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| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN17422 | Dexpramipexole 2HCl | 104632-27-1 | Dexpramipexole 2HCl is the HCl form of Dexpramipexole which is a non-ergoline dopamine agonist for treatment of parkinson's disease and restless leg syndrome.Dexpramipexole is an (R)-(+) optical enantiomer of pramipexole. |
| CSN17520 | Rapastinel | 117928-94-6 | Rapastinel is a putative NMDAR functional glycine-site partial agonist. |
| CSN17769 | KML29 | 1380424-42-9 | KML29 is a highly selective and potent MAGL inhibitor with IC50s for 15, 43, and 5.9 nM in mouse, rat, and human brain proteomes, respectively. |
| CSN17796 | GV-58 | 1402821-41-3 | GV-58 is a potent, selective N- and P/Q-type Ca2+ channels agonist with EC50 of 7.21/8.81 μM for N-type/P-Q-type Ca2+ channel and 20-fold less potent CDK inhibitor activity. |
| CSN17694 | CZC-25146 HCl | 1330003-04-7 | CZC-25146 HCl is a potent, selective and metabolically stable LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2 respectively. |
| CSN17400 | ARN2966 | 102212-26-0 | ARN2966 is a potent post-transcriptional modulator of APP expression and reduces expression of APP with resultant lower production of Aβ. |
| CSN17609 | Balipodect | 1238697-26-1 | TAK-063 is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM, displaying > 15000-fold selectivity over other PDEs. |
| CSN17660 | Nirogacestat | 1290543-63-3 | PF-3084014 is a reversible inhibitor of γ-secretase with IC50 of 6.2 nM. |
| CSN17606 | ABT-639 | 1235560-28-7 | ABT-639 is a peripherally acting, selective T-type Ca2+ channel blocker. |
| CSN17450 | PDE-9 inhibitor | 1082743-70-1 | PDE-9 inhibitor is useful for neurodegenerative diseases. |
| CSN17779 | Vigabatrin HCl | 1391054-02-6 | Vigabatrin HCl is a structural analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transaminase. |
| CSN17719 | LY2795050 | 1346133-08-1 | LY2795050 is a selective κ-opioid Receptor (KOR) antagonist (IC50=0.72 nM) and has the potential as a PET tracer to image KOR in vivo. |
| CSN17650 | CGP-42112 | 127060-75-7 | CGP-42112 is a potent Angiotensin-II subtype 2 receptor (AT2 R) agonist. |
| CSN17469 | (R)-1-(1-(1-Methylcyclooctyl)piperidin-4-yl)-2-(piperidin-3-yl)-1H-benzo[d]imidazole trihydrochloride | 1108147-88-1 | MCOPPB 3HCl is a nociceptin receptor agonist with pKi of 10.07, displaying weaker activity at other opioid receptors. |
| CSN17505 | Tarafenacin D-tartrate | 1159101-48-0 | Tarafenacin D-tartrate is a highly selective M3 muscarinic receptor antagonist (Ki= 0.19 nM), ~200 fold selectivity over M2 receptor. |
| CSN17690 | (S)-(-)-5-Fluorowillardiine HCl | 1321546-70-6 | (S)-(-)-5-Fluorowillardiine HCl is a potent and specific AMPAR agonist. |
| CSN17513 | gamma-secretase modulator 1 | 1172637-87-4 | gamma-Secretase modulator 1 is a gamma-secretase modulator useful for Alzheimer's disease. |
| CSN17461 | gamma-secretase modulator 2 | 1093978-89-2 | gamma-Secretase modulator 2 is a potent and selective γ-secretase modulator for treatment of Alzheimer's disease. |
| CSN17602 | (R)-4-Chloro-N-(quinuclidin-3-yl)benzamide hydrochloride | 123464-89-1 | PNU-282987 is a selective α7 nAChR agonist with ki value of 26nM and displays almost no effect on α1β1γδ and α3β4 nAChRs. |
| CSN17518 | Agomelatine HCl | 1176316-99-6 | Agomelatine HCl is an antidepressant, which is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. |
| CSN17681 | Ro 25-6981 Maleate | 1312991-76-6 | Ro 25-6981 maleate is a potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit. |
| CSN17656 | Ro 41-1049 HCl | 127917-66-2 | Ro 41-1049 HCl is a selective, reversible, orally-active MAO-A inhibitor. |
