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CAS No.: 99291-25-5

Levodropropizine/左羟丙哌嗪 Catalog No. CSN13135

Synonyms: (S)-(-)-Dropropizine;DF-526;(–)-(S)-Dropropizine

Levodropropizine is a histamine receptor inhibitor, and is an effective and very well tolerated peripheral antitussive drug.

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生物活性

描述Levodropropizine, a common antitussive drug, suppresses seizure activity in rats with PTZ-induced (pentylenetetrazol) status epilepticus^[3]. Levodropropizine is commonly used as an antitussive drug for acute and chronic cough. It is a non-opioid agent with peripheral antitussive action via the modulation of sensory neuropeptide levels in the airways^[4]. Moreover, the antitussive drug has a peripheral site of action by injecting the drug intracerebroventricularly (i.c.v.). In these experiments levodropropizine (40 micrograms/50 microliters i.c.v.) did not prevent electrically-induced cough. And levodropropizine failed to prevent the vagally elicited cough in neuropeptide-depleted animals^[5]. Levodropropizine (10, 50 and 200 mg/kg) reduced in a dose-dependent manner the extravasation of Evans blue dye evoked by capsaicin. Levodropropizine inhibited also substance P-evoked extravasation, whereas it did not affect the extravasation evoked by platelet activating factor. Levodropropizine (10 and 100 microM) did not affect the contraction produced by [Sar9,Met(O2)11]substance P, a selective agonist for tachykinin NK1 receptors, in the rat urinary bladder in vitro^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01416480	Acute Bronchitis	Phase 3	Completed	-	Korea, Republic of ... more >> Hallym University Medical Center Anyang, Gyeonggi-do, Korea, Republic of, 431-070 Collapse <<
NCT01177852	Inflammation ... more >>Cough Rhinitis Collapse <<	Phase 3	Withdrawn	-	-
NCT03489837	Evaluate the Efficacy and Safe... more >>ty of Levotuss CR Tab. in Comparison With Levotuss Syrup in Patients With Cough Due to Acute or Chronic Bronchitis Collapse <<	Phase 3	Completed	-	Korea, Republic of ... more >> Included Seoul national hospital,10sites Seoul, Korea, Republic of Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.2317 mL
- 21.1586 mL
- 42.3173 mL
- 5 mM
- 0.8463 mL
- 4.2317 mL
- 8.4635 mL
- 10 mM
- 0.4232 mL
- 2.1159 mL
- 4.2317 mL

技术信息

CAS号

99291-25-5

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C13H20N2O2

运输

蓝冰

分子量

236.31

别名

(S)-(-)-Dropropizine;DF-526;(–)-(S)-Dropropizine;Levotuss;左羟丙哌嗪

溶解度

DMSO	47.0 mg/mL (198.9 mM)
Ethanol	47.0 mg/mL (198.9 mM)

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