Dopamine Receptor | GPCR/G Protein|Neuronal Signaling| CSNpharm

Dopamine Receptor

Dopamine Receptor
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货号	产品名	CAS号	信息
CSN26632	Zuclopenthixol	53772-83-1	Zuclopenthixol, also known as Cisordinol, Clopixol, Acuphase, zuclopentixol, is a typical antipsychotic drug of the thioxanthene class. It was introduced in 1962 by Lundbeck. Zuclopenthixol is the cis-isomer of clopenthixol. Zuclopenthixol is not approved for use in the United States. Zuclopenthixol has high affinity for both dopamine D1 and D2 receptors, for α1-adrenoceptors and 5-HT2 receptors but no affinity for cholinergic muscarine receptors. It has weak histamine (H1) receptor affinity and no α2-adrenoceptor blocking activity.
CSN20169	Zicronapine	170381-16-5	Zicronapine is an atypical antipsychotic medication. Zicronapine exhibits monoaminergic activity and has a multi-receptorial profile. In vitro and in vivo it has shown potent antagonistic effects at dopamine D1, D2 and serotonin 5HT2A receptors.
CSN26449	LY3154207	1638667-79-4	Y3154207 is a novel, potent, and subtype selective human D1 positive allosteric modulator (PAM) with minimal allosteric agonist activity (EC50 = 3 nM). In contrast to orthosteric agonists, LY3154207 showed a distinct pharmacological profile without a bell-shaped dose-response relationship or tachyphylaxis in preclinical models. Identification of a crystalline form of free LY3154207 from the discovery lots was not successful. Instead, a novel cocrystal form with superior solubility was discovered and determined to be suitable for development. LY3154207 is now in clinical development as a potential first-in-class D1 PAM for Lewy body dementia.
CSN21891	Veralipride	66644-81-3	Veralipride is an antagonist of D2 receptor. It is used for the treatment of menopausal symptoms.
CSN23250	Trimethobenzamide HCl	554-92-7	Trimethobenzamide HCl is a dopamine D2 receptor antagonist and antiemetic drug.
CSN12086	Tiamenidine	31428-61-2	Thioridazine is an antipsychotic drug, used in the treatment of schizophrenia and psychosis, shows D4 selectivity or serotonin antagonism.
CSN25548	(Rac)-Tavapadon	1643462-64-9	Tavapadon mixture is the mixture form of Tavapadon, 1,5-Dimethyl-6-[2-methyl-4-[[3-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]-2,4(1H,3H)-pyrimidinedione, while Tavapadon is the pure (-)-1,5-Dimethyl-6-[2-methyl-4-[[3-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]-2,4(1H,3H)-pyrimidinedione.
CSN28443	Tavapadon	1643489-24-0	Tavapadon is an orally active and highly selective dopamine D1/D5 receptor partial agonist. It may be useful in the treatment of Parkinson's disease and Alzheimer's.
CSN21847	N-((1-乙基吡咯烷-2-基)甲基)-5-(乙基磺酰基)-2-甲氧基苯甲酰胺	53583-79-2	Sultopride is a selective antagonist of dopamine D2 receptor.
CSN22118	Sultopride HCl	23694-17-9	Sultopride HCl is a selective antagonist of dopamine D2 receptor
CSN27219	SKF-83566	99295-33-7	SKF-83566 is a potent, blood-brain permeable and orally active dopamine D1/D5 receptor antagonist . SKF-83566 is a competitive DAT (dopamine transporter) inhibitor with an IC50 of 5.7 μM and attenuates cocaine effects in vivo .
CSN18415	SKF-82958 hydrobromide	74115-01-8	SKF-82958 hydrobromide is a D1/D5 receptor full agonist.
CSN20415	SKF 83959 HBr	67287-95-0	SKF 83959 hydrobromide is a dopamine D1-like receptor partial agonist (Ki values are 1.18, 7.56, 920 and 399 nM for rat D1, D5, D2 and D3 receptors respectively). It may act as an antagonist in vivo, producing anti-Parkinsonian effects and antagonizing the behavioral effects of cocaine.
