优势价格
快速发货
品质保证
技术支持
400-920-2911 sales@csnpharm.cn
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN13625 | BAY 11-7085 | 196309-76-9 | BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM. |
| CSN13692 | 2-(3-(4-(3H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile | 1187594-09-7 | Baricitinib can selectively inhibit JAK1/2 inhibitor with IC50 values of 5.9 nM and 5.7 nM. |
| CSN13699 | Teriflunomide | 163451-81-8 | Teriflunomide, the active metabolite of an approved antirheumatic drug leflunomide, is an emerging oral therapy for multiple sclerosis (MS). It reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines. |
| CSN13766 | AM966 | 1228690-19-4 | AM966 is a high affinity, selective, oral LPA1 (lysophosphatidic acid receptor, IC50=17 nM) antagonist, with selectivity for this receptor over the other LPA receptors. |
| CSN13805 | Parecoxib | 198470-84-7 | Parecoxib is a potent and selective COX2 inhibitor. |
| CSN13806 | 5-Methyl-1-phenylpyridin-2(1H)-one | 53179-13-8 | Pirfenidone is an inhibitor for TGF-β production and TGF-β stimulated collagen production, reduces production of TNF-α and IL-1β, and also has anti-fibrotic and anti-inflammatory properties. |
| CSN13867 | Mometasone furoate | 83919-23-7 | Mometasone furoate is a prodrug of mometasone with high affinity for glucocorticoid receptor. |
| CSN13885 | N-(4-Ethoxyphenyl)acetamide | 62-44-2 | Phenacetin is a non-opioid analgesic used in treatment of pain-relieving and fever-reducing. |
| CSN14103 | Kaurenoic acid | 6730-83-2 | Kaurenoic Acid is a natural product isolated and purified from the herbs of Croton antisyphiliticus with anti-inflammatory property, the mechanisms may through inhibition of iNOS and COX-2 expression. Kaurenoic acid is an inducer of apoptosis, which is part of the innate mechanism of cell defense against neoplasia. Kaurenoic acid from A. continentalis may be a useful agent for inhibiting the cariogenic properties of S. mutans. |
| CSN15684 | (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone | 104987-11-3 | Tacrolimus is a potent immunosuppressive drug often administered to transplant recipient patients and exhibits a variety of adverse cardiovascular effects. Its mechanism of action involves the formation of a high affinity complex (Ki = 0.2 nM) with FK-506 binding protein 12 (FKBP12). |
| CSN15694 | N-(5-(4-((1,1-Dioxidothiomorpholino)methyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide | 1206161-97-8 | Filgotinib is a selective JAK1/2 inhibitor with IC50 values of 10/28nM, with less potency against JAK3 and TYK2 with IC50 values of 810 nM and 116 nM, respectively. |
| CSN15697 | Solcitinib | 1206163-45-2 | Solcitinib is a highly selective JAK1 inhibitor with IC50 value of 9.8 nM, with much less potency against JAK1 and JAK2 with IC50 values >100nM. |
| CSN15717 | PRT062607 | 1370261-96-3 | PRT062607 is a highly specific and potent inhibitor of Syk with IC50 of 1-2 nM with > 80-fold selectivity for Syk than Fgr, Lyn, FAK, Pyk2 and Zap70. |
| CSN15772 | TCS JNK 5a | 312917-14-9 | JNK Inhibitor IX can selectively inhibit JNK2 and JNK3 through targeting the ATP binding site with pIC50 of 6.5 and 6.7, respectively. |
| CSN15837 | VX-765 | 273404-37-8 | VX-765 is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM in a cell-free assay. |
| CSN13882 | LDC1267 | 1361030-48-9 | LDC1267 is a selective inhibitor of TAM and inhibits Tyro3, Axl and Mer with IC50 of < 5 nM, 8 nM, 29 nM, respectively. |
| CSN13915 | Ipratropium bromide hydrate | 66985-17-9 | Ipratropium bromide is a medication which opens up the medium and large airways in the lungs. |
| CSN13740 | (S)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione | 608141-41-9 | Apremilast is a small molecule inhibitor of PDE4 with an IC50 value of 74 nM. |
| CSN13506 | MK-571 sodium | 115103-85-0 | MK-571 Sodium is a competitive, potent and selective LTD4 antagonist with Ki values of 0.22 nM. |
| CSN13815 | CGI-1746 | 910232-84-7 | CGI-1746 is a Bruton's tyrosine kinase (Btk) inhibitor. |
| CSN13797 | RS102895 HCl | 1173022-16-6 | RS102895 HCl is a potent and specific CCR2 antagonist with binding IC50 of 360 nM, no significant inhibition on CCR1 (IC50 > 17 μM). |
| CSN13851 | 1-(2-(Benzyloxy)ethyl)-4-(hydroxydiphenylmethyl)quinuclidin-1-ium bromide | 869113-09-7 | Umeclidinium bromide is a long-acting mAchR antagonist with Ki values ranging in 0.05 to 0.16 nM for the cloned human M1-M5 mAChRs. |
| CSN13843 | Decernotinib | 944842-54-0 | Decernotinib is a selective JAK3 inhibitor with Ki value of 2.5nM, with >4-fold selectivity over JAK1, JAK2, and TYK2 with Ki values of 11nM, 13nM and 13nM, respectively. |
