|N-(4-(2-(二甲基氨基)乙氧基)苄基)-3,4,5-三甲氧基苯甲酰胺盐酸盐|CsnPharm

CAS No.: 554-92-7

Trimethobenzamide HCl/盐酸三甲氧苯酰胺 Catalog No. CSN23250

Synonyms: Ro 2-9578;Trimethobenzamide (hydrochloride);Tebamide

Trimethobenzamide HCl is a dopamine D2 receptor antagonist and antiemetic drug.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Trimethobenzamide HCl is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting. Trimethobenzamide is a (non-phenothiazine) benzamide antiemetic that acts centrally to block D2 receptors, thereby inhibiting the medullary chemoreceptor trigger zone by blocking emetic impulses to the vomiting center^[1]. Trimethobenzamide was shown to be significantly better than placebo in relieving periodic and total nausea over the 48-hour study. Vomiting incidence was also reduced in the group receiving trimethobenzamide^[2]. Trimethobenzamide HCl was found to have more toxic and teratogenic potential on embryonic growth and development in cultured rat embryos^[3]. Open-label studies suggest that the combination of trimethobenzamide and diphenhydramine (TMB/DPH) may provide effective relief in a high proportion of migraineurs^[4]. In utero TMB (Trimethobenzamide) exposure may cause growth retardation, neurological damage in the developing brain and intestine, and hepatic damage^[5].
临床研究
NCT号适应症或疾病临床期招募状态预计完成时间地点
NCT00626327 Meningococcal Infections Phase 3 Completed - -
NCT00626327 - - Completed - -
NCT00806195 - - Completed - -
更多
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3534 mL
- 11.7669 mL
- 23.5338 mL
- 5 mM
- 0.4707 mL
- 2.3534 mL
- 4.7068 mL
- 10 mM
- 0.2353 mL
- 1.1767 mL
- 2.3534 mL

技术信息

CAS号

554-92-7

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H29ClN2O5

运输

蓝冰

分子量

424.92

别名

Ro 2-9578;Trimethobenzamide (hydrochloride);Tebamide;Ticon;trimethobenzamide;trimethobenzamide monohydrochloride;trade names Tebamide;盐酸曲美苄胺;盐酸三甲氧苯酰胺

溶解度

DMSO	195.0 mg/mL (458.9 mM)
Water	175.0 mg/mL (411.8 mM)

