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CAS No.: 125941-87-9

SCH-23390 HCl Catalog No. CSN23554

Synonyms: R-(+)-SCH-23390 hydrochloride;SCH 23390 (hydrochloride);SCH-23390

SCH 23390 HCl is an antagonist of dopamine receptor D1 and D5 with Ki of 0.2 nM and 0.3 nM, respectively.

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生物活性

描述Dopamine receptors have been associated with many neurological disorders, including most notably Parkinson's disease and schizophrenia. SCH 23390 is a highly potent and selective dopamine D1-like receptor antagonist with a Ki of 0.2 and 0.3 nM for the D1 and D5 dopamine receptor subtypes, respectively. SCH 23390 HCl is the hydrochloride form of SCH 23390. SCH 23390 also binds with high affinity to the 5-HT2 and 5-HT1C serotonin receptor subtypes^[1]. Intra-DLS (dorsolateral striatum) microinfusion of SCH23390 (100 ng) or sulpiride both increased anxiety, indicated by increases in time spent in the enclosed maze arms in rats, while intra-DMS (dorsomedial striatum) microinfusion of SCH23390, sulpiride, or saline did not affect performance in a novelty preference test, indicated by greater time spent in a 'novel' maze arm compared to 'non-novel' arms^[2]. In contextual fear conditioning and memory testing, SCH23390 (0.1 mg/kg) given before conditioning or before both conditioning and retrieval decreased freezing at retrieval, whereas SCH23390 given only before retrieval had no effect. SCH23390 (2.5 μg/0.5 uL) infused into dmPFC (dorsomedial prefrontal cortex) before conditioning decreased freezing at retrieval, while infusion of SCH23390 into NAc (nucleus accumbens) or VH (ventral hippocampus) had no effect^[3].
参考文献

[1] Bourne JA. SCH 23390: the first selective dopamine D1-like receptor antagonist. CNS Drug Rev. 2001;7(4):399‐414.
[2] Nguyen D, Alushaj E, Erb S, Ito R. Dissociative effects of dorsomedial striatum D1 and D2 receptor antagonism in the regulation of anxiety and learned approach-avoidance conflict decision-making. Neuropharmacology. 2019;146:222‐230.
[3] Stubbendorff C, Hale E, Cassaday HJ, Bast T, Stevenson CW. Dopamine D1-like receptors in the dorsomedial prefrontal cortex regulate contextual fear conditioning. Psychopharmacology (Berl). 2019;236(6):1771‐1782.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.0841 mL
- 15.4204 mL
- 30.8409 mL
- 5 mM
- 0.6168 mL
- 3.0841 mL
- 6.1682 mL
- 10 mM
- 0.3084 mL
- 1.5420 mL
- 3.0841 mL

技术信息

CAS号

125941-87-9

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C17H19Cl2NO

运输

蓝冰

分子量

324.24

别名

R-(+)-SCH-23390 hydrochloride;SCH 23390 (hydrochloride);SCH-23390

溶解度

DMSO	200.0 mg/mL (616.8 mM)
Water	50.0 mg/mL (154.2 mM) warming

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