CAS No.: 913611-97-9
Brexpiprazole/依匹哌唑 Catalog No. CSN15692
Synonyms: OPC-34712;brand name Rexulti;依匹哌唑
Brexpiprazole is a partial agonist of the serotonin 5-HT1A receptor and the dopamine D2 and D3 receptors, used as an atypical antipsychotic for the treatment of schizophrenia and major depressive disorders.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
靶点 5-HT Receptor 1A
Ki:0.12nM5-HT Receptor 2A
Ki:0.47nMAdrenergic Receptor α1B
Ki:0.17nMAdrenergic Receptor α2C
Ki:0.59nMDopamine Receptor D2L
Ki:0.13nM- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT01393613 - - Completed - - NCT01393613 Acute Schizophrenia Phase 3 Completed - - NCT01447576 Major Depressive Disorder Phase 2 Completed - - - 更多
- 参考文献
- [1] Ishima T, Futamura T, et al. Potentiation of neurite outgrowth by brexpiprazole, a novel serotonin-dopamine activity modulator: a role for serotonin 5-HT1A and 5-HT2A receptors. Eur Neuropsychopharmacol. 2015 Apr;25(4):505-11.
- [2] Yoshimi N, Fujita Y, et al. Effects of brexpiprazole, a novel serotonin-dopamine activity modulator, on phencyclidine-induced cognitive deficits in mice: a role for serotonin 5-HT1A receptors. Pharmacol Biochem Behav. 2014 Sep;124:245-9.
- [3] Oosterhof CA, El Mansari M, Bundgaard C, Blier P. Brexpiprazole Alters Monoaminergic Systems following Repeated Administration: an in Vivo Electrophysiological Study. Int J Neuropsychopharmacol. 2015 Oct 1;19(3):pyv111.
- [4] Ma M, Ren Q, Yang C, Zhang JC, Yao W, Dong C, Ohgi Y, Futamura T, Hashimoto K. Adjunctive treatment of brexpiprazole with fluoxetine shows a rapid antidepressant effect in social defeat stress model: Role of BDNF-TrkB signaling. Sci Rep. 2016 Dec 19;6:39209.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 913611-97-9 | 储存条件 |
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| 分子式 | C25H27N3O2S | 运输 | 蓝冰 | |||||||
| 分子量 | 433.57 | 别名 | OPC-34712;brand name Rexulti;依匹哌唑 | |||||||
| 溶解度 |
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动物实验配方 |
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
|---|
| NCT01393613 | - | - | Completed | - | - |
| NCT01393613 | Acute Schizophrenia | Phase 3 | Completed | - | - |
| NCT01447576 | Major Depressive Disorder | Phase 2 | Completed | - | - |
| NCT01423916 | Schizophrenia ... more >> Schizoaffective Disorder Collapse << | Phase 1 | Completed | - | United States, California ... more >> Otsuka Investigational Site Long Beach, California, United States, 90806 Otsuka Investigational Site San Diego, California, United States, 92102 United States, Florida Otsuka Investigational Site Fort Lauderdale, Florida, United States, 33308 United States, Kansas Otsuka Investigational Site Overland Park, Kansas, United States, 66212 United States, Maryland Otsuka Investigational Site Rockville, Maryland, United States, 20850 United States, Missouri Otsuka Investigational Site St. Louis, Missouri, United States, 63118 United States, Pennsylvania Otsuka Investigational Site Philadelphia, Pennsylvania, United States, 19139 United States, Texas Otsuka Investigational Site Austin, Texas, United States, 78754 Collapse << |
| NCT01423916 | - | - | Completed | - | - |
| NCT03557931 | Schizophrenia | Phase 2 | Recruiting | December 2019 | United States, Arkansas ... more >> Woodland Research Northwest, LLC Recruiting Rogers, Arkansas, United States, 72758 United States, California CNS Research Science, Inc. Recruiting Cerritos, California, United States, 90703 Collaborative Neuroscience Network, LLC Recruiting Garden Grove, California, United States, 92845 Synergy East Recruiting Lemon Grove, California, United States, 91945 Pacific Research Partners, LLC Recruiting Oakland, California, United States, 94607 California Neuropsychopharmacology Clinical Research Institute-LA, LLC Recruiting Pico Rivera, California, United States, 90660 Artemis Institute for Clinical Research Recruiting San Diego, California, United States, 92103 Sharp Mesa Vista Hospital Recruiting San Diego, California, United States, 92123 Collaborative Neuroscience Network, LLC Recruiting Torrance, California, United States, 90502 United States, Georgia