|4-氨基-N-(2-(二乙基氨基)乙基)苯甲酰胺盐酸盐|CsnPharm

CAS No.: 614-39-1

盐酸普鲁卡因胺 Catalog No. CSN13879

Synonyms: Procainamide Hydrochloride;Procainamide Hcl;Pronestyl

Procainamide HCl is a blocker of sodium channel and an inhibitor of DNA methyltransferase. It is an anti-arrhythmic agent.

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描述Procainamide Hydrochloride is a blocker of sodium channel and an inhibitor of DNA methyltransferase. It is an anti-arrhythmic agent. It is a medication used to manage and treat ventricular arrhythmias, supraventricular arrhythmias, atrial flutter/fibrillation, and Wolf-Parkinson-White syndrome. It is in the antiarrhythmic Agent Class 1A class of medications^[3]. Oral procainamide was associated with a significant decrease in ICD (implantable cardioverter-defibrillator) therapies and ventricular arrhythmias, showing an acceptable profile of tolerability^[4]. Treatment of endotoxemic animals with procainamide not only inhibited the increased levels of DNMT1 and 5-methylcytosine but also ameliorated neutrophil infiltration and superoxide production in the lung. Moreover, both DNMT (DNA methyltransferase) inhibitors procainamide and hydralazine improved hypotension, hypoglycemia, and multiple organ dysfunction of LPS-treated rats^[5]. Procainamide-induced autoimmunity is characterized predominantly by an anti-histone and anti-denatured DNA immune response^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00000464	Arrhythmia Ca... more >>rdiovascular Diseases Heart Arrest Heart Diseases Myocardial Infarction Ventricular Fibrillation Collapse <<	Phase 3	Completed	-	-
NCT00000556	Arrhythmia At... more >>rial Fibrillation Cardiovascular Diseases Heart Diseases Collapse <<	Phase 3	Completed	-	-
NCT00589303	Atrial Fibrillation ... more >> Heart Failure Collapse <<	Phase 3	Terminated(Lack of funding)	-	United States, Arizona ... more >> Mayo Clinic Arizona Scottsdale, Arizona, United States, 85259 United States, Indiana The Heart Group Evansville, Indiana, United States, 47710 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, Oregon Oregon Health and Science University Portland, Oregon, United States, 97239 United States, Tennessee Chattanooga Heart Institute Chattanooga, Tennessee, United States, 37404 Canada, Alberta University of Calgary and Calgary Health Region Calgary, Alberta, Canada, T2N-4N1 Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.6794 mL
- 18.3968 mL
- 36.7936 mL
- 5 mM
- 0.7359 mL
- 3.6794 mL
- 7.3587 mL
- 10 mM
- 0.3679 mL
- 1.8397 mL
- 3.6794 mL

技术信息

CAS号

614-39-1

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C13H22ClN3O

运输

蓝冰

分子量

271.79

别名

Procainamide Hydrochloride;Procainamide Hcl;Pronestyl;Procanbid;Procapan;Procaine Amide;Procamide;Procan;Procan SR;盐酸普鲁卡因胺

溶解度

DMSO	205.0 mg/mL (754.3 mM)
Water	350.0 mg/mL (1287.8 mM)