| CSN15709 | BAY 41-2272 | 256376-24-6 | BAY 41-2272 is an activator of guanylate cyclases (sGC). |
| CSN13630 | Vesatolimod | 1228585-88-3 | GS-9620 is a selective agonist of Toll-like receptor 7 (TLR-7) in chimpanzees and has anti-HBV infection activity. |
| CSN13510 | VUF10166 | 155584-74-0 | VUF10166 is a potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower. |
| CSN13824 | AMD-070 hydrochloride | 880549-30-4 | AMD-070 HCl is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay and inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs. |
| CSN15042 | Adenanthin | 111917-59-0 | Adenanthin, a natural product isolated and purified from the herb of Rabdosia adenantha with antiinflammatory, antitumour, bacteriostatic, and antileukemic activities, is an NF-κB and nucleophilic cysteines inhibitor, and can serve as the development of Prx I– and Prx II–targeted therapeutic agents. |
| CSN13598 | AS1517499 | 919486-40-1 | AS-1517499 is a potent STAT6 inhibitor with IC50 of 21 nM. |
| CSN14110 | Vexibinol | 97938-30-2 | Sophoraflavanone G is a small-molecule inhibitor of STAT signaling by targeting upstream signals of STATs that may have therapeutic potential for cancers caused by persistently activated STAT proteins. |
| CSN14353 | Deoxypodophyllotoxin | 19186-35-7 | Deoxypodophyllotoxin, a natural microtube inhibitor isolated and purified from the roots of Dysosma versipellis (Hance) M.Cheng ex Ying, is cytotoxic agent, antineoplastic agent and potent antitumor agent and may be beneficial in regulating the immediate-type allergic reaction. |
| CSN13560 | PF-8380 | 1144035-53-9 | PF-8380 is a potent and specific autotaxin inhibitor with IC50 of 2.8 nM. |
| CSN13624 | 2-(2-(4-Benzhydrylpiperazin-1-yl)ethoxy)ethanol dihydrochloride | 13073-96-6 | Decloxizine 2HCl is a histamine 1 receptor antagonist. |
| CSN13817 | PD 169316 | 152121-53-4 | PD169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor (IC50 = 89 nM). |
| CSN14293 | Warangalone | 4449-55-2 | Warangalone is a powerful inhibitor of protein kinase A isolated and purfied from the stem bark of Erythrina addisoniae, shows marked effectiveness as an anti-inflammatory on the phospholipase A(2)-induced paw edema and on the 12-O-tetradecanoylphorbol 13-acetate-induced ear edema in mice, after systemic and local administration, respectively. |
| CSN13842 | Avatrombopag | 570406-98-3 | Avatrombopag is an orally-active thrombopoietin (TPO) receptor agonist with EC50 of 3.3 nM. |
| CSN13920 | NG25 | 1315355-93-1 | NG25, a TAK1 inhibitor, inhibiting the activation of IKK by TLR7 and TLR9 agonists and preventing the secretion of type 1 IFNs induced by these ligands in Gen2.2 cells. |
| CSN13970 | Engeletin | 572-31-6 | Engeletin, a natural product isolated and purified from the leaves of Engelhardtia roxburghiana Wall., may serve as a potential anti-inflammatory agent. Engeletin possesses potent inhibition of PGE2 release with IC50 values of 19.6 μg/mL. |
| CSN13799 | INCB 3284 dimesylate | 887401-93-6 | INCB 3284 is a potent, selective and orally bioavailable hCCR2 antagonist with IC50 of 3.7 nM. |
| CSN13664 | MK-0812 | 624733-88-6 | MK-0812 is a potent and selective CCR2 antagonist with low nM affinity for CCR2 on human monocytes. |
| CSN13939 | PF-4840154 | 1332708-14-1 | PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse, with EC50 of 97 nM and 23 nM for rTrpA1 and hTrpA1, respectively. |
| CSN13877 | PI-3065 | 955977-50-1 | PI-3065 is a selective p110δ inhibitor with IC50 of 15 nM, > 70-fold selectivity over other PI3K family members. |
| CSN13689 | GLPG0634 analog | 1206101-20-3 | GLPG0634 analog is a pan JAK inhibitor with IC50s of 50-200 nM for JAK1/JAK2/JAK3. |
| CSN15818 | Fostamatinib | 901119-35-5 | Fostamatinib, a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM. |
| CSN15792 | CID-2858522 | 758679-97-9 | CID-2858522 selectively inhibits the NF-κB pathway (IC50 < 0.1 μM for PMA-stimulated IL-8 production) induced by PKC, operating downstream of PKC but upstream of IKKbeta, without inhibiting other NF-kappaB activation pathways. |
| CSN15836 | CEP-33779 | 1257704-57-6 | CEP-33779 is a highly selective JAK2 inhibitor with IC50 value of 1.8 nM, with much less potency against JAK1 and TYK2 with >40- and >800-fold IC50 values. |
| CSN13573 | ACHP HCl | 406209-26-5 | ACHP HCl is a potent and selective IKK-2 inhibitor with IC50 of 8.5 nM. |
| CSN13574 | c-Fms-IN-3 | 885704-21-2 | c-FMS inhibitor is a c-Fms kinase inhibitor with a potential as anti-inflammatory agent and antirheumatic agent. |
