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| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN19039 | PD150606 | 179528-45-1 | PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor (Ki values for ν and m-calpains are 0.21 and 0.37 μM respectively). |
| CSN19103 | HMN-176 | 173529-10-7 | HMN-176 is the active derivative of HMN-214 which can alter the cellular spatial orientation of Plk1. |
| CSN19078 | WNK463 | 2012607-27-9 | WNK463 is a potant With-No-Lysine (WNK) kinase inhibitor with IC50s of 5/1/6/9 nM for WNK1/2/3/4. |
| CSN19013 | Pamapimod | 449811-01-2 | Pamapimod is a selective inhibitor of p38 mitogen-activated protein kinase. It inhibits p38α and p38β enzymatic activity with IC50 values of 0.014±0.002 and 0.48± 0.04 mM, respectively with no activity against p38delta or p38gamma isoforms. |
| CSN19098 | Importazole | 662163-81-7 | Importazole is a small molecule inhibitor of the nuclear transport receptor importin-β. |
| CSN19020 | A-804598 | 1125758-85-1 | A-804598 is a competitive, and selective P2X7 receptor antagonist with IC50 of 10 nM, 9 nM and 11 nM in rat, mouse and human P2X7 receptors respectively. |
| CSN19072 | CPI-637 | 1884712-47-3 | CPI-637 is an efficient inhibitor of CBP/EP300 bromodomain with IC50 of 0.03 ± 0.01μM. |
| CSN19082 | Eltanexor | 1642300-52-4 | KPT-8602 is a second-generation and oral acitve exportin-1 (XPO1/CRM1) inhibitor with IC50 of 20−211 nM in 10 AML cell lines. |
| CSN19043 | PCC0208009 | 1668565-74-9 | IDO-IN-2 is an IDO inhibitor with IC50 value of 68 nM and 160 nM in HeLa cell and HEK293 cell, respectively. |
| CSN19081 | A-196 | 1982372-88-2 | A-196 is a potent and selective inhibitor of SUV420H1 and SUV420H2 with IC50s of 25 and 144 nM respectively. |
| CSN19090 | GNE-140 racemate | 1802977-61-2 | GNE-140 racemate is a LDHA inhibitor. |
| CSN19016 | APS-2-79 | 2002381-25-9 | APS-2-79 is an antagonist of MEK phosphorylation by RAF through direct binding of the KSR active site. |
| CSN19049 | PF-04957325 | 1305115-80-3 | PF-04957325 is a highly potent and selective PDE8 inhibitor, with IC50 values of 0.7 nM for PDE8A and less than 0.3 nM for PDE8B. |
| CSN19025 | D-3263 HCl | 1008763-54-9 | D-3263 HCl is an orally bioavailable (transient receptor potential melastatin member 8) TRPM8 agonist. |
| CSN19064 | N-(2-(((3-(4-Chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-4-methoxybenzenesulfonamide | 176708-42-2 | KN-92 is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM). |
| CSN19069 | GSK2983559 active metabolite | 1423186-80-4 | RIP2 kinase inhibitor 1 is a receptor interacting protein-2 (RIP2) kinase inhibitor. |
| CSN19054 | IDO-IN-3 | 2070018-30-1 | IDO-IN-3 is a potent IDO inhibitor. |
| CSN19033 | Monepantel | 887148-69-8 | Monepantel is organic anthelmintic, and acts as a positive allosteric modulator of a nematode-specific clade of nicotinic acetylcholine receptor (nAChR) subunits. |
| CSN19015 | Dehydrocorydaline chloride | 10605-03-5 | Dehydrocorydaline chloride is an alkaloidal that has anti-inflammatory and anti-cancer activities. |
| CSN19083 | Eltanexor Z-isomer | 1642300-78-4 | KPT-8602 Z-isomer is an isomer of KPT-8602, which is highly specific for XPO1 inhibition and demonstrates potent anti-leukemic activity. |
| CSN19068 | RIP2 kinase inhibitor 2 | 1581270-11-2 | RIP2 kinase inhibitor 2 is a receptor interacting protein-2 (RIP2) kinase inhibitor. |
| CSN19017 | Ravoxertinib HCl | 2070009-58-2 | GDC-0994 HCl is highly selective for ERK1 and ERK2, with biochemical potency of 1.1 nM and 0.3 nM, respectively. |
| CSN19066 | (+)-DHMEQ | 287194-41-6 | (+)-DHMEQ, the distomer of DHMEQ, is an inhibitor of NF-κB. |
