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Cancer

货号 产品名 CAS号 信息
CSN19712 S63845 1799633-27-4 S63845 specifically binds with high affinity to the BH3-binding groove of MCL1. S63845 potently kills MCL1-dependent cancer cells, including multiple myeloma, leukaemia and lymphoma cells, by activating the BAX/BAK-dependent mitochondrial apoptotic pathway.
CSN19693 Iberdomide 1323403-33-3 CC-220 is a modulator of cereblon that is potential to treat systemic lupus erythematosis and multiple myeloma.
CSN19720 (2S)-N-(1-(2-Chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide 1448346-63-1 AG-120 Racemate is the racemate form of AG-120 with no activity.
CSN68780 1-Isothiocyanato-4-(methylsulfinyl)butane 4478-93-7
CSN19757 Roblitinib 1708971-55-4 FGF401, an inhibitor of human fibroblast growth factor receptor 4 (FGFR4, IC50 = 1.1 nM), has potential antineoplastic activity.
CSN19812 Idarubicin 58957-92-9 Idarubicin is a semisynthetic 4-demethoxy analogue of the antineoplastic anthracycline antibiotic daunorubicin.
CSN19706 Edicotinib 1142363-52-7 JNJ-40346527 is an orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R) with potential antineoplastic activity.
CSN19721 Tiamulin 55297-95-5 Tiamulin is an antibiotic, and it can inhibit breast cancer growth and pulmonary metastasis by decreasing the activity of Ecto-5'-nucleotidase (CD73).
CSN19726 4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile hydrochloride 102676-31-3 Fadrozole HCl specifically inhibits aromatase, blocking the aromatization of androstenedione and testosterone into estrone and estradiol, respectively.
CSN19732 NCL-1 2199214-20-3 NCL-1 is a KDM1A-specific inhibitor to promote differentiation and apoptosis of glioma stem cells (GSCs). KDM1A inhibitor modulates several pathways related to stemness, differentiation and apoptosis. it can induce activation of the unfolded protein response (UPR) pathway.
CSN19690 PHTPP 805239-56-9 PHTPP has selective antagonism of estrogen ERβ receptor .
CSN19805 PGMI-004A 1313738-90-7 PGMI-004A is a potent and selective PGAM1 inhibitor.
CSN19813 Aderbasib 791828-58-5 Aderbasib is a sheddase inhibitor, is also an orally bioavailable inhibitor of the ADAM (A disintegrin and metalloprotease) family of multifunctional membrane-bound proteins with potential antineoplastic activity.
CSN19819 NU-7200 842122-14-9 NU-7200 is a potent DNA-PK inhibitor with potential anticancer activity.
CSN19702 (R)-4-(2-(4-(1-(3-Methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl)phenoxy)ethyl)-1,3-dimethylpiperazin-2-one 1869912-39-9 AZD5153 exhibits excellent pharmacokinetic profile and high potency in vitro and in vivo effecting c-Myc downregulation and tumor growth inhibition in xenograft studies.
CSN19817 NU-7031 79105-88-7 NU-7031 is a potent DNA-PK inhibitor with potential anticancer activity.
CSN19818 NU-7199 69541-04-4 NU-7199 is a potent DNA-PK inhibitor with potential anticancer activity.
CSN19811 Heptaplatin 146665-77-2 Heptaplatin is a platinum derivative with anticancer activity against various cancer cell lines, including cisplatin-resistant cancer cell lines.
CSN19802 RKI-1313 1342276-76-9 RKI-1313 is a negative control for RKI-1447 (GLXC-05200) which is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer.
CSN19816 Actinonin 13434-13-4 Actinonin is a bioactive peptide and antibiotic that is a potent inhibitor of CD13 and aminopeptidase (leucine aminopeptidase).
CSN19763 Elacestrant 2HCl 1349723-93-8 Elacestrant 2HCl is an orally available, selective estrogen receptor degrader (SERD) and selective estrogen receptor modulator (SERM), with potential antineoplastic and estrogen-like activities.
CSN19762 Elacestrant 722533-56-4 Elacestrant is an orally available, selective estrogen receptor degrader (SERD) and selective estrogen receptor modulator (SERM), with potential antineoplastic and estrogen-like activities.
CSN19715 Rolapitant 552292-08-7 Rolapitant inhibits CYP2D6, breast cancer resistance protein (BCRP), and Neurokinin (NK)1 Receptor.
CSN19814 LEQ506 1204975-42-7 LEQ506 is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity.
