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CAS No.: 103639-04-9

盐酸昂丹司琼二水物 Catalog No. CSN15871

Synonyms: GR 38032 hydrochloride dihydrate;SN 307 hydrochloride dihydrate;GR 38032 HCl 2H2O

Ondansetron HCl 2H2O is a competitive 5-HT3 receptor antagonist.

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技术信息

生物活性

描述Ondansetron Hydrochloride Dihydrate is the hydrated state of Ondansetron hydrochloride. Ondansetron is a selective 5-hydroxytryptamine3 (5-HT3) receptor antagonist as an antiemetic for cancer treatment-induced and anesthesia-related nausea and vomiting^[3]. 5-HT evoked transient inward currents (EC₅₀ = 3.4 mM; Hill coefficient = 1.8) that were blocked by the 5-HT3 receptor antagonist ondansetron (IC50 = 103 pM)^[4]. Indirect stimulation of nicotinic acetylcholine receptor by ondansetron can improve the auditory gating parameters of DBA/2 mice^[5]. Different doses of ondansetron were injected intraperitoneally (i.p.) at fixed times during the day to determine both the sublethal (TD50) and lethal (LD50) doses, which were, 3.7 +/- 0.6 mg/kg and 4.6 +/- 0.5 mg/kg, respectively^[6].
细胞研究

Cell Data

Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
CHO cells	-	Function assay	-	Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique, IC50=0.81283 μM	18448342
HEK cells	-	Function assay	-	Inhibition of human ERG expressed in HEK cells by patch clamp technique, IC50=0.4 μM	20889341
HEK293 cells	-	Function assay	-	Displacement of [3H]granisetron from human 5HT3A receptor expressed in HEK293 cells by filter binding assay, Ki=0.0028 μM	21486038

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临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01511705	Healthy	Phase 1	Completed	-	India ... more >> Vimta Labs Limited Hyderabad, Andhra Pradesh, India, 500 051 Collapse <<
NCT01511718	Healthy	Phase 1	Completed	-	India ... more >> Vimta Labs Limited Hyderabad, Andhra Pradesh, India, 500 051 Collapse <<
NCT02028910	Vomiting Gast... more >>roenteritis Collapse <<	Phase 3	Terminated	-	France ... more >> Vincent Gajdos Clamart, France, 92141 Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.7334 mL
- 13.6668 mL
- 27.3336 mL
- 5 mM
- 0.5467 mL
- 2.7334 mL
- 5.4667 mL
- 10 mM
- 0.2733 mL
- 1.3667 mL
- 2.7334 mL

技术信息

CAS号

103639-04-9

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C18H24ClN3O3

运输

蓝冰

分子量

365.85

别名

GR 38032 hydrochloride dihydrate;SN 307 hydrochloride dihydrate;GR 38032 HCl 2H2O;SN-307 HCl 2H2O;NSC665799 HCl 2H2O;Ondansetron (hydrochloride hydrate);盐酸昂丹司琼二水物

溶解度

DMSO	70.0 mg/mL (191.3 mM) warming
Water	80.0 mg/mL (218.7 mM) warming

动物实验配方

0.5% CMC-Na

52 mg/mL

suspension

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