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CAS No.: 1234480-84-2
Synonyms: Leucine-rich repeat kinase 2 IN-1
LRRK2-IN-1 is a potent and selective LRRK2 inhibitor with IC50 values of 6 and 13 nM for G2019S mutant and wild-type LRRK2, respectively.
生物活性
动物研究 | |
剂量 | Mice: 100 mg/kg[3] (i.p.) |
给药途径 | i.p. |
实验方案
技术信息
CAS号 | 1234480-84-2 | 储存条件 |
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分子式 | C31H38N8O3 | 运输 | 蓝冰 | |||||||||||||
分子量 | 570.69 | 别名 | Leucine-rich repeat kinase 2 IN-1 | |||||||||||||
溶解度 |
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动物实验配方 |
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Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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HEK293 cells | - | Function assay | - | Inhibition of LRRK2 G2019S mutant expressed in HEK293 cells using nictide and ATP as substrate, IC50=0.006 μM | 22335897 |
HEK293 cells | 0.03-3 μM | Function assay | 90 mins | Inhibition of wild-type LRRK2 phosphorylation at Ser935 expressed in HEK293 cells at 0.03 to 3 uM after 90 mins by immunoblot analysis | 22335897 |
lymphoblastoid cells | 0.03 to 3 uM | Function assay | 90 mins | Inhibition of LRRK2 in human lymphoblastoid cells assessed as inhibition of Ser910 autophosphorylation at 0.03 to 3 uM after 90 mins by immunoblot method | 22863203 |
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