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| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN16720 | 2-Amino-2-(4-octylphenethyl)propane-1,3-diol hydrochloride | 162359-56-0 | Fingolimod HCl is a S1P antagonist with IC50 of 0.033 nM. |
| CSN16710 | Diacerein | 13739-02-1 | Diacerein is a symptomatic slow-acting medicine in osteoarthritis which can reduce the level of IL-1 receptors leading to fewer receptors to form heterodimer complexes. |
| CSN17145 | Sotrastaurin | 425637-18-9 | Sotrastaurin is a potent and selective pan-PKC inhibitor, mostly for PKCθ with Ki of 0.22 nM and inactive to PKCζ. |
| CSN17197 | SB225002 | 182498-32-4 | SB225002 is a potent and selective non-peptide inhibitor of CXCR2 with IC50 of 22 nM, showing > 150-fold selectivity over CXCR1 and four other 7-TMRs. |
| CSN16720 | 2-Amino-2-(4-octylphenethyl)propane-1,3-diol hydrochloride | 162359-56-0 | Fingolimod HCl is a S1P antagonist with IC50 of 0.033 nM. |
| CSN16614 | (S)-7-(((2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-5-hydroxy-2-(4-hydroxyphenyl)chroman-4-one | 10236-47-2 | Naringin is a flavanone glycoside, which exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of cytochrome P450 enzymes. |
| CSN16629 | 2-Chloro-N-(4-(5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl)phenyl)acetamide | 1047953-91-2 | MI 2 MALT1 inhibitor is a small molecule and irreversible inhibitor of MALT1 with IC50 of 5.84 μM (suppression of proliferation in ABCDLBCL). |
| CSN16702 | Iguratimod | 123663-49-0 | Iguratimod is a selective inhibitor of COX2 (IC50 = 20 μM/7.7 μg/mL) and several inflammatory cytokines including interleukin-1 (IL-1), IL-6, IL-8 and tumour necrosis factor, it's an anti-inflammatory agent. |
| CSN16728 | Neflamapimod | 209410-46-8 | VX-745 is a potent and selective inhibitor of p38α with IC50 of 10 nM, 22-fold greater selectivity versus p38β and no inhibition to p38γ. |
| CSN16749 | 2-Hydroxy-N-(4-hydroxyphenyl)-benzamide | 526-18-1 | Osalmid can target ribonucleotide reductase small subunit M2 (RRM2) with IC50 of 8.23 μM. It is used for cholecystitis and bile duct inflammation. |
| CSN16782 | Ketorolac | 74103-06-3 | Ketorolac, a non-selective COX inhibitor with IC50s of 1.23 μM and 3.50 μM for COX1 and COX2, is a non-steroidal anti-inflammatory drug. |
| CSN16844 | (S)-2-(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid | 59-05-2 | Methotrexate, an antifolate compound, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH and can interfere with the growth of certain cells of the body, especially cells that reproduce quickly, such as cancer cells, bone marrow cells, and skin cells. |
| CSN16853 | 2-(6-Chloro-9H-carbazol-2-yl)propanoic acid | 53716-49-7 | Carprofen reduces inflammation by inhibition of COX-2 with IC50 of 30 nM, does not interfere with COX-1 activity. |
| CSN16903 | Lusutrombopag | 1110766-97-6 | Lusutrombopag is an agonist of bioavailablethrombopoietin (TPO) receptor that is used to treat chronic liver disease. |
| CSN16926 | N-(Pyridazin-3-yl)-4-(3-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzylidene)piperidine-1-carboxamide | 1020315-31-4 | PF-04457845 selectively inhibits FAAH with an IC50 of 7.2 nM. It has anti-inflammatory effects and is used as analgesic. |
| CSN17018 | (R)-(-)-Ibuprofen | 51146-57-7 | (R)-(-)-Ibuprofen, the less active enantiomer of ibuprofen, is an inhibitor of COX1 and 2 with IC50 of 13 and 370 μM respectively, it's a nonsteroidal anti-inflammatory. |
| CSN17031 | (S)-2-(4-Isobutylphenyl)propanoic acid | 51146-56-6 | (S)-(+)-Ibuprofen, the S-enantiomer of ibuprofen, is capable of inhibiting cyclooxygenase (COX) at clinically relevant concentrations, R(-)-ibuprofen is not a COX inhibitor. S(+)-Ibuprofen prevents neurodegeneration and cognitive decline in APPswe/PS1dE9 through multiple signaling pathways |
| CSN64503 | 1-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-2-methylpropan-1-one | 50847-11-5 | |
| CSN17117 | 2-(10-Oxo-10,11-dihydrodibenzo[b,f]thiepin-2-yl)propanoic acid | 74711-43-6 | Zaltoprofen is an inhibitor of COX with IC50s of 1.3 and 0.34 μM for COX-1 and COX-2, respectively, can be used for treatment of arthritis. |
| CSN64595 | 2-(10-Oxo-10,11-dihydrodibenzo[b,f]thiepin-2-yl)propanoic acid | 74711-43-6 | |
| CSN17121 | AMG-47a | 882663-88-9 | AMG-47a is a Lck inhibitor that can decrease T cell proliferation with anti-inflammatory activity. |
