CAS No.: 1638667-79-4
LY3154207 Catalog No. CSN26449
Synonyms: Mevidalen free base
Y3154207 is a novel, potent, and subtype selective human D1 positive allosteric modulator (PAM) with minimal allosteric agonist activity (EC50 = 3 nM). In contrast to orthosteric agonists, LY3154207 showed a distinct pharmacological profile without a bell-shaped dose-response relationship or tachyphylaxis in preclinical models. Identification of a crystalline form of free LY3154207 from the discovery lots was not successful. Instead, a novel cocrystal form with superior solubility was discovered and determined to be suitable for development. LY3154207 is now in clinical development as a potential first-in-class D1 PAM for Lewy body dementia.
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纯度 & 质量文件
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技术信息
| CAS号 | 1638667-79-4 | 储存条件 |
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| 分子式 | C24H29Cl2NO3 | 运输 | 蓝冰 | |
| 分子量 | 450.40 | 别名 | Mevidalen free base |
