CAS No.: 852433-84-2
Dovitinib dilactic acid Catalog No. CSN19172
Synonyms: TKI258 Dilactic Acid;Dovitinib Dilactic Acid;CHIR-258
Dovitinib dilactic acid is the dilactic acid of dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGFR1 and HER2.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Huynh H, Chow PK, et al. Dovitinib demonstrates antitumor and antimetastatic activities in xenograft models of hepatocellular carcinoma. J Hepatol. 2012 Mar;56(3):595-601.
- [2] Trudel S, Li ZH, et al. CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma. Blood. 2005 Apr 1;105(7):2941-8.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 852433-84-2 | 储存条件 |
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| 分子式 | C27H33FN6O7 | 运输 | 蓝冰 | |
| 分子量 | 572.59 | 别名 | TKI258 Dilactic Acid;Dovitinib Dilactic Acid;CHIR-258;TKI258 |