Radiant Research, Inc. Recruiting Atlanta, Georgia, United States, 30328 Atlanta Center for Medical Research Recruiting Atlanta, Georgia, United States, 30331 United States, Illinois Alam Medical Research Inc. Recruiting Chicago, Illinois, United States, 60612 Uptown Research Institute Recruiting Chicago, Illinois, United States, 60640 United States, Michigan Michigan Clinical Research Institute PC Recruiting Ann Arbor, Michigan, United States, 48105 Cherry Street Services, Inc. Recruiting Grand Rapids, Michigan, United States, 49503 United States, New Jersey Hassman Research Institute Recruiting Berlin, New Jersey, United States, 08009 United States, New Mexico Albuquerque Neuroscience Inc. Recruiting Albuquerque, New Mexico, United States, 87109 United States, New York SPRI Clinical Trials, LLC Recruiting Brooklyn, New York, United States, 11235 CNS Research Science, Inc. Recruiting Jamaica, New York, United States, 11432 Manhattan Psychiatric Center's 125th Street Clinic Recruiting New York, New York, United States, 10035 United States, Ohio Midwest Clinical Research Center Recruiting Dayton, Ohio, United States, 45417 United States, Texas InSite Clinical Research, LLC Recruiting DeSoto, Texas, United States, 75115 Pillar Clinical Research, LLC Recruiting Garland, Texas, United States, 75042 Pillar Clinical Research, LLC Recruiting Richardson, Texas, United States, 75080 Collapse << |
| NCT01447576 | - | - | Completed | - | - |
| NCT01360632 | Depressive Disorder ... more >> Depression Depressive Disorder, Major Mood Disorders Mental Disorders Collapse << | Phase 3 | Completed | - | - |
| NCT01360632 | - | - | Completed | - | - |
| NCT01360645 | Depressive Disorder ... more >> Depression Depressive Disorder, Major Mood Disorders Mental Disorders Collapse << | Phase 3 | Completed | - | - |
| NCT01289080 | Schizophrenia ... more >> Psychiatric Disorders Collapse << | Phase 1 | Completed | - | United States, Florida ... more >> Otsuka Investigational Site Miami, Florida, United States, 33014 United States, Minnesota Otsuka Investigational Site Minneapolis, Minnesota, United States, 55404 Collapse << |
| NCT01299454 | Schizophrenia | Phase 1 | Completed | - | United States, Florida ... more >> Study Site Miami, Florida, United States, 33014 United States, Minnesota Study Site Minneapolis, Minnesota, United States, 55404 United States, Texas Study Site San Antonio, Texas, United States, 78212 Collapse << |
| NCT01360645 | - | - | Completed | - | - |
| NCT01299454 | - | - | Completed | - | - |
| NCT01289080 | - | - | Completed | - | - |
| NCT01396421 | Acute Schizophrenia | Phase 3 | Completed | - | - |
| NCT00797966 | - | - | Completed | - | - |
| NCT00797966 | Major Depressive Disorder | Phase 2 | Completed | - | - |
| NCT01360866 | Depressive Disorder ... more >> Depression Depressive Disorder, Major Mood Disorders Mental Disorders Collapse << | Phase 3 | Completed | - | - |
| NCT01396421 | - | - | Completed | - | - |
| NCT02192554 | - | - | Completed | - | - |
| NCT01360866 | - | - | Completed | - | - |
| NCT03033069 | Stress Disorders, Post-Traumat... more >>ic Collapse << | Phase 2 | Active, not recruiting | November 23, 2018 | - |
| NCT03538691 | Major Depressive Disorder | Phase 3 | Recruiting | September 2022 | - |
| NCT02875080 | Healthy Adult Male | Phase 1 | Completed | - | Japan ... more >> Kyusyu Region, Japan Collapse << |
| NCT01670279 | Major Depressive Disorder | Phase 1 | Completed | - | United States, Florida ... more >> Accurate Clinical Trials Kissimmee, Florida, United States Miami Jewish Health System Miami, Florida, United States United States, Missouri St. Louis Clinical Trials St. Louis, Missouri, United States United States, Pennsylvania CRI Lifetree- Philadelphia Research Center Philadelphia, Pennsylvania, United States Collapse << |
| NCT01810380 | Schizophrenia | Phase 3 | Completed | - | United States, California ... more >> US009 Escondido, California, United States, 92025 Collapse << |
