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货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN19712 | S63845 | 1799633-27-4 | S63845 specifically binds with high affinity to the BH3-binding groove of MCL1. S63845 potently kills MCL1-dependent cancer cells, including multiple myeloma, leukaemia and lymphoma cells, by activating the BAX/BAK-dependent mitochondrial apoptotic pathway. |
CSN19693 | Iberdomide | 1323403-33-3 | CC-220 is a modulator of cereblon that is potential to treat systemic lupus erythematosis and multiple myeloma. |
CSN19720 | (2S)-N-(1-(2-Chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide | 1448346-63-1 | AG-120 Racemate is the racemate form of AG-120 with no activity. |
CSN68780 | 1-Isothiocyanato-4-(methylsulfinyl)butane | 4478-93-7 | |
CSN19757 | Roblitinib | 1708971-55-4 | FGF401, an inhibitor of human fibroblast growth factor receptor 4 (FGFR4, IC50 = 1.1 nM), has potential antineoplastic activity. |
CSN19812 | Idarubicin | 58957-92-9 | Idarubicin is a semisynthetic 4-demethoxy analogue of the antineoplastic anthracycline antibiotic daunorubicin. |
CSN19706 | Edicotinib | 1142363-52-7 | JNJ-40346527 is an orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R) with potential antineoplastic activity. |
CSN19721 | Tiamulin | 55297-95-5 | Tiamulin is an antibiotic, and it can inhibit breast cancer growth and pulmonary metastasis by decreasing the activity of Ecto-5'-nucleotidase (CD73). |
CSN19726 | 4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile hydrochloride | 102676-31-3 | Fadrozole HCl specifically inhibits aromatase, blocking the aromatization of androstenedione and testosterone into estrone and estradiol, respectively. |
CSN19732 | NCL-1 | 2199214-20-3 | NCL-1 is a KDM1A-specific inhibitor to promote differentiation and apoptosis of glioma stem cells (GSCs). KDM1A inhibitor modulates several pathways related to stemness, differentiation and apoptosis. it can induce activation of the unfolded protein response (UPR) pathway. |
CSN19690 | PHTPP | 805239-56-9 | PHTPP has selective antagonism of estrogen ERβ receptor . |
CSN19805 | PGMI-004A | 1313738-90-7 | PGMI-004A is a potent and selective PGAM1 inhibitor. |
CSN19813 | Aderbasib | 791828-58-5 | Aderbasib is a sheddase inhibitor, is also an orally bioavailable inhibitor of the ADAM (A disintegrin and metalloprotease) family of multifunctional membrane-bound proteins with potential antineoplastic activity. |
CSN19819 | NU-7200 | 842122-14-9 | NU-7200 is a potent DNA-PK inhibitor with potential anticancer activity. |
CSN19702 | (R)-4-(2-(4-(1-(3-Methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl)phenoxy)ethyl)-1,3-dimethylpiperazin-2-one | 1869912-39-9 | AZD5153 exhibits excellent pharmacokinetic profile and high potency in vitro and in vivo effecting c-Myc downregulation and tumor growth inhibition in xenograft studies. |
CSN19817 | NU-7031 | 79105-88-7 | NU-7031 is a potent DNA-PK inhibitor with potential anticancer activity. |
CSN19818 | NU-7199 | 69541-04-4 | NU-7199 is a potent DNA-PK inhibitor with potential anticancer activity. |
CSN19811 | Heptaplatin | 146665-77-2 | Heptaplatin is a platinum derivative with anticancer activity against various cancer cell lines, including cisplatin-resistant cancer cell lines. |
CSN19802 | RKI-1313 | 1342276-76-9 | RKI-1313 is a negative control for RKI-1447 (GLXC-05200) which is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer. |
CSN19816 | Actinonin | 13434-13-4 | Actinonin is a bioactive peptide and antibiotic that is a potent inhibitor of CD13 and aminopeptidase (leucine aminopeptidase). |
CSN19763 | Elacestrant 2HCl | 1349723-93-8 | Elacestrant 2HCl is an orally available, selective estrogen receptor degrader (SERD) and selective estrogen receptor modulator (SERM), with potential antineoplastic and estrogen-like activities. |
CSN19762 | Elacestrant | 722533-56-4 | Elacestrant is an orally available, selective estrogen receptor degrader (SERD) and selective estrogen receptor modulator (SERM), with potential antineoplastic and estrogen-like activities. |
CSN19715 | Rolapitant | 552292-08-7 | Rolapitant inhibits CYP2D6, breast cancer resistance protein (BCRP), and Neurokinin (NK)1 Receptor. |
