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| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN19165 | (E)-1-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one hydrochloride | 521984-48-5 | SIS3 is an inhibitor of Smad3 and can inhibit TGF-β and activin signaling without affecting other pathways. |
| CSN19147 | LY 303511 HCl | 2070014-90-1 | LY303511 HCl is an analogue of LY294002 which can inhibit mTOR-dependent phosphorylation of S6K, but not PI3K-dependent phosphorylation of Akt. It also blocks voltage-gated potassium (Kv) channels with IC50 value of 64.6 μM. |
| CSN19151 | BFH772 | 890128-81-1 | BFH772 selectively targets VEGFR2 kinase with IC50 of 3 nM. |
| CSN19180 | CX-6258 HCl | 1353859-00-3 | CX-6258 HCl is a potent, orally efficacious pan-Pim kinase inhibitor with IC50 of 5 nM, 25 nM and 16 nM for Pim1, Pim2, and Pim3, respectively. |
| CSN19182 | Cilengitide TFA | 199807-35-7 | Cilengitide Trifluoroacetate is a cyclic RGD pentapeptide antagonist of integrins αvβ3, αvβ5 and α5β1. |
| CSN19198 | INH6 | 1001753-24-7 | INH6 can bind to Hec1 and inhibit its association with Nek2 and kinetochores. |
| CSN19201 | N-((1R,2S)-2-Phenylcyclopropyl)piperidin-4-amine dihydrochloride | 1821798-25-7 | GSK-LSD1 2HCl is a selective LSD1 inhibitor with IC50 of 16 nM. |
| CSN19204 | Cerdulatinib HCl | 1369761-01-2 | Cerdulatinib HCl is a dual JAK/SYK inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively. It also inhibits other kinases with IC50 less than 200 nM. |
| CSN19214 | Cyclo(-RGDfK) TFA | 500577-51-5 | Cyclo(-RGDfK) Trifluoroacetate is a highly potent and selective inhibitor for the αvβ3 integrin with a IC50 of 0.94 nM. |
| CSN19142 | CZ415 | 1429639-50-8 | CZ415 is a potent and highly selective ATP-competitive mTOR inhibitor with pKdapp value of 8.2. |
| CSN19162 | Ciliobrevin A | 302803-72-1 | Ciliobrevin A inhibits hedgehog (Hh) signaling pathway with IC50 less than 10 μM. |
| CSN19222 | Chetomin | 1403-36-7 | Chetomin is an inhibitor of HIF-1 by weaken transcription of HIF-1,disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations. |
| CSN19229 | Chaetocin | 28097-03-2 | Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU (VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively. It also inhibits thioredoxin reductase (TrxR) with an IC50 of 4 μM. |
| CSN19243 | 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile hydrochloride | 2095432-28-1 | CPI-455 HCl is an inhibitor of KDM5. It can elevate global levels of H3K4 trimethylation (H3K4me3) and decrease the number of DTPs in multiple cancer cell line models. |
| CSN19234 | PD0166285 | 185039-89-8 | PD0166285 inhibits Wee1 and Chk1 at nanomolar concentrations and can hinder G2 checkpoint. |
| CSN19153 | S49076 | 1265965-22-7 | S49076 is a potent inhibitor of MET, AXL/MER, and FGFRs. |
| CSN19228 | Sabutoclax | 1228108-65-3 | Sabutoclax is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively. |
| CSN19209 | PRT060318 Dihydrochloride | N/A | PRT060318 2HCl is a selective inhibitor of the Syk tyrosine kinase, as an approach to HIT treatment. |
| CSN19192 | PF-562271 HCl | 939791-41-0 | PF-562271 HCl is the HCl salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and > 100-fold selectivity against other protein kinases, except for some CDKs. |
| CSN19183 | SANT-1 | 304909-07-7 | SANT-1 can directly bind to Smoothened (Smo) receptor with Kd of 1.2 nM. It also exhibits inhibition of Smo agonist effects (IC50 = 20 nM). |
| CSN19149 | Laduviglusib 3HCl | 1782235-14-6 | CHIR-99021 3HCl is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM, showing > 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases. |
| CSN19148 | GSK2110183 analog 1 HCl | 2070009-64-0 | GSK2110183 HCl is an orally bioavailable, selective, ATP-competitive and potent pan-Akt inhibitor with IC50s of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively. |