| NCT02411695 | Schizophrenia | Phase 1 | Completed | - | United States, Arkansas ... more >> Little Rock, Arkansas, United States, 72211 United States, California Culver City, California, United States, 90230 Orange, California, United States, 92858 United States, District of Columbia Washington, District of Columbia, United States, 20016 United States, Georgia Atlanta, Georgia, United States, 30331 United States, New Jersey Marlton, New Jersey, United States, 08053 United States, Ohio Cincinnati, Ohio, United States, 45219 Cleveland, Ohio, United States, 44106 United States, Texas The Woodlands, Texas, United States, 77381 United States, Utah Orem, Utah, United States, 84058 Collapse << |
| NCT01838681 | Major Depressive Disorder | Phase 3 | Completed | - | - |
| NCT01810380 | - | - | Completed | - | - |
| NCT01837797 | - | - | Terminated(The study was termi... more >>nated because of recruitment challenges) Collapse << | - | - |
| NCT02054702 | Schizophrenia | Phase 3 | Completed | - | - |
| NCT03198078 | Schizophrenia | Phase 3 | Recruiting | April 2020 | - |
| NCT03548584 | Agitaton Associated With Alzhe... more >>imer's Dementia Alzheimer Dementia Collapse << | Phase 3 | Recruiting | December 2020 | - |
| NCT01670279 | - | - | Completed | - | - |
| NCT01987960 | Post-traumatic Stress Disorder... more >> PTSD Collapse << | Phase 3 | Terminated(The study was termi... more >>nated due to challenges with patient eligibility; the decision to terminate was not based on any safety concerns) Collapse << | - | - |
| NCT01987960 | - | - | Terminated(The study was termi... more >>nated due to challenges with patient eligibility; the decision to terminate was not based on any safety concerns) Collapse << | - | - |
| NCT03620981 | Agitation Associated With Deme... more >>ntia of the Alzheimer's Type Collapse << | Phase 2 Phase 3 | Recruiting | November 2021 | Japan ... more >> Yoyogi Mental Clinic Recruiting Tokyo, Japan Collapse << |
| NCT01838681 | - | - | Completed | - | - |
| NCT02968121 | Schizophrenia | Phase 1 | Terminated(Part A of study was... more >> completed per protocol. Conduct of Part B of the study (confirmatory phase) was not necessary.) Collapse << | - | United States, California ... more >> Collaborative Neuro Science (CNS) Garden Grove, California, United States, 92845 CNRI San Diego, California, United States, 92102 Collapse << |
| NCT01837797 | Major Depressive Disorder | Phase 3 | Terminated(The study was termi... more >>nated because of recruitment challenges) Collapse << | - | United States, California ... more >> US001 National City, California, United States, 91950 United States, Florida US008 Orlando, Florida, United States, 32806 Collapse << |
| NCT02013609 | MDD | Phase 3 | Completed | - | United States, California ... more >> Cerritos, California, United States, 90703 Costa Mesa, California, United States, 92626 Garden Grove, California, United States, 92845 Glendale, California, United States, 91206 Orange, California, United States, 92868 Riverside, California, United States, 92506 San Diego, California, United States, 92121 United States, Connecticut Norwich, Connecticut, United States, 06360 United States, Florida Fort Myers, Florida, United States, 33912 Hialeah, Florida, United States, 33016 Melbourne, Florida, United States, 32901 Orlando, Florida, United States, 32806 United States, Georgia Atlanta, Georgia, United States, 30328 United States, Kansas Prairie Village, Kansas, United States, 66206 United States, Massachusetts Weymouth, Massachusetts, United States, 02190 United States, Nevada Las Vegas, Nevada, United States, 89102 United States, New York Brooklyn, New York, United States, 11235 Jamaica, New York, United States, 11235 Staten Island, New York, United States, 10312 United States, Oregon Portland, Oregon, United States, 97210 United States, Texas Austin, Texas, United States, 78731 Houston, Texas, United States, 77007 San Antonio, Texas, United States, 78229 United States, Washington Seattle, Washington, United States, 98104 Collapse << |
| NCT01727726 | - | - | Completed | - | - |
| NCT02013609 | - | - | Completed | - | - |
| NCT02013622 | - | - | Completed | - | - |
| NCT02400346 | - | - | Completed | - | - |
| NCT02054702 | - | - | Completed | - | - |