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00626327	Meningococcal Infections	Phase 3	Completed	-	-
NCT00626327	-	-	Completed	-	-
NCT00806195	-	-	Completed	-	-
NCT01345630	HIV-1	Phase 3	Terminated(See termination rea... more >>son in detailed description.) Collapse <<	-	-
NCT02556372	Autoimmune Hepatitis	Phase 2	Active, not recruiting	December 2018	United States, California ... more >> Ruane Clinical Research Group, Inc. Los Angeles, California, United States, 90036 University of California Davis Medical Center - Ticon 1 Sacramento, California, United States, 95817 California Pacific Medical Center San Francisco, California, United States United States, Florida University of Florida Hepatology Research at CTRB Gainesville, Florida, United States, 32610-0272 United States, Illinois Northwestern University Chicago, Illinois, United States, 60611 United States, Indiana Indiana University School of Medicine Indianapolis, Indiana, United States, 46202 United States, Louisiana Tulane University New Orleans, Louisiana, United States United States, Massachusetts Massachusetts General Hospital Boston, Massachusetts, United States United States, New York Mount Sinai Hospital New York, New York, United States, 10029 United States, North Carolina Duke University Medical Center Durham, North Carolina, United States, 27710 United States, Texas Methodist Dallas Medical Center Dallas, Texas, United States, 75203 Advanced Liver Therapies, Baylor College of Medicine Houston, Texas, United States, 77030 The Texas Liver Institute San Antonio, Texas, United States, 78215 Taxes Liver Institute San Antonio, Texas, United States United States, Washington Swedish Medical Center - Organ Transplant and Liver Center Seattle, Washington, United States, 98104 University of Washington Seattle, Washington, United States, 98104 Collapse <<
NCT00834704	Solid Tumor	Phase 1	Completed	-	United States, Arizona ... more >> T Gen Clinical Research Services Scottsdale, Arizona, United States, 85258 United States, California Premiere Oncology Santa Monica, California, United States, 90404 United States, Tennessee Sarah Cannon Research Institute Nashville, Tennessee, United States, 37203 Collapse <<
NCT00397748	-	-	Completed	-	United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse <<
NCT00806195	Meningitis Me... more >>ningococcal Infection Collapse <<	Phase 3	Completed	-	-
NCT01345630	-	-	Terminated(See termination rea... more >>son in detailed description.) Collapse <<	-	-
NCT01882465	Refractive Error	Not Applicable	Terminated	-	Hong Kong ... more >> Hong Kong Polytechnic University Hong Hom, Kowloon, Hong Kong Collapse <<
NCT01882465	-	-	Terminated	-	-
NCT00029510	Asthma	Phase 2	Completed	-	United States, California ... more >> University of California at Davis School of Medicine, Ticon 1, Suite 100B, 2000 Stockton Blvd Sacramento, California, United States, 95817 Collapse <<
NCT02373072	Idiopathic Parkinson Disease	Phase 1	Completed	-	United States, California ... more >> Collaborative Neuroscience Network, LLC. Long Beach, California, United States, 90806 United States, Florida MD Clinical Hallandale, Florida, United States, 33009 United States, Georgia Atlanta Center for Medical Research Atlanta, Georgia, United States, 30331 United States, Maryland SNBL Clinical Pharmacology Center, Inc. Baltimore, Maryland, United States, 21201 Parkinson's Movement Disorder Center of Maryland Elkridge, Maryland, United States, 21075 United States, Texas Neurology Consultants of Dallas, PA Dallas, Texas, United States, 75231 Walnut Hill Medical Center Dallas, Texas, United States, 75231 Belgium Pfizer Clinical Research Unit Brussels, Belgium, B-1070 Collapse <<
NCT01770145	Parkinson's Disease ... more >> Motor Symptoms Akinesia Hypomobility Delayed Levodopa Onset Collapse <<	Phase 4	Completed	-	United States, California ... more >> Keck School of Medicine Los Angeles, California, United States, 90033 Neurosearch, Inc. Reseda, California, United States, 91335 United States, District of Columbia Georgetown University Washington, D.C., District of Columbia, United States, 20007 United States, Florida Parkinson's Disease and Movement Disorders Center of Boca Raton Boca Raton, Florida, United States, 33486 United States, Illinois Rush University Medical Center Chicago, Illinois, United States, 60612 United States, Michigan Henry Ford West Bloomfield Hospital Bloomfield Hills, Michigan, United States, 48322 United States, New York Parkinson's Disease and Movement Disorders Center of New York Commack, New York, United States, 11725 United States, Ohio University of Cincinnati Academic Health Center Cincinnati, Ohio, United States, 45267 University Hospitals Case Medical Center Cleveland, Ohio, United States, 44106 United States, Oklahoma The Movement Disorder Clinic of Oklahoma Tulsa, Oklahoma, United States, 74136 United States, Texas University of Texas Health Science Center, Houston, Department of Neurology Houston, Texas, United States, 77030 Center for Neurological Care and Research San Antonio, Texas, United States, 78240 Collapse <<
NCT01770145	-	-	Completed	-	-
NCT00489255	Parkinson's Disease	Phase 4	Completed	-	-
NCT02262767	Healthy	Phase 1	Completed	-	Belgium ... more >> Belgium Pfizer Clinical Research Unit Brussels, Belgium, 1070 Pfizer Clinical Research Unit Brussels, Belgium, B-1070 Collapse <<
NCT00489255	-	-	Completed	-	-
NCT00536185	Heart Disease	Not Applicable	Completed	-	United States, California ... more >> UC Davis, Western Human Nutrition Research Center Davis, California, United States, 95616 Ethnich Health Institute Oakland, California, United States, 94609 UC Davis (TICON-1) Sacramento, California, United States, 95820 Collapse <<
NCT03164551	Infertility	Phase 4	Recruiting	March 30, 2020	Canada ... more >> Cambrian Wellness Centre Recruiting Calgary, Canada, T3B 4N2 Denmark Skive Fertility clinic Recruiting Skive, Denmark, 7800 France Hopital Antoine Beclere Not yet recruiting Clamart, France, 92140 Italy Krankenhaus Bruneck Not yet recruiting Bruneck (BZ), Italy, I-39031 Demetra S.R.L Not yet recruiting Firenze, Italy, 50141 Futura Diagnostica medica PMA SRL Not yet recruiting Firenze, Italy, SO129 Unita' di medicina della riproduzione - centro Hera Withdrawn Sant'Agata Li Battiali(CT), Italy, 95030 USL Toscana Nordovest Not yet recruiting Viareggio, Italy, 55043 Norway Oslo University Hospital Recruiting Oslo, Norway Contact +49 6151 72 5200 Sykehuset Telemark HF Fertilitetsavdeliningen Sor Recruiting Skien, Norway, 3710 St. Olavs Hospital Hf, Universitetssykehuset i Trondheim Recruiting Trodheim, Norway, N-7006 Portugal Centro Hospitalar e Universitario de Coimbra Recruiting Coimbra, Portugal, 3000-075 Spain Hospital de Cruces Recruiting Baracaldo, Spain, 48903 Nephrology Service Fundacion Puigvert Recruiting Barcelona, Spain, 8025 Hospital Universitario Virgen de las Nieves Recruiting Granada, Spain Hosp Univ de Canarias Not yet recruiting Santa Cruz de Tenerife, Spain United Kingdom Barts Health Centre for Reproductive medicine Withdrawn London, United Kingdom, EC1A7BE Collapse <<

Trimethobenzamide HCl/盐酸三甲氧苯酰胺 Catalog No. CSN23250

靶点选择性

请登录您的专属账户

确认信息