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Inflammation/Immunology

货号 产品名 CAS号 信息
CSN12744 2-(3-Trifluoromethylanilino)benzoic Acid 530-78-9 Flufenamic Acid is a COX inhibitor and prevents formation of prostaglandins, binds to and reduce the activity of prostaglandin F synthase and activate TRPC6, it is a NSAID drug.
CSN12772 Acitretin 55079-83-9 Acitretin is an analog of retinoid that can activate α-secretase ADAM10 gene expression. It has been used in the treatment of severe psoriasis.
CSN12798 Resiquimod 144875-48-9 Resiquimod is an agonist of TLR7 and TLR8 with antiviral and antitumoral activities.
CSN12864 2-(2,6-Dichloroanilino)phenylacetic Acid 15307-86-5 Diclofenac is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.
CSN12893 4-Hydroxy-2-methyl-N-(5-methylthiazol-2-yl)-2H-benzo[e][1,2]thiazine-3-carboxamide 1,1-dioxide 71125-38-7 Meloxicam is a nonsteroidal anti-inflammatory agent with selectivity for COX2 (IC50 = 11.8 μM) over COX1 (IC50 = 143 μM) in in vitro assays. It shows potent anti-inflammatory, antipyretic, and analgesic effects with low gastrointestinal toxicity.
CSN12919 Talarozole 201410-53-9 Talarozole is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid for the treatment of psoriasis and acne.
CSN12921 (R)-Lansoprazole 138530-94-6 (R)-Lansoprazole, the dextrorotatory enantiomer of lansoprazole, can irreversibly inactivate the H+/K+-stimulated ATPase pump.
CSN12948 Firocoxib 189954-96-9 Firocoxib is a potent and selective COX2 inhibitor with IC50 of 0.13 μM.
CSN12956 Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate 79794-75-5 Loratadine is an inverse agonist of peripheral histamine H1-receptor with IC50 of > 32 μM.
CSN12997 Bardoxolone 218600-44-3 Bardoxolone is a nuclear regulator factor (Nrf-2) activator.
CSN13057 2-(4-(2-Hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one 1044870-39-4 RVX-208 is an inhibitor of BET bromodomain BD2 with IC50 of 0.510 μM.
CSN13074 5-Amino-2-hydroxybenzoic acid 89-57-6 5-Aminosalicylic Acid is a potent inhibitor of interleukin 1 β production used to treat inflammatory bowel disease.
CSN13134 Imiquimod 99011-02-6 Imiquimod is an agonist of toll-like receptor 7 with EC50 of 2.1 µM that has antiviral and antitumor activities. It is commonly used to treat warts and anal areas.
CSN13149 SKF-86002 72873-74-6 SKF-86002 is a potent inhibitor of p38 MAP kinase with IC50 of 0.5-1 μM and inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 μM).
CSN13152 Crisaborole 906673-24-3 AN-2728 is a topically administered, boron-containing, anti-inflammatory compound that inhibits PDE4 activity with an IC50 of 0.49 μM and thereby suppresses the release of TNFalpha, IL-12, IL-23 and other cytokines.
CSN13421 Mocravimod HCl 509088-69-1 KRP-203 is a selective Sphingosine-1-phosphate receptor agonist that has been shown to reduce peripheral lymphocyte infiltration and to prolong survival in rat transplant models.
CSN13487 (E)-3-Tosylacrylonitrile 19542-67-7 BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. It also inhibits components of the ubiquitin system through inactivating the E2-conjugating enzymes Ubc (ubiquitin conjugating) 13 and UbcH7 and the E3 ligase LUBAC (linear ubiquitin assembly complex).
CSN12906 1,2-Dihydroxy-9,10-anthracenedione 72-48-0 Alizarin strongly inhibits P450 isoform CYP1A1, CYP1A2 and CYP1B1 with IC50 of 6.2/10.0 and 2.7 μM respectively, weakly inhibits CYP2A6 and CYP2E1, and does not inhibit CYP2C19, CYP3A4 and CYP3A5.
CSN12995 Cetirizine 2HCl 83881-52-1 Cetirizine 2HCl, a metabolite of hydroxyzine, is racemic selective and inverse agonist of H1 receptor used in the treatment of allergies and hay fever.
CSN13432 TPCA-1 507475-17-4 TPCA-1 is a selective and potent IKK-β inhibitor with IC50 value of 17.9 nM.
CSN12718 PHA 408 503555-55-3 PHA-408 is a potent, highly selective and ATP-competitive IKB kinase-2 (IKK-2) inhibitor (IC50: 40 nM).
CSN12801 PF-3845 1196109-52-0 PF-3845 is a potent, selective and irreversible FAAH inhibitor with Ki of 230 nM, showing negligible activity against FAAH2.