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00000464	Arrhythmia Ca... more >>rdiovascular Diseases Heart Arrest Heart Diseases Myocardial Infarction Ventricular Fibrillation Collapse <<	Phase 3	Completed	-	-
NCT00000556	Arrhythmia At... more >>rial Fibrillation Cardiovascular Diseases Heart Diseases Collapse <<	Phase 3	Completed	-	-
NCT00589303	Atrial Fibrillation ... more >> Heart Failure Collapse <<	Phase 3	Terminated(Lack of funding)	-	United States, Arizona ... more >> Mayo Clinic Arizona Scottsdale, Arizona, United States, 85259 United States, Indiana The Heart Group Evansville, Indiana, United States, 47710 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, Oregon Oregon Health and Science University Portland, Oregon, United States, 97239 United States, Tennessee Chattanooga Heart Institute Chattanooga, Tennessee, United States, 37404 Canada, Alberta University of Calgary and Calgary Health Region Calgary, Alberta, Canada, T2N-4N1 Collapse <<
NCT00000518	Arrhythmia Ca... more >>rdiovascular Diseases Death, Sudden, Cardiac Heart Diseases Tachycardia, Ventricular Ventricular Arrhythmia Ventricular Fibrillation Collapse <<	Phase 3	Completed	-	-
NCT00589303	-	-	Terminated(Lack of funding)	-	-
NCT02302274	Brugada Syndrome ... more >> Arrhythmogenic Right Ventricular Cardiomyopathy Collapse <<	Phase 1 Phase 2	Completed	-	United States, New York ... more >> New york University, School of Medicine New York, New York, United States, 10010 Collapse <<
NCT02739932	-	-	Active, not recruiting	August 2019	Canada, Alberta ... more >> Mathison Centre for Research and Education, University of Calgary Calgary, Alberta, Canada, T2N4Z6 Canada, Ontario Sunnybrook Health Sciences Centre Toronto, Ontario, Canada, M4N 3M5 Collapse <<
NCT01891058	Atrial Fibrillation ... more >> Atrial Flutter Collapse <<	Not Applicable	Recruiting	December 2018	Canada, Alberta ... more >> Foothills Medical Centre Recruiting Calgary, Alberta, Canada, 2TN 1M7 Contact: Andrew McRae, MD 403-944-5484 amcrae@ucalgary.ca Principal Investigator: Eddy Lang, MD Principal Investigator: Andrew McRae, MD Rockyview General Hospital Not yet recruiting Calgary, Alberta, Canada Contact: Andrew McRae, MD amcrae@ucalgary.ca University of Alberta Hospital Recruiting Edmonton, Alberta, Canada, T6G 2B7 Contact: Brian Rowe, MD (780) 407-6707 Brian.Rowe@ualberta.ca Principal Investigator: Brian Rowe, MD Canada, British Columbia Vancouver General Hospital Recruiting Vancouver, British Columbia, Canada, V5Z 1M9 Contact: Corinne Hohl, MD chohl@mail.ubc.ca Principal Investigator: Corinne Hohl, MD Canada, Ontario Kingston General Hospital Recruiting Kingston, Ontario, Canada, K7L 2V7 Contact: Robert Brison, MD 613-549-6666 ext 4217 brisonr@kgh.kari.net Principal Investigator: Robert Brison, MD Principal Investigator: Marco LA Sivilotti, MD Ottawa Hospital Research Institute Recruiting Ottawa, Ontario, Canada, K1Y 4E9 Principal Investigator: Ian Stiell, MD, MSc Mount Sinai Hospital Recruiting Toronto, Ontario, Canada, M5G 1X5 Contact: Shelley McLeod, MSc 416-586-4800 ext 8330 SMcLeod@mtsinai.on.ca Principal Investigator: Bjug Borgundvaag, MD Canada, Quebec Montreal Heart Institute Recruiting Montreal, Quebec, Canada, H1T 1C8 Contact: Alain Vadeboncoeur, MD alain.vadeboncoeur@gmail.com Principal Investigator: Alain Vadeboncoeur, MD Principal Investigator: Laurent Macle, MD Hopital Du Sacre-Coeur Recruiting Montreal, Quebec, Canada Contact: Judy Morris, MD Hopital de L'Enfant-Jesus Recruiting Quebec City, Quebec, Canada Contact: Eric Mercier, MD Contact: Marcel Emond, MD marcelemond1@me.com Collapse <<
