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| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN10343 | α-Spinasterol | 481-18-5 | α-Spinasterol is an efficacious and safe antagonist of the TRPV1 receptor with antinociceptive effect. |
| CSN16412 | SN 2 | 823218-99-1 | SN 2 is a potent activator of TRPML3 ion channel with EC50 of 1.8±0.13 μM. |
| CSN15682 | (R)-1-(2-Bromophenyl)-3-(1-(5-(trifluoromethyl)pyridin-2-yl)pyrrolidin-3-yl)urea | 501951-42-4 | SB-705498 is a selective antagonist of transient receptor potential vanilloid 1 (TRPV1) with pIC50 of 7.1. |
| CSN12436 | SAR7334 HCl | 1333207-63-8 | SAR7334 2HCl is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM. |
| CSN17628 | RQ-00203078 | 1254205-52-1 | RQ-00203078 is a selective antagonist of TRPM8 with IC50 of 8.3 nM. |
| CSN18624 | RN-1734 | 946387-07-1 | RN-1734 is selective antagonist of the TRPV4 channel, completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC50 values for all three species (hTRPV4: IC50 = 2.3 μM, mTRPV4: IC50 = 5.9 μM, rTRPV4: IC50 = 3.2 μM). |
| CSN18152 | Pyr6 | 245747-08-4 | Pyr6 is a selective inhibitor of TRPC3 with IC50 of 0.49 μM (Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells). |
| CSN17688 | Pyr10 | 1315323-00-2 | Pyr 10 is a TRPC3-selective inhibitor. IC50 of Ca2+ influx inhibition by Pyr10 in carbachol-stimulated YFP-TRPC3-transfected HEK293 cells for ROCE and thapsigargin-depleted native RBL-2H3 cells for SOCE is 0.72 uM and 13.08 uM. |
| CSN13939 | PF-4840154 | 1332708-14-1 | PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse, with EC50 of 97 nM and 23 nM for rTrpA1 and hTrpA1, respectively. |
| CSN17365 | Optovin | 348575-88-2 | Optovin is a reversible and photoactive activator of TRPA1 with EC50 of 2 μM in wild-type zebrafish. |
| CSN16213 | N-(4-Hydroxy-3-methoxybenzyl)nonanamide | 2444-46-4 | Nonivamide, an analog of capsaicin, is agonist of transient receptor potential vanilloid type 1 (TRPV1). It can be extracted from the fruits of Capsicum annuum L.. |
| CSN15766 | ML204 | 5465-86-1 | ML204 is a selective antagonist of TRPC4 ion channel with IC50 of 0.96 μM and 2.6 μM in fluorescent and electrophysiological assays respectively. |
| CSN18632 | Mavatrep | 956274-94-5 | Mavatrep is an orally bioavailable TRPV1 antagonist (Ki=6.5 nM), exhibits minimal effect on the enzymatic activity (IC50 > 25 μM) of CYP isoforms 3A4, 1A2, and 2D6. |
| CSN18446 | JNJ-17203212 | 821768-06-3 | JNJ-17203212 is a selective TRPV1 antagonist, with IC50 of 65 nM and 102 nM for human TRPV1 and rat TRPV1. |
| CSN16140 | Icilin | 36945-98-9 | Icilin is an agonist of TRPM8 ion channel with EC50 of 0.36 μM in HEK 293 cells. |
| CSN16823 | HC-030031 | 349085-38-7 | HC-030031 is a blocker of TRPA1 channel that exhibits antagonistic effect on AITC- and formalin-evoked calcium influx with IC50 of 6.2 μM and 5.3 μM respectively. |
| CSN18613 | GSK1016790A | 942206-85-1 | GSK1016790A is a potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34nM in choroid plexus epithelial cells. |
| CSN18220 | Chembridge-5861528 | 332117-28-9 | Chembridge-5861528 is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx (IC50 values are 14.3 and 18.7μM respectively). |
| CSN10542 | Capsazepine | 138977-28-3 | Capsazepine is an antagonist of TRPV1 receptor with IC50 of 562 nM. It is synthetic analogue of sensory neurone excitotoxin. |
| CSN10541 | (E)-N-(4-Hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide | 404-86-4 | Capsaicin is an agonist of TRPV1 with EC50 of 0.29 ± 0.05 μM in HEK293 cells. It is active component of chili peppers. |
| CSN15352 | Bisandrographolide A | 160498-00-0 | Bisandrographolide A, a natural product, activates TRPV4 channels, could play a role in some of the effects of Andrographis extract described in traditional medicine. |
| CSN16141 | BCTC | 393514-24-4 | BCTC is a potent and specific inhibitor of transient receptor potential cation channel subfamily M member 8 (TRPM8) in prostate cancer (PCa) DU145 cells. |
| CSN16537 | AMG 517 | 659730-32-2 | AMG-517 is a potent and selective TRPV1 antagonist, and antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM. |
| CSN12433 | 6-Gingerol | 23513-14-6 | 6-Gingerol is activator transient receptor potential vanilloid receptor TRPV1 and TRP ankyrin receptor TRPA1 with EC50 of 3.3 µM and 10.4 µM. It's a natural chemical found in the rhizomes of ginger (Z. officinale). |
