | - | Compound was evaluated for inhibition of thymidylate synthase, partially purified from L1210 mouse leukemia cells that overproduce thymidylate synthase due to amplification of TS gene, Ki=0.418 μM | 1372358 |
MCF7 cells | - | Cytotoxicity assay | 48 h | Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay, IC50=12.6 μM | 23490159 |
PC43-10 cells | - | Function assay | 96 h | Inhibition of RFC (unknown origin) expressed in Chinese hamster PC43-10 cells assessed as cell growth inhibition incubated up to 96 hrs by Celltiter-blue cell viability assay, IC50=6.3 nM | 25234128 |
R2 cells | - | Cytotoxicity assay | 96 h | Cytotoxicity against chinese hamster R2 cells expressing human PCFT4 after 96 hrs by CellTitre-Blue fluorescence assay | 24256410 |
R2 cells | - | Growth inhibition assay | 96 h | Growth inhibition of Chinese hamster R2 cells expressing human PCFT4 after 96 hrs by CellTiter-blue assay, IC50=0.0995 μM | 24111942 |
R2/PCFT4 cells | - | Function assay | 96 h | Inhibition of PCFT (unknown origin) expressed in Chinese hamster R2/PCFT4 cells assessed as cell growth inhibition incubated up to 96 hrs by Celltiter-blue cell viability assay, IC50=0.0995 μM | 25234128 |
RT16 cells | - | Proliferation assay | 96 h | Antiproliferative activity against chinese hamster RT16 cells expressing human FRalpha assessed as reduction of viable cells after 96 hrs, IC50=15 nM | 21879757 |
SGC7901 cells | - | Cytotoxicity assay | 48 h | Cytotoxicity against human SGC7901 cells after 48 hrs by MTT assay, IC50=8.7 μM | 23490159 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT02678806 | HepatoCellular Carcinoma | Not Applicable | Recruiting | November 1, 2022 | China, Guangxi ... more >> TaoBai Recruiting Nanning, Guangxi, China, 530000 Contact: Bai Tao, MD +86 13878862632 25859373@qq.com Collapse << |
NCT01703910 | Adenocarcinoma of Colon ... more >> Adenocarcinoma of Rectum Metastatic Disease Collapse << | Phase 2 | Completed | - | Spain ... more >> Hospital Universitario de Fuenlabrada Fuenlabrada, Madrid, Spain, 28950 Hospital Madrid Norte Sanchinarro Madrid, Spain, 28050 Collapse << |
NCT01481545 | Rectal Cancer | Phase 2 | Unknown | July 2018 | - |
NCT00797719 | Malignant Pleural Mesothelioma | Phase 1 Phase 2 | Recruiting | July 2019 | Canada, Ontario ... more >> University Health Network Recruiting Toronto, Ontario, Canada, M5G 2M9 Contact: John Cho, MD 416 946 2124 john.cho@rmp.uhn.on.ca Principal Investigator: John Cho, MD Collapse << |
NCT03191487 | Colorectal Neoplasms | Not Applicable | Withdrawn(no Financial agreeme... more >>nt) Collapse << | November 2019 | France ... more >> Institut Sainte Catherine Avignon Cedex 9, France, 84918 Institut de Cancérologie Montpellier Montpellier Cedex 5, France, 34298 CHRU de Nîmes - Hôpital Universitaire Carémeau Nîmes, France, 30029 CHRU de Strasbourg - Hôpital de Hautepierre Strasbourg, France, 67098 CHRU de Toulouse - Hôpital de Rangueil Toulouse Cedex 9, France, 31059 IUCT-Oncopole Toulouse, France, 31100 Collapse << |
NCT01869023 | Advanced Malignant Pleural Mes... more >>othelioma Collapse << | Phase 2 | Active, not recruiting | December 2017 | Mexico ... more >> Instituto Nacional de Cancerología Mexico City, Mexico Collapse << |
NCT03179579 | Gastric Cancer ... more >> Peritoneal Carcinomatosis Collapse << | Phase 3 | Not yet recruiting | August 1, 2022 | China, Guangdong ... more >> Department of Abdominal Surgery (Section 2), Affiliated Tumor Hospital of Guangzhou Medical University Not yet recruiting Guangzhou, Guangdong, China, 510095 Contact: Xianzi Yang, M.D 8602066673666 7097359@qq.com Principal Investigator: shuzhong cui, M.D Collapse << |
