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CAS No.: 2095432-58-7
Synonyms: Smoothened Agonist HCl;SAG;SAG (Smo agonist)
SAG HCl is a cell-permeable Smoothened (Smo) agonist with EC50 of 3 nM in Shh-LIGHT2 cells.
生物活性
动物研究 | |
剂量 | Mice: 15 mg/kg - 20 mg/kg[3] (i.p.) |
给药途径 | i.p. |
实验方案
技术信息
CAS号 | 2095432-58-7 | 储存条件 |
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分子式 | C28H29Cl2N3OS | 运输 | 蓝冰 | |||||
分子量 | 526.52 | 别名 | Smoothened Agonist HCl;SAG;SAG (Smo agonist) | |||||
溶解度 |
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动物实验配方 |
Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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HUVEC | - | Cytotoxicity assay | 24 h | Cytotoxicity against HUVEC after 24 hrs by WST-1 assay, IC50=22 μM | 22985958 |
mouse Shh-Light II cell | - | Function assay | 48 hrs | Activation of Shh pathway in mouse Shh-Light II cells assessed as induction of gli1 expression after 48 hrs by renilla luminescence assay, EC50=0.0088 μM | 22985958 |
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