CSN23554	SCH-23390 HCl	125941-87-9	SCH 23390 HCl is an antagonist of dopamine receptor D1 and D5 with Ki of 0.2 nM and 0.3 nM, respectively.
CSN26532	Sarizotan	351862-32-3	Sarizotan (EMD 128130) is an orally active serotonin 5-HT1A receptor and dopamine receptor agonist. Sarizotan (EMD 128130) exhibits IC50 values of 6.5 nM (rat 5-HT1A), 0.1 nM (human 5-HT1A), 15.1 nM (rat D2), 17 nM (human D2), 6.8 nM (human D3) and 2.4 nM (human D4.2), respectively[1].
CSN23655	Ro 10-5824 2HCl	189744-94-3	Ro 10-5824 2HCl is an agonist of dopamine D4 receptor with Ki of 5.2 nM.
CSN21076	SCH-23390 maleate	87134-87-0	Potent dopamine receptor antagonist (Ki values are 0.2 nM and 0.3 nM at D1 and D5 receptor sub-types, respectively). Also an agonist at 5-HT1C and 5-HT2C receptors in vitro (Ki values are 6.3 nM and 9.3 nM respectively). Blocks quinpirole-induced Kir3 (GIRK) currents (EC50 = 268 nM) independently of receptors.
CSN23235	PD168,077	190383-31-4	PD168,077 is a dopamine D4 receptor agonist which has a facilitatory effect on memory consolidation.
CSN23271	PD-168077 maleate	630117-19-0	PD 168077 maleate is an agonist of D4 dopamine receptor with Ki of 8.7 nM. It can induce synaptic translocation of CaMK II to postsynaptic sites in cultured prefrontal cortical neurons.
CSN18173	Pardoprunox HCl	269718-83-4	Pardoprunox HCl is a partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist, D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist and 5-HT1A receptor (pKi = 8.5) full agonist.
CSN19863	N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butyl)-9H-fluorene-2-carboxamide hydrochloride	189061-11-8	NGB 2904 is a potent and selective dopamine D3 receptor antagonist (Ki values are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D3, D2, 5-HT2, α1, D4, D1 and D5 receptors respectively).
CSN26125	ML417	1386162-69-1	ML417 is a novel and highly selective D3 dopamine receptor agonist with EC50 value of 38nM.
CSN19492	Metoclopramide HCl hydrate	54143-57-6	Metoclopramide HCl is an antagonist of dopamine D2 receptor that is structurally related to procainamide. It has antiemetic and gastroprokinetic activities.
CSN23832	Mesoridazine benzenesulfonate	32672-69-8	Mesoridazine besylate is a phenothiazine dopamine receptor anatagonist. Mesoridazine besylate is described to demonstrate inhibition for D2DR and D4DR. It has a high affinity for dopamine D4 receptor. Mesoridazine besylate is an antipsychotic agent.
CSN23381	Melitracen HCl	10563-70-9	Melitracen HCl, a member of anthracenes, is an antagonist of dopamine D1 and D2 receptors. It is used as an antidepressant.
CSN21902	Lurasidone	367514-87-2	Lurasidone functions as an antagonist of the dopamine D2 and D3 receptors, the serotonin 5-HT2A and 5-HT7 receptors, the α2C-adrenergic receptor, and as a partial agonist of the serotonin 5-HT1A receptor.
CSN19476	4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone	52-86-8	Haloperidol is an antagonist of dopamine D2-like receptors (D1-D5) and it is used as a typical antipsychotic.
CSN20158	GSK598809	863680-45-9	GSK598809 is a selective D(3)R antagonist recently progressed in Phase I trials. GSK-598809 may decrease the rewarding effects of contextual cues associated with drug intake preclinically, which may reduce drug craving in humans.