NCT02376452 | Colorectal Carcinoma | Phase 2 | Unknown | December 2016 | China, Shanghai ... more >> Fudan University Cancer Hospital Recruiting ShangHai, Shanghai, China Contact: Jin Li, PhD, M.D 862164175590 ext 1108 fudanlijin@163.com Collapse << |
NCT02723253 | Rectal Neoplasms | Phase 2 | Completed | - | - |
NCT00002902 | Unspecified Adult Solid Tumor,... more >> Protocol Specific Collapse << | Phase 1 | Completed | - | United States, Pennsylvania ... more >> University of Pennsylvania Cancer Center Philadelphia, Pennsylvania, United States, 19104 Collapse << |
NCT00004254 | Malignant Mesothelioma | Phase 2 | Completed | - | Italy ... more >> Ospedale Bellaria Bologna, Italy, I-40139 Istituto Nazionale per la Ricerca sul Cancro Genoa, Italy, 16132 Istituto Nazionale per lo Studio e la Cura dei Tumori Naples, Italy, 80131 Universita Degli Studi di Udine Udine, Italy, 33100 Netherlands Antoni van Leeuwenhoekhuis Amsterdam, Netherlands, 1066 CX Vrije Universiteit Medisch Centrum Amsterdam, Netherlands, 1117 MB Collapse << |
NCT00003109 | Unspecified Adult Solid Tumor,... more >> Protocol Specific Collapse << | Phase 1 | Completed | - | United States, Pennsylvania ... more >> Fox Chase Cancer Center Philadelphia, Pennsylvania, United States, 19111 Collapse << |
NCT01532804 | Metastatic Colorectal Cancer | Phase 2 | Active, not recruiting | December 2018 | France ... more >> Val d'Aurelle Cancer Institute Montpellier, France, 34298 Collapse << |
NCT00002828 | Colorectal Cancer | Phase 1 | Completed | - | United States, New York ... more >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 Collapse << |
NCT00001341 | Neoplasm | Phase 1 | Completed | - | United States, Maryland ... more >> National Cancer Institute (NCI) Bethesda, Maryland, United States, 20892 Collapse << |
NCT00004920 | Malignant Mesothelioma | Phase 3 | Completed | - | - |
NCT02965248 | Locally Advanced Colorectal Ca... more >>ncer Collapse << | Phase 3 | Recruiting | November 2023 | China, Shanghai ... more >> Fudan University Shanghai Cancer Center Recruiting Shanghai, Shanghai, China, 200032 Contact: Guoxiang Cai, M.D. Ph.D. +86 13611831623 gxcai@fudan.edu.cn Collapse << |
NCT02453490 | Colorectal Cancer ... more >> Liver Metastasis Collapse << | Phase 3 | Recruiting | September 2018 | China, Guangdong ... more >> The Affiliated Tumor Hospital of Zhongshan University Not yet recruiting Guangzhou, Guangdong, China, 510060 Principal Investigator: Zhi-Zhong Pan, MD/PHD China, Hubei Wuhan Union Hospital Not yet recruiting Wuhan, Hubei, China, 430022 Principal Investigator: Kai-Xiong Tao, MD/PHD Zhongnan Hospital Affiliated to Wuhan University Not yet recruiting Wuhan, Hubei, China, 430071 Principal Investigator: Bing Xiong, MD China, Shanghai Changhai Hospital of Shanghai Recruiting Shanghai, Shanghai, China, 200433 Principal Investigator: Wei Zhang, MD China, Zhejiang The First Affiliated Hospital of College of Medicine Zhejiang University Not yet recruiting Hangzhou, Zhejiang, China, 310003 Principal Investigator: Jianjiang Lin, M.D. Second Affiliated Hospitalof Zhejiang University School of Medicine Recruiting Hangzhou, Zhejiang, China, 310009 Contact: Ke-Feng Ding, PhD/MD 86-571-87784827 dingkefeng@zju.edu.cn Principal Investigator: Ke-Feng Ding, PhD/MD Sir Run Run Shaw Hospital, Zhejiang University School of Medicine Recruiting Hangzhou, Zhejiang, China, 310016 Principal Investigator: Xuefeng Huang, M.D. Jinhua People's Hospital Recruiting Jinhua, Zhejiang, China, 321000 Principal Investigator: Jinlin Du, M.D. The second hospital of Ningbo City Recruiting Ningbo, Zhejiang, China, 315010 Principal Investigator: Xiao-Yu Dai, MD Collapse << |
