|(2S)-2-((S)-2-(((苄氧基)羰基)氨基)-4-甲基戊酰胺基)-1-羟基-3-(2-氧代吡咯烷-3-基)丙烷-1-磺酸钠盐|CsnPharm

CAS No.: 1416992-39-6

Sodium (2S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-4-methylpentanamido)-1-hydroxy-3-(2-oxopyrrolidin-3-yl)propane-1-sulfonate Catalog No. CSN25342

Synonyms: GC376 sodium

GC376 is a 3CLpro (3C-like protease) inhibitor that shows promise in treating cats with certain presentations of FIP and has opened the door to targeted antiviral drug therapy.

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技术信息

生物活性

描述The coronavirus 3C-like protease (3CL^pro) has a conserved structure and catalytic mechanism and plays a key role during viral polyprotein processing, thus serving as an appealing antiviral drug target. GC376 exerts strong inhibitory effects on the PEDV (porcine epidemic diarrhea virus) 3CL^pro with an IC₅₀ of approximately 1.11 μM. The EC₅₀ values of GC376 against CV777 and YN144 (two PEDV strains) were 11.18 and 14.63 μM, respectively implying that GC376 should efficiently inhibit the replication of different PEDV strains. Compared with the non-drug-treated cells, GC376 reduced virus infection at 1.56 μM. It almost completely inhibited virus replication at approximately 6.25 μM, and cell syncytosis disappeared; 12.5 μM GC376 abolished the infection^[1].
作用机制GC376 inhibits PEDV replication by blocking the catalytic residues and binding pocket of 3CL^pro^[1].
参考文献

[1] Ye G, Wang X, Tong X, Shi Y, Fu ZF, Peng G. Structural Basis for Inhibiting Porcine Epidemic Diarrhea Virus Replication with the 3C-Like Protease Inhibitor GC376. Viruses. 2020;12(2):240

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.9703 mL
- 9.8516 mL
- 19.7032 mL
- 5 mM
- 0.3941 mL
- 1.9703 mL
- 3.9406 mL
- 10 mM
- 0.1970 mL
- 0.9852 mL
- 1.9703 mL

技术信息

CAS号	1416992-39-6	储存条件	粉末 Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C21H30N3NaO8S	运输	蓝冰
分子量	507.53	别名	GC376 sodium

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Sodium (2S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-4-methylpentanamido)-1-hydroxy-3-(2-oxopyrrolidin-3-yl)propane-1-sulfonate Catalog No. CSN25342

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