NCT00383799	Ventricular Tachycardia ... more >> Wide QRS Tachycardia Collapse <<	Phase 4	Terminated(Steering Committee ... more >>decision after inclusion of 74 patients after 6 years and very slow inclusion rate) Collapse <<	-	Spain ... more >> Hospital El Escorial El Escorial, Madrid, Spain Hospital Universitario de Getafe Getafe, Madrid, Spain Hospital Santa María del Rosell Cartagena, Murcia, Spain Fundación Hospitalaria de Cieza Cieza, Murcia, Spain Hospital Los Arcos San Javier, Murcia, Spain Hospital General Alicante, Spain Hospital Clinic Barcelona, Spain Hospital Vall d'Hebron Barcelona, Spain Hospital de Basurto Bilbao, Spain Hospital San Cecilio Granada, Spain Hospital Virgen de las Nieves Granada, Spain Hospital General Universitario Gregorio Marañón Madrid, Spain, 28007 Hospital 12 de Octubre Madrid, Spain Hospital Clínico San Carlos Madrid, Spain Hospital de La Princesa Madrid, Spain Hospital de Móstoles Madrid, Spain Hospital General Universitario La Paz Madrid, Spain Hospital Puerta de Hierro Madrid, Spain Hospital Carlos Haya Malaga, Spain Hospital Virgen de la Arrixaca Murcia, Spain Hospital Clínico Virgen de la Victoria Málaga, Spain Hospital de Son Dureta Palma de Mallorca, Spain Hospital de Son Llatzer Palma de Mallorca, Spain Hospital de Donostia San Sebastián, Spain Hospital de Valme Sevilla, Spain Hospital Universitario Virgen del Rocío Sevilla, Spain Hospital Virgen de la Salud Toledo, Spain Hopital Clínico Universitario Valencia, Spain Hospital Río Hortega Valladolid, Spain Collapse <<
NCT03528616	-	-	Not yet recruiting	November 30, 2019	-
NCT00702117	Atrial Fibrillation ... more >> Tachycardia, Ventricular Brugada Syndrome Collapse <<	Phase 4	Completed	-	Spain ... more >> Hospital Donostia Donostia, Guipuzcoa, Spain Servicio de Cardiología, Hospital Clínic Barcelona, Spain, 08036 Hospital Puerta de Hierro Madrid, Spain Hospital La Fe Valencia, Spain Collapse <<
NCT02103088	Prostate Cancer	Not Applicable	Active, not recruiting	March 2019	Denmark ... more >> Department of Urology, Rigshospitalet Copenhagen, Copenhagen Ø, Denmark, 2100 Collapse <<
NCT01205529	Atrial Fibrillation	Not Applicable	Completed	-	United States, Tennessee ... more >> Vanderbilt University Medical Center Nashville, Tennessee, United States, 37232 Collapse <<
NCT01994070	Atrial Fibrillation	Phase 3	Completed	-	Canada, British Columbia ... more >> St Paul's Hospital Vancouver, British Columbia, Canada, V6Z 1Y6 Collapse <<
NCT01205529	-	-	Completed	-	-
NCT02114528	Ventricular Tachycardia ... more >> Ventricular Arrhythmia Collapse <<	Phase 4	Terminated(Low recruitment. Pi... more >>lot trial.) Collapse <<	-	Canada, Ontario ... more >> University of Ottawa Heart Institute Ottawa, Ontario, Canada, K1Y 4W7 Collapse <<
NCT02575534	Arrhythmias	Not Applicable	Withdrawn(No enrollment in stu... more >>dy.) Collapse <<	-	United States, Pennsylvania ... more >> Evan Adelstein Pittsburgh, Pennsylvania, United States, 15213 Collapse <<
