CAS No.: 1265917-14-3
S1RA HCl Catalog No. CSN17645
Synonyms: E-52862 hydrochloride;E 52862 HCl;S1RA (hydrochloride)
S1RA HCl is a potent and selective sigma-1 receptor (σ1R, Ki=17 nM) antagonist, showed good selectivity against σ2R (Ki > 1000 nM).
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Diaz JL, Cuberes R, et al. Synthesis and biological evaluation of the 1-arylpyrazole class of σ(1) receptor antagonists: identification of 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy] ethyl}morpholine (S1RA, E-52862). J Med Chem. 2012 Oct 11;55(19):8211-24.
- [2] Romero L, Zamanillo D, et al. Pharmacological properties of S1RA, a new sigma-1 receptor antagonist that inhibits neuropathic pain and activity-induced spinal sensitization. Br J Pharmacol. 2012 Aug;166(8):2289-306.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1265917-14-3 | 储存条件 |
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| 分子式 | C20H24ClN3O2 | 运输 | 蓝冰 | |
| 分子量 | 373.88 | 别名 | E-52862 hydrochloride;E 52862 HCl;S1RA (hydrochloride);E-52862;P 027;S1RA;MR-390 |