CSN19698 Lerociclib 1628256-23-4 G1T38 is a potent, selective, and orally bioavailable CDK4/6 inhibitor with unique pharmacokinetic and pharmacodynamic properties, which result in high efficacy against CDK4/6 dependent tumors while minimizing the undesirable on-target bone marrow activity.
CSN19744 L-Sulforaphane 142825-10-3 (R)-Sulforaphane, a natural product isolated and purified from brocoli, is a promising potential chemopreventitive agent in bladder cancer.
CSN19745 Apicidin 183506-66-3 Apicidin is a potent histone deacetylase (HDAC) inhibitor with antiangiogenic and anti-invasive activity, which blocks proliferation of human stomach and breast cancer cells, and induces apoptosis and autophagy in human oral squamous carcinoma cells.
CSN19724 ALK Inhibitor C29 2093414-37-8 ALK inhibitor C29 shows promising anti-ALK activities in enzymatic- and cell-based assays, while in vivo H3122 xenograft model study showed that it effectively suppressed ALK-driven tumor growth.
CSN19736 Bis(N,N '-disalicylidene)-1,2-cyclohexanediamine-cobalt(II) 40784-65-4 MEK1 inhibitor CL2 exhibits MEK1 binding affinity with IC50 71 nM, which is so far the best result for metal complexes and more potent than U0126(7.02 μM) and AZD6244(2.20 μM).
CSN19728 Lss-11 1392014-36-6 LSS-11 bound to DNA in vitro and in cell mainly by minor groove binding and significantly increased the stability of DNA, which could be fundamental for the biological activities of LSS-11. It can inhibit multiple DNA-associated processes and tumor growth.
CSN19755 MBQ-167 2097938-73-1 MBQ-167 is a dual Rac and Cdc42 inhibitor, potential to be developed as an anticancer drug.
CSN19756 Cdc7 inhibitor 7c 1330781-04-8 CDC7 inhibitor C10C is a high selective CDC7 inhibitor.
CSN19758 Debio 0617B 1332329-27-7 Debio 0617B is a mutiple kinase inhitor and can inhibit the growth of STAT3-Driven solid tumors through combined inhibition of JAK, SRC, and class III/V receptor tyrosine kinases..
CSN19733 Ncd-38 1456907-39-3 NCD-38 is a KDM1A-specific inhibitor to promote differentiation and apoptosis of glioma stem cells (GSCs). KDM1A inhibitor modulates several pathways related to stemness, differentiation and apoptosis. it can induce activation of the unfolded protein response (UPR) pathway.
CSN19751 Nisc-6 2097636-49-0 NISC-6 is a napthalamide-isoselenocyanate compound which acts as a dual Topoisomerase-IIα and Akt pathway inhibitor.
CSN19694 Sb-fi-26 1541209-75-9 SB-FI-26, an antinociceptive agent which binds to anandamide transporters FABP5 and FABP7, suppresses the proliferation, migration, invasiveness and colony formation of PC3-M cells in vitro.
CSN19752 CD161 1627716-22-6 CD161 is a potent, selective, and orally active BET inhibitor.
CSN19711 CB-1158-analog 1345810-21-0 CB-1158 is a potent arginase inhibitor. CB-1158 has the potential for anti-tumor activity in renal cell cancer, breast cancer, non-small cell lung cancer, acute myeloid leukemia, and other tumor types where arginase-secreting MDSCs are known to play an immunosuppressive role.
CSN19701 Top-Tdp Tri Inhibitor C12 2092927-74-5 Top-Tdp tri inhibitor C12 is one of the first triple inhibitors of human topoisomerase 1, tyrosyl–DNA phohosphodiesterase 1 (Tdp1), and tyrosyl–DNA phosphodiesterase 2 (Tdp2).
CSN19705 ASP5878 1453208-66-6 ASP5878 is a selective FGFR inhibitor, to treat FGFR3-dependent urothelial cancer with or without chemoresistance.
CSN19692 Lt-626 1207456-03-8 LT-626 functions as an effective radiosensitizer during fractionated radiation treatment, leading to significant decrease in tumor burden and doubling the median survival.
CSN20998 Dehydropachymic acid 77012-31-8 Dehydropachymic acid is extracted from the root of wolfiporia cocos (Schw.) Ryv. with antiinflammatory activity.
CSN20998 Dehydropachymic acid 77012-31-8 Dehydropachymic acid is extracted from the root of wolfiporia cocos (Schw.) Ryv. with antiinflammatory activity.
CSN20998 Dehydropachymic acid 77012-31-8 Dehydropachymic acid is extracted from the root of wolfiporia cocos (Schw.) Ryv. with antiinflammatory activity.
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