CAS No.: 2070014-99-0
GNE-617 HCl Catalog No. CSN19050
GNE-617 HCl is a specific NAMPT inhibitor that inhibits the biochemical activity of NAMPT with an IC50 of 5 nM and exhibits efficacy in xenograft models of cancer.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Zabka TS, Singh J, et al. Retinal toxicity, in vivo and in vitro, associated with inhibition of nicotinamide phosphoribosyltransferase. Toxicol Sci. 2015 Mar;144(1):163-72.
- [2] Shames DS, Elkins K, et al. Loss of NAPRT1 expression by tumor-specific promoter methylation provides a novel predictive biomarker for NAMPT inhibitors. Clin Cancer Res. 2013 Dec 15;19(24):6912-23.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 2070014-99-0 | 储存条件 |
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| 分子式 | C21H16ClF2N3O3S | 运输 | 蓝冰 | |
| 分子量 | 463.88 | 别名 |
