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GPCR
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN13936 | TUG-891 | 1374516-07-0 | TUG-891 is a selective agonist of long chain free fatty acid (LCFA) receptor 4 (GPR120). |
| CSN13717 | TGR5 Receptor Agonist | 1197300-24-5 | TGR5 receptor agonist, a potent TGR5 (GPCR19) agonist, showed improved potency in the U2-OS cell assay (pEC50 = 6.8) and in melanophore cells (pEC50 = 7.5). |
| CSN15825 | TAK-875 Hemihydrate | 1374598-80-7 | TAK-875 is a selective GPR40 agonist with EC50 of 14 nM in human GPR40 expressing CHO cell line, 400-fold more potent than oleic acid. |
| CSN13586 | (S)-2-(6-((2',6'-Dimethyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid | 1000413-72-8 | TAK-875 is a potent, selective and orally bioavailable GPR40 agonist with EC50 of 0.072 μM. |
| CSN16413 | PSN632408 | 857652-30-3 | PSN632408 is an optimized agonist of GPR119 receptors that shows similar potency to OEA at both recombinant mouse and human GPR119 receptors, exhibiting EC50 values of 5.6 and 7.9 μM, respectively. |
| CSN17281 | NIBR189 | 1599432-08-2 | NIBR189 is a potent and selective EBI2 (GPR183) receptor antagonist with IC50 value of 11nM. |
| CSN16921 | MK-6892 | 917910-45-3 | MK-6892 is a highly potential GPR109A agonist with Ki value of 4.0 nM. |
| CSN16084 | MBX-2982 | 1037792-44-1 | MBX-2982 is a selective, orally-available GPR119 agonist for the treatment of type 2 tiabetes. |
| CSN11273 | Latanoprost | 130209-82-4 | Latanoprost is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. Latanoprost increases uveoscleral outflow and thereby reduces intraocular pressure. |
| CSN17039 | INT-777 | 1199796-29-6 | INT-777 is a potent and selective TGR5 agonist with remarkable in vivo activity (EC50=0.82 μM). |
| CSN12659 | GW9508 | 885101-89-3 | GW9508 is selective FFA1 (GPR40) agonist with pEC50 of 7.32 and stimulates insulin secretion in a glucose-sensitive manner. |
| CSN16522 | GW-1100 | 306974-70-9 | GW1100 is a selective antagonist of GPR40-mediated Ca2+ elevations in HEK293 cells stimulated by GW 9508 or linoleic acid with a pIC50 value equal to 5.99. |
| CSN16534 | GSK137647A | 349085-82-1 | GSK137647A is an agonist of FFA4 with pEC50 of 6.3. |
| CSN13558 | GSK1292263 | 1032823-75-8 | GSK1292263 is an agonist of GPR119 receptor that is used to treat type 2 diabetes. |
| CSN16256 | GPR40 Activator 2 | 1312787-30-6 | GPR40 activator 2 is a potent GPR40 activator. |
| CSN17674 | GPR40 Activator 1 | 1309435-60-6 | GPR40 activator 1 is a potent GPR40 activator for treatment of type 2 diabetes. |
| CSN17433 | GPR120 modulator 2 | 1050506-87-0 | GPR120 modulator 2 is useful for modulating G protein-coupled receptor 120 (GPR120). |
| CSN17432 | GPR120 modulator 1 | 1050506-75-6 | GPR120 modulator 1 is useful for modulating G protein-coupled receptor 120 (GPR120). |
| CSN13564 | AR 231453 | 733750-99-7 | AR 231453 is a potent and selective small molecule agonist of GPR119 that enhances glucose-dependent insulin secretion and glucagon-like peptide 1 (GLP-1) release, used as an antidiabetic agent. |
| CSN16029 | APD668 | 832714-46-2 | APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119 respectively.. |
| CSN13002 | AMG 837 | 865231-46-5 | AMG-837 is a potent GPR40 agonist (EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. |
| CSN17634 | AMG 837 calcium hydrate | 1259389-38-2 | AMG-837 Calcium is a potent GPR40 agonist (EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. |
| CSN16337 | 6-OAU | 83797-69-7 | 6-OAU is a surrogate agonist of GPR84 activating human GPR84 in the presence of Gqi5 chimera in HEK293 cells with an EC50 of 105 nM in the PI assay. |