| CSN19154 | Ibrutinib-biotin | 1599432-18-4 | Ibrutinib-biotin is a probe that consists of Ibrutinib linked to biotin via a long chain linker, with an IC50 of 0.755-1.02 nM for BTK. |
| CSN19143 | PQR620 | 1927857-56-4 | PRQ620 is a highly potent and selective mTORC1/2 inhibitor, shows anti-tumor effects in vitro and in vivo. |
| CSN19155 | Futibatinib | 1448169-71-8 | FGFR-IN-1 is a potent and highly selective FGFR inhibitor, used for antitumor treatment. |
| CSN19225 | N-(3-((5-Cyclopropyl-2-((2-methyl-1,2,3,4-tetrahydroisoquinolin-6-yl)amino)pyrimidin-4-yl)amino)propyl)cyclobutanecarboxamide hydrochloride(1:x) | 2599216-02-9 | MRT68921·xHCl is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively. |
| CSN19210 | SAG HCl | 2095432-58-7 | SAG HCl is a cell-permeable Smoothened (Smo) agonist with EC50 of 3 nM in Shh-LIGHT2 cells. |
| CSN19145 | A-674563 HCl | 2070009-66-2 | A-674563 HCl is a potent and selective Akt1 inhibitor with Ki of 11 nM. |
| CSN19156 | UNC2025 HCl | 2070015-17-5 | UNC2025 HCl is a potent and orally bioavailable Mer/Flt3 dual inhibitor with IC50 of 0.8/0.74 nM for Mer/Flt3. |
| CSN19164 | RU-SKI 43 HCl | 1782573-67-4 | RU-SKI 43 HCl is a small molecule inhibitor of Hhat (Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh. |
| CSN19157 | (Rac)-IBT6A hydrochloride | 1807619-60-8 | Btk inhibitor 1 HCl is a pyrazolo[3,4-d]pyrimidine derivative as a Btk kinase inhibitor. |
| CSN19141 | CAY10505 | 1218777-13-9 | CAY10505 is dehydroxyl of AS-252424, which is a PI3Kγ inhibitor with IC50 of 33 nM. |
| CSN19158 | CEP-28122 mesylate salt | 1431697-88-9 | CEP-28122 mesylate is a highly potent and selective orally active ALK inhibitor with IC50 of 1.9 ± 0.5 nM in an enzyme-based TRF assay. |
| CSN19211 | GSK2879552 2HCl | 1902123-72-1 | GSK2879552 2HCl is an orally available, irreversible, inhibitor of lysine specific demethylase 1 (LSD1), with potential antineoplastic activity. |
| CSN19176 | 6-((2-((4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile monohydrochloride | 1797989-42-4 | CHIR-99021 HCl is HCl of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM and shows greater than 500-fold selectivity for GSK-3 versus its closest homologs Cdc2 and ERK2. |
| CSN19216 | 2-((4,6-Dimethylpyrimidin-2-yl)thio)-N-(5-(naphthalen-1-ylmethyl)thiazol-2-yl)acetamide | 709002-46-0 | SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM. |
| CSN19159 | Fenebrutinib | 1434048-34-6 | GDC-0853 is a potent and orally BTK inhibitor. |
| CSN19188 | K-Ras(G12C) inhibitor 9 | 1469337-91-4 | K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras (G12C). |
| CSN19199 | TAI-1 | 1334921-03-7 | TAI-1 is a potent and specific Hec1 inhibitor, which disrupts Hec1-Nek2 protein interaction. |
| CSN19172 | Dovitinib dilactic acid | 852433-84-2 | Dovitinib dilactic acid is the dilactic acid of dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGFR1 and HER2. |
| CSN19190 | CH5138303 | 959763-06-5 | CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM. |
| CSN19202 | BV-6 Trifluoroacetate | N/A | BV-6 trifluoroacetate is a SMAC mimetic, dual cIAP and XIAP inhibitor. |
| CSN19221 | GSK2292767 | 1254036-66-2 | GSK2292767 is a potent and selective PI3Kδ inhibitor. |
| CSN19230 | Z-VAD-FMK | 161401-82-7 | Z-VAD-FMK is an irreversible pan-caspase inhibitor. |
| CSN19191 | ARQ 621 | 1095253-39-6 | ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. |
| CSN19241 | SRT 2183 | 1001908-89-9 | SRT2183 is a small-molecule activator of the sirtuin subtype SIRT1. |
| CSN19232 | RHPS4 | 390362-78-4 | RHPS4 is a potent inhibitor of Telomerase at submicromolar. |
| CSN19233 | MS049 2HCl | 2095432-59-8 | MS049 2HCl is a potent and selective inhibitor of PRMT4 and PRMT6 with IC50s of 34 nM and 43 nM, respectively. |
