|衣霉素|CsnPharm

CAS No.: 11089-65-9

Tunicamycin/衣霉素 Catalog No. CSN12891

Synonyms: Tunicamycin Mixture;NSC-177382;衣霉素

Tunicamycin is a mixture of homologous nucleoside antibiotics.

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技术信息

生物活性

描述Tunicamycin, an N-glycosylation inhibitor, causes unfolded protein response and is widely used as pharmacological inducer of endoplasmic reticulum stress. Tunicamycin induces the resistance to topoisomerase inhibitors through GRP78 up-regulation and G1 arrest of the cell cycle^[3]. Activation of the UPR (unfolded protein response) response by tunicamycin (TM), an ER stress inducer, leads to accumulation of p27 and G1 cell cycle arrest in melanoma cells^[4]. Tunicamycin dramatically reduced ABCG2 (ATP-binding cassette subfamily G member 2) expression, altered its subcellular localization, and reversed its drug efflux effect in multiple hepatocellular carcinoma cell lines. Tunicamycin combined with cisplatin (CDDP) inhibited proliferating cell nuclear antigen (PCNA) expression and increased the cleavage of PARP; this effect was partially rescued by the overexpression of ABCG2 or Akt-myr^[5]. Tunicamycin significantly induced hepatic a yellowish color and ER stress, as well as increasing serum levels of aspartate transaminase and alanine transaminase. Besides, tunicamycin remarkably increased hepatic triglyceride content and suppressed the expression of apolipoprotein B100. In addition, tunicamycin-treated mice had lower serum levels of triglyceride, apolipoprotein B, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol. Tunicamycin alters hepatic energy homeostasis by increasing triglyceride accumulation and decreasing glycogen content^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01754441	-	-	Unknown	December 2017	United States, Delaware ... more >> Alfred I. duPont Hospital for Children Wilmington, Delaware, United States, 19803 United States, Florida Nemours Children's Specialty Care, Jacksonville Jacksonville, Florida, United States, 32207 Nemours Children's Hospital Orlando, Florida, United States, 32827 Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.2242 mL
- 6.1208 mL
- 12.2416 mL
- 5 mM
- 0.2448 mL
- 1.2242 mL
- 2.4483 mL
- 10 mM
- 0.1224 mL
- 0.6121 mL
- 1.2242 mL

技术信息

CAS号

11089-65-9

储存条件

粉末: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C37H60N4O16

运输

蓝冰

分子量

816.89

别名

Tunicamycin Mixture;NSC-177382;衣霉素

溶解度

DMSO	39.0 mg/mL (47.7 mM)

动物实验配方

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