| CSN19060 | Sophoflavescenol | 216450-65-6 | Sophoflavescenol is a prenylated flavonol, which shows great inhibitory activity with IC50 of 13 nM against phosphodiesterase 5 (PDE5), and also inhibits RLAR, HRAR, AGE, BACE1, AChE and BChE with IC50s of 0.30 μM, 0.17 μM, 17.89 μg/mL, 10.98 μM, 8.37 μM and 8.21 μM, respectively. |
| CSN19056 | AZ876 | 898800-26-5 | AZ876 is a high-affinity LXR agonist. |
| CSN19063 | N-(2-(((3-(4-Chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide phosphate | 1913269-12-1 | KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM). |
| CSN19120 | BBT594 | 882405-89-2 | BBT594 is a potentreceptor tyrosine kinase RET inhibitor, used for cancer treatment. |
| CSN19124 | PIM-447 2HCl | 1820565-69-2 | PIM-447 2HCl is pan-PIM kinase inhibitor, including Moloney Murine Leukemia (PIM)1, 2, and 3 Kinase. |
| CSN19052 | Seviteronel (R enantiomer) | 1375603-38-5 | VT-464 R-enantiomer is the R-enantiomer with unknown activity of VT-464, which is a potent CYP17 lyase inhibitor (h-Lyase IC50=69 nM). |
| CSN19037 | TAPI-2 | 187034-31-7 | TAPI-2 is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC50 of 20±10 μM for MMP. |
| CSN19042 | SYP-5 | 1384268-04-5 | SYP-5 is a HIF-1 inhibitor, suppresses tumor cells invasion and angiogenesis. |
| CSN19119 | Endoxifen (E-isomer) | 114828-90-9 | Endoxifen E-isomer is the E-isomer of (Z)-Endoxifen, which is an active metabolite generated via actions of CYP3A4/5 and CYP2D6, is a more potent selective estrogen receptor modulator (SERM) than Tamoxifen. |
| CSN19136 | Sotetsuflavone | 2608-21-1 | Sotetsuflavone is a potent inhibitor of DENV-NS5 RdRp (Dengue virus NS5 RNA-dependent RNA polymerase) with an IC50 of 0.16 μM, is the most active compound of this series . |
| CSN19109 | PSI-697 | 851546-61-7 | PSI-697is a P-selectin inhibitor. |
| CSN19130 | NSC 601980 | 2070018-27-6 | NSC601980 shows antitumor activity in the yeast screening experiment, which can inhibit cell proliferation in the COLO 205 and HT29 with Log GI 50 of -6.6 and -6.9 respectively. |
| CSN19023 | ML204 HCl | 2070015-10-8 | ML204 HCl is a potent, selective TRPC4 channel inhibitor with IC50 of 0.96 μM. |
| CSN19046 | FAS-IN-1 Tosylate | N/A | FAS-IN-1 tosylate is a potent inhibitor of fatty acid synthase (FAS) with an IC50 of 10 nM. |
| CSN19074 | RK-33 | 1070773-09-9 | RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells. |
| CSN19057 | (R,S)-Ivosidenib | 2070009-31-1 | (R,S)-Ivosidenib is an inhibitor of isocitrate dehydrogenase (IDH1). |
| CSN19094 | JPH203 | 1037592-40-7 | JPH203 is a potent and selective L-type amino acid transporter 1 (LAT1) inhibitor that can be used for cancer research. |
| CSN19075 | CCF642 | 346640-08-2 | CCF642 is a PDI-inhibiting compound with antimyeloma activity. |
| CSN19050 | GNE-617 HCl | 2070014-99-0 | GNE-617 HCl is a specific NAMPT inhibitor that inhibits the biochemical activity of NAMPT with an IC50 of 5 nM and exhibits efficacy in xenograft models of cancer. |
| CSN19051 | AP-III-a4 HCl | 2070014-95-6 | AP-III-a4 HCl is a small molecule which is the first, nonsubstrate analogue that directly binds to enolase and inhibits its activity (IC50=0.576 uM) and inhibit cancer cell metastasis in vivo. |
| CSN19012 | HO-3867 | 1172133-28-6 | HO-3867 selectively inhibits the phosphorylation and transcription of STAT3. It is an analog of curcumin. |
| CSN19059 | Mardepodect HCl | 2070014-78-5 | PF-2545920 is a potent and selective PDE10A inhibitor with IC50 of 0.37 nM, with > 1000-fold selectivity over the PDE. |
| CSN19079 | ML390 | 2029049-79-2 | ML390 is a human DHODH inhibitor that induces differentiation in acute myeloid leukemia. |
| CSN19061 | AZD3839 | 1227163-84-9 | AZD3839 is an inhibitor of BACE1 with IC50 of 23.6 uM. |
| CSN19055 | 4-((4'-(aminomethyl)-[1,1'-biphenyl]-3-yl)oxy)pyrimidine-2-carbonitrile hydrochloride | 2197053-49-7 | Cysteine protease inhibitor HCl is an inhibitor of cysteine protease. |
