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CAS No.: 339-72-0

L-环丝氨酸 Catalog No. CSN16300

Synonyms: (S)-Cycloserine;(S)-4-Amino-3-isoxazolidone;(-)-Cycloserine

L-cycloserine is an inhibitor of serine palmitoyltransferase and block sphingosine biosynthesis. It has antibiotic effective against mycobacterium tuberculosis.

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描述L-Cycloserine is an irreversible inhibitor of 3-ketodihydrosphingosine synthetase, which is the first enzyme of the sphingolipid pathway, and causes the synthesis of sphingolipids to decrease^[3]. L-cycloserine injected subcutaneously in young mice have shown that cerebroside synthesis is inhibited specifically. It is also resulted in significant reduction in brain cerebroside level with low-dose injection for two month; liver and spleen glucocerebroside levels were also significantly reduced^[4]. L-Cycloserine inhibited the activity of gamma-aminobutyric acid (GABA)-transaminase (GABA-T) and elevated the level of GABA in whole mouse brain with a peak effect 3-4 hr after injection. L-Cycloserine (10-30 mg/kg, p.o. or i.p.) prevented tonic seizures induced by 3-mercaptopropionic acid (3-MPA) and audiogenic seizures in DBA/2 mice. Similarly, small doses of L-cycloserine reduced the level of cGMP in the cerebellum of rats. Larger doses of L-cycloserine (greater than 30-100 mg/kg) impaired the performance of mice in the rotarod, chimney and horizontal wire tests, and reduced spontaneous locomotor activity of rats^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 9.7951 mL
- 48.9755 mL
- 97.9510 mL
- 5 mM
- 1.9590 mL
- 9.7951 mL
- 19.5902 mL
- 10 mM
- 0.9795 mL
- 4.8975 mL
- 9.7951 mL

技术信息

CAS号	339-72-0	储存条件	粉末 Keep in dark place,Inert atmosphere,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C3H6N2O2	运输	蓝冰
分子量	102.09	别名	(S)-Cycloserine;(S)-4-Amino-3-isoxazolidone;(-)-Cycloserine;L-4-amino 3-Isoxazolidinone;Levcycloserine;Cyclo-L-serine;Levcicloserina;L-Oxamicina;BRN 0080799;L-环丝氨酸

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