393514-24-4|BCTC|CsnPharm

CAS No.: 393514-24-4

BCTC Catalog No. CSN16141

BCTC is a potent and specific inhibitor of transient receptor potential cation channel subfamily M member 8 (TRPM8) in prostate cancer (PCa) DU145 cells.

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描述BCTC is a potent and specific inhibitor of transient receptor potential cation channel subfamily M member 8 (TRPM8) in prostate cancer (PCa) DU145 cells. BCTC exerts an anti-proliferative effect on DU145 cells and induces tumor suppression through G0/G1 cell cycle arrest, and inhibition of migration and invasion. BCTC demonstrates excellent anti-tumor activity in PCa DU145 cells, and therefore has the potential to become a targeted therapeutic strategy against PCa^[3]. Administration of BCTC (30 mg/kg p.o.) significantly reduced both mechanical and thermal hyperalgesia induced by intraplantar injection of 30 micro g of capsaicin. In rats with Freund's complete adjuvantinduced inflammation, BCTC significantly reduced the accompanying thermal and mechanical hyperalgesia (3 mg/kg and 10 mg/kg p.o., respectively). BCTC also reduced mechanical hyperalgesia and tactile allodynia 2 weeks after partial sciatic nerve injury (10 and 30 mg/kg p.o.)^[4]. Moreover, of the TRPV-1 receptor antagonists studied, BCTC (1μM) seems the most reliable in isolated organ experiments. This substance is also effective in the human intestine^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02759536	Melanoma Boro... more >>n Neutron Capture Therapy Collapse <<	Phase 1 Phase 2	Unknown	-	China, Hunan ... more >> The Third Xiangya Hospital of Central South University Recruiting Changsha, Hunan, China, 410013 Contact: Shaihong Zhu, M.D. +86 15802537999 thomasze2007@163.com Principal Investigator: Shaihong Zhu, M.D. Sub-Investigator: Zhong Yong, M.D. Sub-Investigator: Zewen Song, M.D. Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.6817 mL
- 13.4087 mL
- 26.8174 mL
- 5 mM
- 0.5363 mL
- 2.6817 mL
- 5.3635 mL
- 10 mM
- 0.2682 mL
- 1.3409 mL
- 2.6817 mL

技术信息

CAS号

393514-24-4

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H25ClN4O

运输

蓝冰

分子量

372.89

别名

溶解度

DMSO	12.33 mg/mL (33.1 mM)
Water	insoluble

动物实验配方

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