CAS No.: 851881-60-2
ADX-47273 Catalog No. CSN16339
Synonyms: BA 94673139
ADX-47273 is a positive allosteric modulator of mGlu5 receptor with EC50 value of 0.23 μM in primary astrocyte culture.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Liu F, Grauer S, et al. ADX47273[S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4] -oxadiazol-5-yl] -piperidin-1-yl}-methanone] : a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities. J Pharmacol Exp Ther. 2008 Dec;327(3):827-39.
- [2] de Paulis T, Hemstapat K, et al. Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes. J Med Chem.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 851881-60-2 | 储存条件 |
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| 分子式 | C20H17F2N3O2 | 运输 | 蓝冰 | |||||
| 分子量 | 369.36 | 别名 | BA 94673139 | |||||
| 溶解度 |
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动物实验配方 |