| CSN16655 | Sodium 2-((8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl phosphate | 2392-39-4 | Dexamethasone sodium phosphate is an agonist of glucocorticoid receptor. |
| CSN17063 | Hydroxyzine | 68-88-2 | Hydroxyzine is a histamine H1-receptor antagonist. |
| CSN16812 | Triflusal | 322-79-2 | Triflusal inhibits the production of thromboxane-B2 in platelets irreversibly by acetylating cycloxygenase-1. |
| CSN16696 | Ethyl 6-((4,4-dimethylthiochroman-6-yl)ethynyl)nicotinate | 118292-40-3 | Tazarotene selectively binds to retinoic acid receptors RAR-β and RAR-γ, it is the first receptor-selective aromatic retinoid that has effective treatment for psoriasis, hemorrhoids. |
| CSN16787 | Azelastine HCl | 79307-93-0 | Azelastine HCl is a selective antagonist of histamine receptor used in the treatment of rhinitis. |
| CSN16768 | Azelastine | 58581-89-8 | Azelastine is a potent, second-generation, selective, histamine antagonist. |
| CSN17084 | 5,5'-((2-Hydroxypropane-1,3-diyl)bis(oxy))bis(4-oxo-4H-chromene-2-carboxylic acid) | 16110-51-3 | Cromoglicic acid is used to treat the symptoms of asthma. |
| CSN16759 | JNJ-7777120 | 459168-41-3 | JNJ-7777120 is a selective antagonist of histamine-4 receptor (H4R) with Ki of 4 ± 1 nM. |
| CSN16893 | Secalciferol | 55721-11-4 | Secalciferol is a metabolite of Vitamin D, a possibly anti-inflammatory steroid which is involved in bone ossification. |
| CSN16764 | Irsogladine | 57381-26-7 | Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder. |
| CSN17008 | (S)-4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one | 85416-73-5 | (S)-(+)-Rolipram is a PDE4-inhibitor and an anti-inflammatory agent, less potent than its R-enantiomer. |
| CSN16615 | Norisoboldine | 23599-69-1 | Norisoboldine is an isoquinoline alkaloid isolated and purfied from the roots of Lindera aggregata, which acts as an AhR agonist, and enhances the function of the adenosine A1 receptor. |
| CSN16991 | Apilimod mesylate | 870087-36-8 | Apilimod mesylate is a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma, and can block filoviral entry and infection. It can also down-regulates both IL-12 p35 and IL-12/IL-23 p40 at the transcriptional level, and inhibits the production of both IL-12 and IL-23 cytokines. |
| CSN16637 | Tectoridin | 611-40-5 | Tectoridin, an isoflavone, is a natural product isolated and purified from the rhizomes of belamcanda chinensis (L.) DC. with anti-inflammatory activities. |
| CSN17204 | Itacitinib | 1334298-90-6 | Itacitinib is an oral selective JAK1 tyrosine kinase inhibitor, which is potential for the treatment of rheumatoid arthritis, myelofibrosis, rheumatoid arthritis and plaque psoriasis. |
| CSN16883 | Setipiprant | 866460-33-5 | Setipiprant is an orally available, selective CRTH2 antagonist. |
| CSN17196 | AH 6809 | 33458-93-4 | AH 6809 is an EP and DP receptor antagonist with nearly equal affinity for the cloned human EP1, EP2, EP3-III, and DP1 receptors. |
| CSN16839 | (-)-Indolactam V | 90365-57-4 | (-)-Indolactam V is a protein kinase C activator, which strongly directs human ES cell-derived definitive endoderm into pancreatic endoderm. |
| CSN16657 | Bay 65-1942 (R form) | 758683-21-5 | Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase. |
| CSN16863 | ADU-S100 | 1638241-89-0 | ML RR-S2 CDA is a highly active cyclic-di-nucleotide immune stimulators that activate DCs via the cytoplamtic receptor STING (Stimulator of Interferon Genes). |
| CSN16628 | Bay 65-1942 HCl | 600734-06-3 | Bay 65-1942 HCl is an ATP-competitive inhibitor that selectively targets IKKβ kinase. |
| CSN16655 | Sodium 2-((8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl phosphate | 2392-39-4 | Dexamethasone sodium phosphate is an agonist of glucocorticoid receptor. |
| CSN17172 | Skepinone-L | 1221485-83-1 | Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor. |
| CSN16871 | Peficitinib | 944118-01-8 | Peficitinb is an oral Janus kinase (JAK) inhibitor. Peficitinib inhibits JAK1, JAK2, JAK3 and Tyk2 enzyme activities with IC50s of 3.9, 5.0, 0.71 and 4.8 nM, respectively, and has moderate selectivity for JAK3 inhibition. |
| CSN16685 | Lansoprazole | 103577-45-3 | Lansoprazole is an inhibitor of proton-pump. It can reduce the gastric acid production of stomach. |
| CSN16703 | Nadifloxacin | 124858-35-1 | Nadifloxacin is a fluoroquinolone broad-spectrum antibacterial, working by inhibiting the enzyme DNA gyrase and thus inhibiting the bacterial multiplication. |