CSN18457	GSK163090	844903-58-8	GSK163090 is a potent, selective, and orally active 5-HT1A/B/D receptor antagonist with pKi of 9.4/8.5/9.7, and 6.3/6.7 for dopamine D2/D3, respectively.
CSN27239	Fluphenazine	69-23-8	Fluphenazine is a typical antipsychotic used for symptomatic management of psychosis in patients with schizophrenia.
CSN22033	Dixyrazine	2470-73-7	Dixyrazine, a phenothiazine derivative, can prevent brain oedema induced by intracarotid injection of protamine sulphate.
CSN18775	Chlorprothixene	113-59-7	Chlorprothixene is an antagonist of multiple receptors including 5-HT2 (Ki = 3.4 nM), D1 (Ki = 18 nM), D2 (Ki = 18 nM), D3 (Ki = 4.56 nM), H1 (Ki = 3.75 nM), muscarinic acetylcholine receptors, α1-Adrenergic.
CSN19084	CGP 25454A	104391-26-6	CGP 25454A is a selective presynaptic dopamine autoreceptor antagonist.
CSN20529	BP 897 HCl	314776-92-6	BP897 is a partially selective dopamine D3 receptor agonist (Ki = 0.92 nM) that developed for the study of cocaine addiction.
CSN18441	4-Amino-N-((1-ethylpyrrolidin-2-yl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide hydrochloride	81342-13-4	Amisulpride HCl is an antipsychotic drug, which is a selective dopamine antagonist (Ki=2.8 nM D2 receptor; Ki=3.2 nM D3 receptor).
CSN18125	Adoprazine	222551-17-9	Adoprazine, a potential atypical antipsychotic bearing potent D2 receptor antagonist and 5-HT1A receptor agonist properties.
CSN25294	2-((4-(Pyridin-2-yl)piperazin-1-yl)methyl)-1H-benzo[d]imidazole	70006-24-5	ABT-724 is a potent and highly selective dopamine D4 receptor agonist with EC50s of 12.4 nM, 14.3 nM and 23.2 nM for human dopamine D4 receptor, rat D4 receptor and ferret D4 receptor.
CSN25293	ABT-724 3HCl	587870-77-7	ABT-724 3HCl is a potent and highly selective dopamine D4 receptor agonist with EC50s of 12.4 nM, 14.3 nM and 23.2 nM for human dopamine D4 receptor, rat D4 receptor and ferret D4 receptor.
CSN21450	Abaperidone	183849-43-6	Abaperidone is an antagonist of 5-HT2A receptor and dopamine D2 receptor with IC50s of 6.2 and 17 nM respectively.
CSN24069	A-381393	726174-00-1	A-381393 is a potent, selective, brain penetrate dopamine D4 receptor antagonist, with Kis of 1.5, 1.9 and 1.6 nM for human dopamine D4.4, D4.2, and D4.7 receptor, respectively, >2700-fold selectivity over D1, D2, D3 and D5 dopamine receptors. A-381393 shows moderate affinity for 5-HT2A (Ki, 370 nM)[1].
CSN22612	(4aR,10bR)-4-Propyl-3,4,4a,10b-tetrahydro-2H,5H-chromeno[4,3-b][1,4]oxazin-9-ol hydrochloride	300576-59-4	(+)-PD 128,907 HCl is an agonist of D3 dopamine receptor with Ki of 2.3 nM.
CSN22323	(+)-Dihydrexidine HCl	158704-02-0	(+)-Dihydrexidine HCl is a dopamine D1 receptor agonist with an EC50 of 72± 21 nM.
CSN25685	(+)-AJ 76 HCl	85378-82-1	(+)-AJ 76 hydrochloride is an antagonist of dopamine receptor with preferential action at presynaptic receptors (pKi values are 6.95, 6.67, 6.37, 6.21 and 6.07 at hD3, D4, hD2S, hD2L and rD2 receptors respectively).
CSN52402	3-((4-(4-Chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridine	158985-00-3

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