|5-(4-羟基苯乙基)苯-1,3-二醇|CsnPharm

CAS No.: 58436-28-5

Dihydroresveratrol/二氢白藜芦醇 Catalog No. CSN27510

Synonyms: 3,4',5-Trihydroxybibenzyl;5-Trihydroxybibenzyl;DHRSV

Dihydroresveratrol, a potent phytoestrogen, is a hormone receptor modulator. Dihydroresveratrol exhibits proliferative effects in androgen-independent prostate and breast cancer cells at picomolar and nanomolar concentrations.

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生物活性

描述Dihydroresveratrol has been identified as a phytoalexin in Orchidaceae, in Cannabis sativaL., and in the tuber of Dioscorea dumetorum, where its production seems to be elicited by fungal infection^[2]. As a well-known metabolite of transresveratrol formed in the intestine, dihydroresveratrol is a potent phytoestrogen that acts as a hormone receptor modulator. Dihydroresveratrol demonstrated strong proliferative properties in hormone-dependent cell lines (such as MCF-7) at picomolar (10^-12 M) concentrations. At high concentrations (1×10^-5 to 1×10^-3 M), dihydroresveratrol showed a typical decrease in the growth rate of both PC-3 prostate cancer cells and DU-145 tumor cells. However, treatment with 1×10^-10 to 1×10^-8 M of dihydroresveratrol significantly increased the growth of both the same cells indicating dihydroresveratrol having a biphasic effect^[3].
参考文献

[1] Anisimova NY, et al. Trans-, cis-, and dihydro-resveratrol: a comparative study. Chem Cent J. 2011 Dec 20;5:88.
[2] Juan ME, Alfaras I, Planas JM. Determination of dihydroresveratrol in rat plasma by HPLC. J Agric Food Chem. 2010 Jun 23;58(12):7472-5.
[3] Anisimova NY, Kiselevsky MV, Sosnov AV, Sadovnikov SV, Stankov IN, Gakh AA. Trans-, cis-, and dihydro-resveratrol: a comparative study. Chem Cent J. 2011 Dec 20;5:88.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.3429 mL
- 21.7147 mL
- 43.4293 mL
- 5 mM
- 0.8686 mL
- 4.3429 mL
- 8.6859 mL
- 10 mM
- 0.4343 mL
- 2.1715 mL
- 4.3429 mL

技术信息

CAS号	58436-28-5	储存条件	粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C14H14O3	运输	蓝冰
分子量	230.26	别名	3,4',5-Trihydroxybibenzyl;5-Trihydroxybibenzyl;DHRSV;二氢白藜芦醇

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Dihydroresveratrol/二氢白藜芦醇 Catalog No. CSN27510

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