CAS No.: 286456-42-6
L-838417 Catalog No. CSN15698
L-838417 is a subtype-selective GABAA receptor partial agonist. L-838417 selectively binds to α1, α2, α3 and α5 subunits (Ki values are 0.79, 0.67, 0.67 and 2.25 nM respectively) but displays no efficacy at α1 (α1-sparing). L-838417 exhibits non-sedative anxiolytic, antinociceptive and anti-inflammatory activity.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] McMahon LR, France CP. Differential behavioral effects of low efficacy positive GABAA modulators in combination with benzodiazepines and a neuroactive steroid in rhesus monkeys. Br J Pharmacol. 2006 Feb;147(3):260-8.
- [2] McCabe C, Shaw D, et al. Subtype-selective GABAergic drugs facilitate extinction of mouse operant behaviour. Neuropharmacology. 2004 Feb;46(2):171-8.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 286456-42-6 | 储存条件 |
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| 分子式 | C19H19F2N7O | 运输 | 蓝冰 | |
| 分子量 | 399.40 | 别名 |