| NCT01922258 | Agitation Associated With ... more >> Alzheimer's Disease Alzheimer's Type Mental Disorder Nervous System Diseases Collapse << | Phase 3 | Completed | - | - |
| NCT01727726 | Depressive Disorder ... more >> Depression Depressive Disorder, Major Mood Disorders Mental Disorders Collapse << | Phase 3 | Completed | - | - |
| NCT02400346 | Major Depression Disorder | Phase 3 | Completed | - | - |
| NCT02013531 | Major Depressive Disorder ... more >> Anxiety Collapse << | Phase 3 | Completed | - | United States, Arizona ... more >> Tuscon, Arizona, United States, 85712 United States, California Garden Grove, California, United States, 92845 Oceanside, California, United States, 92056 Temecula, California, United States, 92591 United States, Florida Gainesville, Florida, United States, 32607 Jacksonville, Florida, United States, 32256 Miami, Florida, United States, 33145 United States, Georgia Atlanta, Georgia, United States, 30308 United States, Indiana Lafayette, Indiana, United States, 47905 United States, Maryland Baltimore, Maryland, United States, 21208 United States, Massachusetts Boston, Massachusetts, United States, 02131 Haverhill, Massachusetts, United States, 01830 United States, Michigan Rochester Hills, Michigan, United States, 48307 United States, New York New York, New York, United States, 10168 Staten Island, New York, United States, 10305 United States, Oregon Salem, Oregon, United States, 97301 United States, Pennsylvania Allentown, Pennsylvania, United States, 18104 United States, Texas Arlington, Texas, United States, 76012 Austin, Texas, United States, 78731 United States, Vermont Woodstock, Vermont, United States, 05091 United States, Virginia Richmond, Virginia, United States, 23230 Collapse << |
| NCT01862640 | Agitation Associated With ... more >> Alzheimer's Disease Alzheimer's Type Mental Disorder Nervous System Diseases Collapse << | Phase 3 | Completed | - | - |
| NCT02013622 | Schizophrenia | Phase 3 | Completed | - | United States, California ... more >> Cerritos, California, United States, 90703 Chula Vista, California, United States, 92105 Costa Mesa, California, United States, 92626 Long Beach, California, United States, 90806 Oakland, California, United States, 94612 Oceanside, California, United States, 92056 Pico Rivera, California, United States, 90660 Riverside, California, United States, 92506 San Diego, California, United States, 92102 San Diego, California, United States, 92123 Santa Ana, California, United States, 92705 Torrance, California, United States, 90502 United States, Florida Fort lauderdale, Florida, United States, 33334 United States, Georgia Atlanta, Georgia, United States, 30308 United States, Illinois Hoffman Estates, Illinois, United States, 60169 United States, Louisiana Lake Charles, Louisiana, United States, 70629 United States, New York Rochester, New York, United States, 14618 United States, Pennsylvania Philadelphia, Pennsylvania, United States, 19139 United States, Tennessee Memphis, Tennessee, United States, 38119 United States, Texas Dallas, Texas, United States, 75231 Dallas, Texas, United States, 75243 Houston, Texas, United States, 77007 Collapse << |
| NCT01668797 | Acute Schizophrenia | Phase 3 | Completed | - | - |
| NCT02012218 | Major Depressive Disorder (MDD... more >>) Collapse << | Phase 3 | Completed | - | - |
| NCT02013531 | - | - | Completed | - | - |
| NCT01668797 | - | - | Completed | - | - |
| NCT02012218 | - | - | Completed | - | - |
| NCT03257865 | Bipolar I Disorder ... more >> Manic Episode Collapse << | Phase 3 | Recruiting | January 2019 | - |
| NCT03259555 | Bipolar I Disorder ... more >> Manic Episode Collapse << | Phase 3 | Recruiting | January 2019 | - |
| NCT03238326 | Schizophrenia | Phase 3 | Recruiting | December 2022 | United States, New York ... more >> Finger Lakes Clinical Research Recruiting Rochester, New York, United States, 14618 Ukraine SI Institute of Neurology, Psychiatry and Narcology of NAMSU, Department of Clinical, Social and Child Psychiatry Recruiting Kharkiv, Ukraine, 61068 Collapse << |
