CAS No.: 67287-95-0
SKF 83959 HBr/SKF 83959氢溴酸盐 Catalog No. CSN20415
Synonyms: SKF 83959 (hydrobromide);SKF-83959 HBr;SKF-83959
SKF 83959 hydrobromide is a dopamine D1-like receptor partial agonist (Ki values are 1.18, 7.56, 920 and 399 nM for rat D1, D5, D2 and D3 receptors respectively). It may act as an antagonist in vivo, producing anti-Parkinsonian effects and antagonizing the behavioral effects of cocaine.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Zhang J, Chen X, et al. Synthesis of 6-substituted 1-phenylbenzazepines and their dopamine D(1) receptor activities. Bioorg Med Chem. 2008 Nov 1;16(21):9425-31.
- [2] Jutkiewicz EM, Bergman J. Effects of dopamine D1 ligands on eye blinking in monkeys: efficacy, antagonism, and D1/D2 interactions. J Pharmacol Exp Ther. 2004 Dec;311(3):1008-15.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 67287-95-0 | 储存条件 |
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| 分子式 | C18H21BrClNO2 | 运输 | 蓝冰 | |
| 分子量 | 398.72 | 别名 | SKF 83959 (hydrobromide);SKF-83959 HBr;SKF-83959 |