NCT00000464	Arrhythmia Ca... more >>rdiovascular Diseases Heart Arrest Heart Diseases Myocardial Infarction Ventricular Fibrillation Collapse <<	Phase 3	Completed	-	-
NCT00000556	Arrhythmia At... more >>rial Fibrillation Cardiovascular Diseases Heart Diseases Collapse <<	Phase 3	Completed	-	-
NCT00589303	Atrial Fibrillation ... more >> Heart Failure Collapse <<	Phase 3	Terminated(Lack of funding)	-	United States, Arizona ... more >> Mayo Clinic Arizona Scottsdale, Arizona, United States, 85259 United States, Indiana The Heart Group Evansville, Indiana, United States, 47710 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, Oregon Oregon Health and Science University Portland, Oregon, United States, 97239 United States, Tennessee Chattanooga Heart Institute Chattanooga, Tennessee, United States, 37404 Canada, Alberta University of Calgary and Calgary Health Region Calgary, Alberta, Canada, T2N-4N1 Collapse <<
NCT00000518	Arrhythmia Ca... more >>rdiovascular Diseases Death, Sudden, Cardiac Heart Diseases Tachycardia, Ventricular Ventricular Arrhythmia Ventricular Fibrillation Collapse <<	Phase 3	Completed	-	-
NCT00589303	-	-	Terminated(Lack of funding)	-	-
NCT03528616	-	-	Not yet recruiting	November 30, 2019	-
NCT01891058	Atrial Fibrillation ... more >> Atrial Flutter Collapse <<	Not Applicable	Recruiting	December 2018	Canada, Alberta ... more >> Foothills Medical Centre Recruiting Calgary, Alberta, Canada, 2TN 1M7 Contact: Andrew McRae, MD 403-944-5484 amcrae@ucalgary.ca Principal Investigator: Eddy Lang, MD Principal Investigator: Andrew McRae, MD Rockyview General Hospital Not yet recruiting Calgary, Alberta, Canada Contact: Andrew McRae, MD amcrae@ucalgary.ca University of Alberta Hospital Recruiting Edmonton, Alberta, Canada, T6G 2B7 Contact: Brian Rowe, MD (780) 407-6707 Brian.Rowe@ualberta.ca Principal Investigator: Brian Rowe, MD Canada, British Columbia Vancouver General Hospital Recruiting Vancouver, British Columbia, Canada, V5Z 1M9 Contact: Corinne Hohl, MD chohl@mail.ubc.ca Principal Investigator: Corinne Hohl, MD Canada, Ontario Kingston General Hospital Recruiting Kingston, Ontario, Canada, K7L 2V7 Contact: Robert Brison, MD 613-549-6666 ext 4217 brisonr@kgh.kari.net Principal Investigator: Robert Brison, MD Principal Investigator: Marco LA Sivilotti, MD Ottawa Hospital Research Institute Recruiting Ottawa, Ontario, Canada, K1Y 4E9 Principal Investigator: Ian Stiell, MD, MSc Mount Sinai Hospital Recruiting Toronto, Ontario, Canada, M5G 1X5 Contact: Shelley McLeod, MSc 416-586-4800 ext 8330 SMcLeod@mtsinai.on.ca Principal Investigator: Bjug Borgundvaag, MD Canada, Quebec Montreal Heart Institute Recruiting Montreal, Quebec, Canada, H1T 1C8 Contact: Alain Vadeboncoeur, MD alain.vadeboncoeur@gmail.com Principal Investigator: Alain Vadeboncoeur, MD Principal Investigator: Laurent Macle, MD Hopital Du Sacre-Coeur Recruiting Montreal, Quebec, Canada Contact: Judy Morris, MD Hopital de L'Enfant-Jesus Recruiting Quebec City, Quebec, Canada Contact: Eric Mercier, MD Contact: Marcel Emond, MD marcelemond1@me.com Collapse <<
NCT02302274	Brugada Syndrome ... more >> Arrhythmogenic Right Ventricular Cardiomyopathy Collapse <<	Phase 1 Phase 2	Completed	-	United States, New York ... more >> New york University, School of Medicine New York, New York, United States, 10010 Collapse <<