| NCT02758067 | Schizophrenia | Phase 3 | Withdrawn(This study was withd... more >>rawn for administrative reasons. There were no safety concerns.) Collapse << | - | - |
| NCT03697603 | Major Depressive Disorder | Phase 2 Phase 3 | Recruiting | July 2022 | Japan ... more >> Nanko-kokorono clinic Recruiting Fukushima, Japan Collapse << |
| NCT01944969 | Major Depressive Disorder | Phase 3 | Terminated(The study was termi... more >>nated because the lead-in study (14571A) in elderly was terminated; see Detailed Description.) Collapse << | - | United States, Florida ... more >> US008 Orlando, Florida, United States, 32806 Collapse << |
| NCT03526354 | Schizophrenia ... more >> Schizoaffective Disorder Substance Use Disorders Collapse << | Phase 4 | Recruiting | September 19, 2020 | United States, Massachusetts ... more >> Massachusetts General Hospital Not yet recruiting Boston, Massachusetts, United States, 02114 Contact: Christopher McCain, BS Principal Investigator: Oliver Freudenreich, MD UMass Medical School Recruiting Worcester, Massachusetts, United States, 01655 Contact: Joseph Mayotte, BA Principal Investigator: Xiaoduo Fan, MD United States, North Carolina University of North Carolina Not yet recruiting Chapel Hill, North Carolina, United States, 27599 Contact: Fred Jarskog, MD Collapse << |
| NCT01944969 | - | - | Terminated(The study was termi... more >>nated because the lead-in study (14571A) in elderly was terminated; see Detailed Description.) Collapse << | - | - |
| NCT03292848 | ADHD Autism ... more >> Bipolar I Disorder Conduct Disorder Oppositional Defiant Disorder Collapse << | Phase 1 | Completed | - | United States, Arkansas ... more >> Woodland International Research Group Little Rock, Arkansas, United States, 72211 Woodland Research Northwest, LLC Rogers, Arkansas, United States, 72758 United States, California Alliance for Wellness dba Alliance for Research Long Beach, California, United States, 90807 United States, North Carolina New Hope Clinical Research Charlotte, North Carolina, United States, 28211 United States, Oklahoma IPS Research Company Oklahoma City, Oklahoma, United States, 73103 Cutting Edge Research Group Oklahoma City, Oklahoma, United States, 73116 United States, Texas Clinical Trials of Texas, Inc. San Antonio, Texas, United States, 78229 Road Runner Research Ltd. San Antonio, Texas, United States, 78249 United States, Utah Aspen Clinical Research Orem, Utah, United States, 84058 Collapse << |
| NCT03734302 | Healthy | Phase 1 | Not yet recruiting | June 30, 2019 | China, Beijing ... more >> Beijing Anding Hospital of Capital Medical University Beijing, Beijing, China, 100088 Collapse << |
| NCT01810783 | - | - | Completed | - | - |
| NCT02196506 | Depressive Disorder ... more >> Depression Depressive Disorder, Major Mood Disorders Mental Disorders Collapse << | Phase 3 | Completed | - | - |
| NCT02212613 | Major Depressive Disorder and ... more >>Irritability Collapse << | Phase 3 | Withdrawn(Low enrollment) | - | United States, Georgia ... more >> Emory University Atlanta, Georgia, United States, 30329 Collapse << |
| NCT01810783 | Schizophrenia | Phase 3 | Completed | - | - |
| NCT02196506 | - | - | Completed | - | - |
| NCT03594123 | Alzheimer Disease | Phase 3 | Recruiting | August 2021 | United States, Florida ... more >> Galiz Research, LLC Recruiting Hialeah, Florida, United States, 33016 Collapse << |
| NCT01854944 | Schizophrenia | Phase 1 | Completed | - | United States, New York ... more >> Columbia University New York, New York, United States, 10032 Collapse << |
| NCT03734354 | Health | Phase 1 | Not yet recruiting | June 30, 2019 | China, Beijing ... more >> Beijing Anding Hospital of Capital Medical University Beijing, Beijing, China, 100088 Collapse << |
| NCT01854944 | - | - | Completed | - | - |
