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CAS No.: 93793-83-0

Roxatidine Acetate HCl/盐酸罗沙替丁醋酸酯 Catalog No. CSN13086

Synonyms: HOE 760;Gastralgin;Roxatidine Acetate (hydrochloride)

Roxatidine acetate HCl is a slective antagonist of histamin H2 receptor.

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技术信息

生物活性

描述Roxatidine Acetate Hydrochloride is a specific and competitive H2-receptor antagonist. Roxatidine acetate and its main metabolite roxatidine inhibit histamine-induced gastric acid secretion in vitro with a potency greater than that of cimetidine, and in the range of that produced by ranitidine. In rats single or repeated dosing with roxatidine acetate did not influence drug metabolising enzymes in the liver nor did the drug show antiandrogenic activity in long term animal studies^[3]. Human pharmacology studies and short-term and long-term clinical trials have all shown that roxatidine acetate is an exceptionally well tolerated compound, without the antiandrogenic activity and interference with hepatic drug metabolism which have characterized cimetidine treatment^[4]. The pharmacodynamic and clinical data indicate that the efficacy of roxatidine acetate 75 mg twice-daily (b.i.d.) does not differ significantly from ranitidine 150 mg b.i.d. Roxatidine acetate is equally effective in the treatment of peptic disease including gastric ulcer, duodenal ulcer, and reflux esophagitis^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02555852	-	-	Completed	-	Canada, Quebec ... more >> Lady Davis Institute for Medical Research, Jewish General Hospital Montreal, Quebec, Canada, H3T1E2 Collapse <<
NCT02555852	-	-	Completed	-	Canada, Quebec ... more >> Lady Davis Institute for Medical Research, Jewish General Hospital Montreal, Quebec, Canada, H3T1E2 Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.5981 mL
- 12.9905 mL
- 25.9809 mL
- 5 mM
- 0.5196 mL
- 2.5981 mL
- 5.1962 mL
- 10 mM
- 0.2598 mL
- 1.2990 mL
- 2.5981 mL

技术信息

CAS号

93793-83-0

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C19H29ClN2O4

运输

蓝冰

分子量

384.90

别名

HOE 760;Gastralgin;Roxatidine Acetate (hydrochloride);TZU-0460;ROXATIDINE ACETATE HCl;Altat;Roxit; N-(3-(3-(N(1)-piperidinylmethyl)phenoxy)propyl)acetoxyacetamide;盐酸罗沙替丁醋酸酯;盐酸罗沙替丁

溶解度

DMSO	50.0 mg/mL (129.9 mM) warming
Water	80.0 mg/mL (207.8 mM)

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Roxatidine Acetate HCl/盐酸罗沙替丁醋酸酯 Catalog No. CSN13086

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