NCT02631564 | - | - | Unknown | December 2018 | China, Shanghai ... more >> Fudan University Zhongshan Hospital Recruiting Shanghai, Shanghai, China, 200032 Contact: Bo Zhou, M.D,Ph.D 8621-18616880602 Collapse << |
NCT00590278 | Inoperable or Recurrent Rectal... more >> Cancer Collapse << | Phase 2 | Completed | - | Turkey ... more >> Research Site Istanbul, Turkey Collapse << |
NCT00234429 | Colorectal Cancer | Phase 2 Phase 3 | Completed | - | Spain ... more >> Research Site A Coruna, Spain Research Site Barcelona, Spain Research Site Burgos, Spain Research Site Gijon, Spain Research Site Leon, Spain Research Site Madrid, Spain Research Site Oviedo, Spain Research Site Pamplona, Spain Research Site Valladolid, Spain Collapse << |
NCT02821559 | Metastatic Colorectal Cancer | Phase 2 | Completed | - | France ... more >> CHRU de Besançon Besançon, France Collapse << |
NCT00003528 | Recurrent Childhood Acute Lymp... more >>hoblastic Leukemia Recurrent Childhood Acute Myeloid Leukemia Collapse << | Phase 1 | Completed | - | Switzerland ... more >> Swiss Pediatric Oncology Group - Geneva Geneva, Switzerland, 1205 Collapse << |
NCT02485548 | Head and Neck Squamous Cell Ca... more >>ncer Collapse << | Phase 3 | Unknown | June 2018 | China, Jiangsu ... more >> Jiangsu Cancer Hospital Recruiting Nanjing, Jiangsu, China, 210009 Contact: Xuesong Jiang, M.D. 13851700790@126.com Sub-Investigator: Xuesong Jiang, M.D. Collapse << |
NCT01959061 | Colorectal Cancer Metastatic | Phase 4 | Recruiting | December 2017 | China, Shanghai ... more >> Zhongshan Hospital Fudan University Recruiting Shanghai, Shanghai, China, 2000032 Contact: Jianhua Wang Collapse << |
NCT02992886 | Rectal Neoplasms Malignant | Phase 2 | Recruiting | September 2022 | China, Beijing ... more >> Department of Radiation Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Recruiting Beijing, Beijing, China, 100021 Contact: Wenyang Liu, MD liuwenyang26@163.com Collapse << |
NCT01732380 | Inoperable Esophageal Cancer S... more >>tage I-III Collapse << | Phase 2 | Unknown | July 2013 | China, Jiangsu ... more >> The First People`s Hospital of Lianyungang Recruiting Lianyungang, Jiangsu, China, 222002 Contact: Xiaodong Jiang, Doctor jxdysy1970@163.com Collapse << |
NCT03126071 | Advanced Colorectal Cancer | Phase 2 | Recruiting | February 15, 2020 | China, Jiangsu ... more >> Jiangsu Cancer Institute & Hospital Recruiting Nanjing, Jiangsu, China, 210009 Contact: Liangjun Zhu +8613905199123 zhulj98@foxmail.com Contact: Yuejiao Zhong +861370575447 zhongyuejiao@163.com Nantong Tumor Hospital Active, not recruiting Nantong, Jiangsu, China, 226000 The First Affiliated Hospital of Soochow University Recruiting Suzhou, Jiangsu, China, 215000 Contact: Chunrong Zhu, M.D. +8613063870566 zcr050311@163.com Contact: Feng Xiong +8613270971002 greenlemontea@126.com China, Shanghai Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Not yet recruiting Shanghai, Shanghai, China, 200025 Contact: Jun Zhang, M.D. Collapse << |