| NCT03149991 | Depression | Phase 4 | Recruiting | January 31, 2019 | United States, California ... more >> Collaborative Neuroscience Network, LLC. Recruiting Garden Grove, California, United States, 92845 Contact: Erica O'Brien, MSW 844-949-2930 info@cnstrial.com Pacific Research Partners, LLC Recruiting Oakland, California, United States, 94607 Contact: Cheri Savercool 510-444-2877 CheriSavercool@pacifictrials.com United States, Illinois Rush University Medical Center Recruiting Chicago, Illinois, United States, 60612 Contact: Linda Skaggs 312-942-5592 Linda_Skaggs@rush.edu United States, Massachusetts Massachusetts General Hospital, Depression Clinical and Research Program Recruiting Boston, Massachusetts, United States, 02114 Contact: Taquesha Dean 617-724-3520 tdean4@partners.org Contact: Garrett A Thomas 617-724-3222 gthomas12@mgh.harvard.edu United States, New York Montefiore Medical Center Recruiting Bronx, New York, United States, 10467 Contact: Jennifer Alexander 929-429-5644 jealexan@montefiore.org Nathan Kline Institute for Psychiatric Research Recruiting Orangeburg, New York, United States, 10562 Contact: Karen Nolan, PhD 845-398-6572 nolan@nki.rfmh.org Contact: Erin McDonald 845-398-6567 Erin.McDonald@nki.rfmh.org Collapse << |
| NCT01942785 | Major Depressive Disorder ... more >> Irritability Collapse << | Phase 3 | Completed | - | United States, Arizona ... more >> US015 Tucson, Arizona, United States United States, California US019 Glendale, California, United States US016 Oakland, California, United States US014 San Diego, California, United States United States, Colorado US011 Denver, Colorado, United States United States, Florida US018 Hallandale Beach, Florida, United States US009 Jacksonville, Florida, United States US005 Orlando, Florida, United States United States, Maryland US006 Gaithersburg, Maryland, United States United States, Massachusetts US012 Weymouth, Massachusetts, United States United States, New York US003 Jamaica, New York, United States United States, Ohio US001 Dayton, Ohio, United States United States, Oregon US007 Portland, Oregon, United States United States, Tennessee US004 Memphis, Tennessee, United States United States, Washington US002 Seattle, Washington, United States Collapse << |
| NCT01942733 | Sleep Disturbances | Phase 3 | Completed | - | - |
| NCT01942785 | - | - | Completed | - | - |
| NCT03724942 | Agitation Associated With Deme... more >>ntia of the Alzheimer's Type Collapse << | Phase 3 | Recruiting | May 2021 | Japan ... more >> Jisenkai Nanko Psychiatric Institute Recruiting Shirakawa, Japan Collapse << |
| NCT03418675 | Borderline Personality Disorde... more >>r Collapse << | Phase 2 | Recruiting | April 2020 | United States, Illinois ... more >> University of Chicago Recruiting Chicago, Illinois, United States, 60637 Contact: Stephanie Valle, BA 773-834-1325 svalle@yoda.bsd.uchicago.edu Contact: Jon E Grant, JD, MD, MPH 7738341325 jongrant@uchicago.edu Collapse << |
| NCT01942733 | - | - | Completed | - | - |
| NCT02194933 | Schizophrenia With Impulsivity | Phase 3 | Completed | - | United States, California ... more >> University of California at Irvine Medical Center Orange, California, United States, 92868 Collapse << |
| NCT03487198 | Major Depressive Disorder | Phase 3 | Recruiting | November 30, 2020 | China, Beijing ... more >> Beijing Anding Hospital of Capital Medical University Recruiting Beijing, Beijing, China, 100088 Contact: Qian Zhao, MD Principal Investigator: Gang Wang, MD Collapse << |
| NCT03287869 | Bipolar I Disorder ... more >> Acute Mania Collapse << | Phase 3 | Recruiting | July 2019 | - |
| NCT02194933 | - | - | Completed | - | - |
| NCT03737474 | Major Depressive Disorder | Phase 3 | Recruiting | July 2022 | Japan ... more >> Nanko-kokorono clinic Recruiting Shirakawa, Japan Collapse << |
| NCT02934932 | Post Traumatic Stress Disorder | Phase 2 | Completed | - | United States, North Carolina ... more >> Pamela Smith Durham, North Carolina, United States, 27712 Collapse << |
| NCT03427892 | Bipolar Depression | Phase 4 | Completed | - | United States, Texas ... more >> UT Southwestern Medical Center Dallas, Texas, United States, 75390 Collapse << |
| 靶点 | Description | IC50 |
|---|---|---|
| 5-HT Receptor 1A | Ki:0.12nM | |
| 5-HT Receptor 2A | Ki:0.47nM | |
| Adrenergic Receptor α1B | Ki:0.17nM | |
| Adrenergic Receptor α2C | Ki:0.59nM | |
| Dopamine Receptor D2L | Ki:0.13nM |
