CAS No.: 863680-45-9
GSK598809 Catalog No. CSN20158
GSK598809 is a selective D(3)R antagonist recently progressed in Phase I trials. GSK-598809 may decrease the rewarding effects of contextual cues associated with drug intake preclinically, which may reduce drug craving in humans.
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纯度 & 质量文件
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生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00513279 Substance Dependence Phase 1 Completed - United Kingdom ... more >> GSK Investigational Site Harrow, Middlesex, United Kingdom, HA13UJ Collapse << NCT00793468 Substance Dependence Phase 2 Withdrawn(Study halted prior t... more >>o enrollment of patients) Collapse << December 2008 United States, Florida ... more >> GSK Investigational Site Deland, Florida, United States, 32720 GSK Investigational Site Pembroke Pines, Florida, United States, 33024 United States, Georgia GSK Investigational Site Stockbridge, Georgia, United States, 30281 United States, Kansas GSK Investigational Site Overland Park, Kansas, United States, 66211 United States, Nevada GSK Investigational Site Las Vegas, Nevada, United States, 89104 United States, New York GSK Investigational Site Rochester, New York, United States, 14609 United States, North Carolina GSK Investigational Site Raleigh, North Carolina, United States, 27612 United States, Oregon GSK Investigational Site Portland, Oregon, United States, 97239 United States, Pennsylvania GSK Investigational Site Philadelphia, Pennsylvania, United States, 19104 United States, Texas GSK Investigational Site Dallas, Texas, United States, 75234 Collapse << NCT01039454 Substance Dependence Phase 1 Completed - United Kingdom ... more >> GSK Investigational Site Cambridge, Cambridgeshire, United Kingdom, CB2 0QQ GSK Investigational Site London, United Kingdom, NW10 7EW Collapse << - 更多
- 参考文献
- [1] Appel NM, Li SH, et al. Dopamine D3 Receptor Antagonist (GSK598809) Potentiates the Hypertensive Effects of Cocaine in Conscious, Freely-Moving Dogs. J Pharmacol Exp Ther. 2015 Sep;354(3):484-92.
- [2] Nathan PJ, O'Neill BV, et al. The effects of the dopamine D₃ receptor antagonist GSK598809 on attentional bias to palatable food cues in overweight and obese subjects. Int J Neuropsychopharmacol. 2012 Mar;15(2):149-61.
实验方案
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- 储存液制备
技术信息
| CAS号 | 863680-45-9 | 储存条件 |
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| 分子式 | C22H23F4N5OS | 运输 | 蓝冰 | |
| 分子量 | 481.51 | 别名 |