NCT01836120 | Gastric Cancer | Phase 2 | Unknown | June 2017 | China, Hebei ... more >> Hebei Tumor Hospital Shijiazhuang, Hebei, China, 050011 Collapse << |
NCT02072317 | Advanced Gastric Cancer | Phase 2 | Unknown | March 2016 | China, Shanghai ... more >> Cancer hospital Fudan University Recruiting Shanghai, Shanghai, China, 200032 Contact: GUO WEI JIAN, doctor 13816066360 guoweijian1@hotmail.com Collapse << |
NCT00002893 | Colorectal Cancer | Phase 3 | Unknown | - | United Kingdom ... more >> Velindre Hospital Cardiff, Wales, United Kingdom, CF4 7XL Collapse << |
NCT03585530 | Esophagus Squamous Cell Carcin... more >>oma Collapse << | Phase 2 | Not yet recruiting | July 15, 2022 | - |
NCT03083613 | Gastric Cancer ... more >> Gastroesophageal Junction Adenocarcinoma Collapse << | Phase 2 | Unknown | December 2018 | China ... more >> Chinese Academy of Medical Sciences Recruiting Beijing, China, 10000 Contact: Ai ping Zhou 8610-87788145 zhouap1825@126.com Collapse << |
NCT03053167 | ColoRectal Cancer | Phase 2 | Recruiting | December 2020 | China, Liaoning ... more >> The First Hospital of China Medical University Recruiting Shenyang, Liaoning, China, 110001 Contact: Yunpeng Liu, MD., PhD 86-24-83282312 cmuliuyunpeng@hotmail.com Principal Investigator: Yunpeng Liu, MD., PhD. Collapse << |
NCT03398512 | Peritoneal Metastases From Col... more >>orectal Cancer Collapse << | Not Applicable | Recruiting | December 31, 2020 | China, Hubei ... more >> Wuhan University Recruiting Wuhan, Hubei, China Contact: Bin Xiong +86 27 67813152 jyn1983@163.com Collapse << |
NCT02562599 | Nasopharyngeal Carcinoma | Phase 2 | Unknown | August 2018 | China, Hubei ... more >> Hubei Cancer hospital Recruiting Wu Han, Hubei, China, 430079 Contact: Han Guang, PH.D Principal Investigator: Hu Desheng, M.D Collapse << |
NCT02618356 | Metastatic Colon Cancer | Phase 2 | Recruiting | November 2017 | China, Shanghai ... more >> Fudan University Cancer Hospital Recruiting ShangHai, Shanghai, China, 200032 Contact: Wei Jian Guo 13816066360 mingzhuhuang0718@163.com Collapse << |
NCT03344614 | Colorectal Cancer | Phase 2 | Recruiting | July 1, 2019 | China, Beijing ... more >> Chinese PLA General Hospital (301 Military Hospital) Recruiting Beijing, Beijing, China, 100853 Contact: Haiyan Si, M.D. +8613911070673 sihaiyan2008@sina.com Collapse << |
NCT03196843 | Head and Neck Squamous Cell Ca... more >>rcinoma Collapse << | Phase 4 | Recruiting | August 2022 | China, Liaoning ... more >> Lv Xiupeng Recruiting Dalian, Liaoning, China, 116000 Contact: Xiupeng Lv, M.D. 18098876707 lvxiupeng@foxmail.com Collapse << |
NCT01348412 | Colorectal Cancer ... more >> Liver Metastases Collapse << | Phase 2 | Completed | - | France ... more >> Centre Georges François Leclerc Dijon, France, 21000 Collapse << |
NCT03392103 | Gastric Cancer | Phase 2 | Recruiting | December 2019 | China, Hubei ... more >> Zhongnan Hopital of Wuhan University Recruiting Wuhan, Hubei, China, 430071 Contact: Fuxiang Zhou, M.D. +86(0)2767813155 fuxiang.zhou@whu.edu.cn Contact: Jing Dai, M.D. +86(0)2767813155 daijing1116@163.com Collapse << |
NCT02557490 | Colon Cancer Liver Metastasis | Phase 4 | Unknown | December 2017 | China, Beijing ... more >> Beijing Cancer Hospital Recruiting Beijing, Beijing, China, 100142 Contact: Zhu Xu, Master 0086-10-88195476 zhux387@263.net Principal Investigator: Zhu Xu, Master Collapse << |
靶点 | Description | IC50 |
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