NCT01994070	Atrial Fibrillation	Phase 3	Completed	-	Canada, British Columbia ... more >> St Paul's Hospital Vancouver, British Columbia, Canada, V6Z 1Y6 Collapse <<
NCT02114528	Ventricular Tachycardia ... more >> Ventricular Arrhythmia Collapse <<	Phase 4	Terminated(Low recruitment. Pi... more >>lot trial.) Collapse <<	-	Canada, Ontario ... more >> University of Ottawa Heart Institute Ottawa, Ontario, Canada, K1Y 4W7 Collapse <<
NCT02739932	-	-	Active, not recruiting	August 2019	Canada, Alberta ... more >> Mathison Centre for Research and Education, University of Calgary Calgary, Alberta, Canada, T2N4Z6 Canada, Ontario Sunnybrook Health Sciences Centre Toronto, Ontario, Canada, M4N 3M5 Collapse <<
NCT00383799	Ventricular Tachycardia ... more >> Wide QRS Tachycardia Collapse <<	Phase 4	Terminated(Steering Committee ... more >>decision after inclusion of 74 patients after 6 years and very slow inclusion rate) Collapse <<	-	Spain ... more >> Hospital El Escorial El Escorial, Madrid, Spain Hospital Universitario de Getafe Getafe, Madrid, Spain Hospital Santa María del Rosell Cartagena, Murcia, Spain Fundación Hospitalaria de Cieza Cieza, Murcia, Spain Hospital Los Arcos San Javier, Murcia, Spain Hospital General Alicante, Spain Hospital Clinic Barcelona, Spain Hospital Vall d'Hebron Barcelona, Spain Hospital de Basurto Bilbao, Spain Hospital San Cecilio Granada, Spain Hospital Virgen de las Nieves Granada, Spain Hospital General Universitario Gregorio Marañón Madrid, Spain, 28007 Hospital 12 de Octubre Madrid, Spain Hospital Clínico San Carlos Madrid, Spain Hospital de La Princesa Madrid, Spain Hospital de Móstoles Madrid, Spain Hospital General Universitario La Paz Madrid, Spain Hospital Puerta de Hierro Madrid, Spain Hospital Carlos Haya Malaga, Spain Hospital Virgen de la Arrixaca Murcia, Spain Hospital Clínico Virgen de la Victoria Málaga, Spain Hospital de Son Dureta Palma de Mallorca, Spain Hospital de Son Llatzer Palma de Mallorca, Spain Hospital de Donostia San Sebastián, Spain Hospital de Valme Sevilla, Spain Hospital Universitario Virgen del Rocío Sevilla, Spain Hospital Virgen de la Salud Toledo, Spain Hopital Clínico Universitario Valencia, Spain Hospital Río Hortega Valladolid, Spain Collapse <<
NCT02575534	Arrhythmias	Not Applicable	Withdrawn(No enrollment in stu... more >>dy.) Collapse <<	-	United States, Pennsylvania ... more >> Evan Adelstein Pittsburgh, Pennsylvania, United States, 15213 Collapse <<
NCT01205529	Atrial Fibrillation	Not Applicable	Completed	-	United States, Tennessee ... more >> Vanderbilt University Medical Center Nashville, Tennessee, United States, 37232 Collapse <<
NCT01205529	-	-	Completed	-	-
NCT02103088	Prostate Cancer	Not Applicable	Active, not recruiting	March 2019	Denmark ... more >> Department of Urology, Rigshospitalet Copenhagen, Copenhagen Ø, Denmark, 2100 Collapse <<
NCT00702117	Atrial Fibrillation ... more >> Tachycardia, Ventricular Brugada Syndrome Collapse <<	Phase 4	Completed	-	Spain ... more >> Hospital Donostia Donostia, Guipuzcoa, Spain Servicio de Cardiología, Hospital Clínic Barcelona, Spain, 08036 Hospital Puerta de Hierro Madrid, Spain Hospital La Fe Valencia, Spain Collapse <<

盐酸普鲁卡因胺 Catalog No. CSN13879

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