| CSN17500 | ST-836 | 1148156-63-1 | ST-836 is a dopamine receptor ligand and an antiparkinsonian agent. |
| CSN17590 | MK-7622 | 1227923-29-6 | M1 receptor modulator is a muscarinic M1 receptor positive allosteric modulator. |
| CSN17376 | A-867744 | 1000279-69-5 | A-867744 is a positive allosteric modulator of α7 nAChRs (IC50 values are 0.98 and 1.12 μM for human and rat α7 receptor ACh-evoked currents respectively, in X. |
| CSN17506 | (6AR,9aS)-2-(4-(6-Fluoropyridin-2-yl)benzyl)-5-methyl-3-(phenylamino)-5,6a,7,8,9,9a-hexahydrocyclopenta[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one | 1160521-50-5 | ITI-214 free base is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = 58 pM). |
| CSN17398 | (Rac)-Rotigotine HCl | 102120-99-0 | rac-Rotigotine HCl is a high potency and selectivity agonist for D-2 receptor with Ki of 0.69 nM. |
| CSN17529 | Zileuton sodium | 118569-21-4 | Zileuton sodium is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation. |
| CSN17697 | Nav1.7-IN-2 | 1332295-35-8 | Nav1.7-IN-2 is an inhibitor of voltage-gated sodium channels (Nav), in particular Nav 1.7, with IC50 of 80 nM. |
| CSN17481 | JNJ-40411813 | 1127498-03-6 | JNJ-40411813 is a positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM. |
| CSN17791 | BAN ORL 24 | 1401463-54-4 | BAN ORL 24 is a potent and selective NOP receptor antagonist. (IC50 values are 0.27, 2500, 6700 and > 10000 nM for NOP, κ-, μ- and δ-receptors respectively). |
| CSN17428 | Entacapone sodium salt | 1047659-02-8 | Entacapone sodium is a specific, potent, peripherally acting catechol-O-methyltransferase (COMT) inhibitor with IC50 of 151 nM for PD treatment. |
| CSN17444 | rel-(2R,3'R)-2-Methyl-1'-azaspiro[[1,3]oxathiolane-5,3'-bicyclo[2.2.2]octane] hydrochloride | 107220-28-0 | Cevimeline HCl is a parasympathomimetic and muscarinic agonist, with particular effect on M3 receptors and used in the treatment of dry mouth associated with sjogren's syndrome. |
| CSN17480 | Tandospirone citrate | 112457-95-1 | Tandospirone citrate is a potent and selective 5-HT1A receptor partial agonist (Ki = 27 nM) that displays selectivity over SR-2, SR-1C, α1, α2, D1 and D2 receptors (Ki values ranging from 1300-41000 nM). |
| CSN17671 | L-655708 | 130477-52-0 | L-655708 is a potent α5 subunit-selective GABAA receptor inverse agonist (Ki = 0.45 nM). |
| CSN17585 | Naspm | 122306-11-0 | Naspm is a potent and selective Ca2+ permeable AMPA receptor (Ca-perm AMPAR) blocker. |
| CSN17645 | S1RA HCl | 1265917-14-3 | S1RA HCl is a potent and selective sigma-1 receptor (σ1R, Ki=17 nM) antagonist, showed good selectivity against σ2R (Ki > 1000 nM). |
| CSN17630 | Fanapanel hydrate | 1255517-78-2 | ZK200775 is a highly selective AMPA/kainate antagonist with little activity against NMDA and has Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively. |
| CSN17467 | (4-Cyclopropylpiperazin-1-yl)(4-(morpholinomethyl)phenyl)methanone dihydrochloride hydrate | 1103522-80-0 | Bavisant HCl is a highly selective, orally active antagonist of the human H3 receptor with a mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD. |
| CSN17519 | Felbamate hydrate | 1177501-39-1 | Felbamate is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA) . |
| CSN17482 | SR-3306 | 1128096-91-2 | SR-3306 is a brain penetrant small molecule JNK inhibitor from the aminopyrimidine class. |
| CSN17580 | (-)-Dizocilpine maleate | 121917-57-5 | (-)-MK 801 maleate is the enantiomer of (+)-MK-801, which is a highly potent and selective non-competitive NMDA glutamate receptor antagonist . |
| CSN17706 | BMS-5 | 1338247-35-0 | BMS-5 is a highly selective and potent inhibitor of both LIMK 1 and 2 with IC50 values of 7 and 8 nM, respectively. |