CSN12719 Tarenflurbil 51543-40-9 (R)-Flurbiprofen is the R-enantiomer of the racemate NSAID flurbiprofen, inhibiting the binding of [3H]9-cis-RA to RXRαLBD with IC50 of 75 μM.
CSN12897 SB 239063 193551-21-2 SB 239063 is a potent, selective and oral active p38 MAPK inhibitor with IC50 of 44 nM for recombinant purified p38α.
CSN12756 Indomethacin 53-86-1 Indomethacin is a nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively, used to reduce fever, pain, stiffness, and swelling.
CSN13101 Chlorzoxazone 95-25-0 Chlorzoxazone, a potassium channel activator, is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It is also a CYP2E1 inhibitor with IC50 value of 1.03μM.
CSN12821 UK-78282 hydrochloride 136647-02-4 UK-78282 is a blocker of the KV1.3 and KV1.4 voltage-gated potassium channels in T lymphocytes (IC50 values are 0.28 and 0.17 μM respectively) which suppresses T lymphocyte mitogenesis and leads to membrane depolarization and also blocks KV1.4 expressed in heart and brain.
CSN13105 MLN120B 783348-36-7 MLN120B is a potent and effective IKKbeta inhibitor.
CSN13135 Levodropropizine 99291-25-5 Levodropropizine is a histamine receptor inhibitor, and is an effective and very well tolerated peripheral antitussive drug.
CSN13086 Roxatidine Acetate HCl 93793-83-0 Roxatidine acetate HCl is a slective antagonist of histamin H2 receptor.
CSN13463 PH-797804 586379-66-0 PH-797804 is a pyridinone inhibitor of p38α with IC50 of 26 nM, being 4-fold selective versus p38β and does not inhibit JNK2.
CSN12944 U-73122 112648-68-7 U-73122 is an inhibitor of phospholipase C, phospholipase A2, and 5-LO(5-lipoxygenase).
CSN13160 Zaurategrast 455264-31-0 Zaurategrast is an oral α4-integrin inhibitor.
CSN12741 Phenylmethanesulfonyl fluoride 329-98-6 PMSF is a non-selective serine/cysteine protease inhibitor, also blocks anandamide metabolism.
CSN13420 Oglemilast 778576-62-8 Oglemilast is a potent PDE4 inhibitor, under clinical studies in the treatment of allergen-induced asthma.
CSN12789 Tacrolimus monohydrate 109581-93-3 Tacrolimus is a potent immunosuppressive drug often administered to transplant recipient patients and exhibits a variety of adverse cardiovascular effects. Its mechanism of action involves the formation of a high affinity complex (Ki = 0.2 nM) with FK-506 binding protein 12 (FKBP12).
CSN13499 (R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosphate 1092939-17-7 Ruxolitinib phosphate is a potent and selective JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, > 130-fold selectivity for JAK1/2 versus JAK3.
CSN13001 Irsogladine maleate 84504-69-8 Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.
CSN13150 CJ-42794 847728-01-2 CJ-42794 is a selective prostaglandin E receptor subtype 4 (EP4) antagonist, inhibits [3H]-PGE2 binding to the human EP4 receptor with a mean pKi of 8.5, a binding affinity that was at least 200-fold selective for the human EP4 receptor than other human EP receptor subtypes (EP1, EP2, and EP3).
CSN13161 Mavorixafor 558447-26-0 AMD-070 is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay, and inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs.
CSN13182 GTS-21 2HCl 156223-05-1 GTS-21 2HCl is a selective α7 nicotinic acetylcholine receptor agonist, has recently been established as a promising treatment for inflammation.
CSN13430 Timapiprant 851723-84-7 OC000459 is a potent and selective D prostanoid receptor 2 (DP2) antagonist with IC50 of 13 nM.
CSN13174 SCH 546738 906805-42-3 SCH 546738 is a potent and non-competitive small molecule CXCR3 antagonist with Ki of 0.4 nM .
CSN12829 Navarixin 473727-83-2 SCH-527123 is a potent antagonist of both CXCR1 and CXCR2 with IC50 of 42 nM and 3 nM, respectively.
CSN13433 TR-14035 232271-19-1 TR-14035 is a dual antagonist of both integrin α4β7 and integrin α4β1 with IC50 values of 7 nM and 87 nM, respectively, used as an anti-inflammatory agent.
CSN12827 Ponesimod 854107-55-4 Ponesimod is a selective S1P1 receptor modulator with EC50 of 5.7 nM, used in the reserch of treatment of multiple sclerosis (MS) and psoriasis.
CSN12845 RS 504393 300816-15-3 RS 504393 is a selective CCR2 chemokine receptor antagonist (IC50 values are 98 nM and > 100 μM for inhibition of human recombinant CCR2b and CCR1 receptors respectively).
CSN12891 Tunicamycin 11089-65-9 Tunicamycin is a mixture of homologous nucleoside antibiotics.
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