CSN19814 | LEQ506 | 1204975-42-7 | LEQ506 is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. |
CSN19698 | Lerociclib | 1628256-23-4 | G1T38 is a potent, selective, and orally bioavailable CDK4/6 inhibitor with unique pharmacokinetic and pharmacodynamic properties, which result in high efficacy against CDK4/6 dependent tumors while minimizing the undesirable on-target bone marrow activity. |
CSN19744 | L-Sulforaphane | 142825-10-3 | (R)-Sulforaphane, a natural product isolated and purified from brocoli, is a promising potential chemopreventitive agent in bladder cancer. |
CSN19745 | Apicidin | 183506-66-3 | Apicidin is a potent histone deacetylase (HDAC) inhibitor with antiangiogenic and anti-invasive activity, which blocks proliferation of human stomach and breast cancer cells, and induces apoptosis and autophagy in human oral squamous carcinoma cells. |
CSN19724 | ALK Inhibitor C29 | 2093414-37-8 | ALK inhibitor C29 shows promising anti-ALK activities in enzymatic- and cell-based assays, while in vivo H3122 xenograft model study showed that it effectively suppressed ALK-driven tumor growth. |
CSN19736 | Bis(N,N '-disalicylidene)-1,2-cyclohexanediamine-cobalt(II) | 40784-65-4 | MEK1 inhibitor CL2 exhibits MEK1 binding affinity with IC50 71 nM, which is so far the best result for metal complexes and more potent than U0126(7.02 μM) and AZD6244(2.20 μM). |
CSN19728 | Lss-11 | 1392014-36-6 | LSS-11 bound to DNA in vitro and in cell mainly by minor groove binding and significantly increased the stability of DNA, which could be fundamental for the biological activities of LSS-11. It can inhibit multiple DNA-associated processes and tumor growth. |
CSN19755 | MBQ-167 | 2097938-73-1 | MBQ-167 is a dual Rac and Cdc42 inhibitor, potential to be developed as an anticancer drug. |
CSN19756 | Cdc7 inhibitor 7c | 1330781-04-8 | CDC7 inhibitor C10C is a high selective CDC7 inhibitor. |
CSN19758 | Debio 0617B | 1332329-27-7 | Debio 0617B is a mutiple kinase inhitor and can inhibit the growth of STAT3-Driven solid tumors through combined inhibition of JAK, SRC, and class III/V receptor tyrosine kinases.. |
CSN19733 | Ncd-38 | 1456907-39-3 | NCD-38 is a KDM1A-specific inhibitor to promote differentiation and apoptosis of glioma stem cells (GSCs). KDM1A inhibitor modulates several pathways related to stemness, differentiation and apoptosis. it can induce activation of the unfolded protein response (UPR) pathway. |
CSN19751 | Nisc-6 | 2097636-49-0 | NISC-6 is a napthalamide-isoselenocyanate compound which acts as a dual Topoisomerase-IIα and Akt pathway inhibitor. |
CSN19694 | Sb-fi-26 | 1541209-75-9 | SB-FI-26, an antinociceptive agent which binds to anandamide transporters FABP5 and FABP7, suppresses the proliferation, migration, invasiveness and colony formation of PC3-M cells in vitro. |
CSN19752 | CD161 | 1627716-22-6 | CD161 is a potent, selective, and orally active BET inhibitor. |
CSN19711 | CB-1158-analog | 1345810-21-0 | CB-1158 is a potent arginase inhibitor. CB-1158 has the potential for anti-tumor activity in renal cell cancer, breast cancer, non-small cell lung cancer, acute myeloid leukemia, and other tumor types where arginase-secreting MDSCs are known to play an immunosuppressive role. |
CSN19701 | Top-Tdp Tri Inhibitor C12 | 2092927-74-5 | Top-Tdp tri inhibitor C12 is one of the first triple inhibitors of human topoisomerase 1, tyrosyl–DNA phohosphodiesterase 1 (Tdp1), and tyrosyl–DNA phosphodiesterase 2 (Tdp2). |
CSN19705 | ASP5878 | 1453208-66-6 | ASP5878 is a selective FGFR inhibitor, to treat FGFR3-dependent urothelial cancer with or without chemoresistance. |
CSN19692 | Lt-626 | 1207456-03-8 | LT-626 functions as an effective radiosensitizer during fractionated radiation treatment, leading to significant decrease in tumor burden and doubling the median survival. |
CSN20998 | Dehydropachymic acid | 77012-31-8 | Dehydropachymic acid is extracted from the root of wolfiporia cocos (Schw.) Ryv. with antiinflammatory activity. |
CSN20998 | Dehydropachymic acid | 77012-31-8 | Dehydropachymic acid is extracted from the root of wolfiporia cocos (Schw.) Ryv. with antiinflammatory activity. |
CSN20998 | Dehydropachymic acid | 77012-31-8 | Dehydropachymic acid is extracted from the root of wolfiporia cocos (Schw.) Ryv. with antiinflammatory activity. |