|N-(4-氯-2-氟苯基)-6,7-二甲氧基喹唑啉-4-胺|CsnPharm

CAS No.: 690206-97-4

ZM 306416 Catalog No. CSN15826

Synonyms: CB 676475

ZM-306416 is an inhibitor of VEGFR (Flk-1 or KDR) and Flt with IC50 of 100 nM and 2 μM. It also shows inhibition activity against Src and Abl with IC50 values of 0.33μM and 1.3μM, respectively.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 VEGFR2

IC50:100nM VEGFR1

IC50:2μM
描述ZM-306416, a vascular endothelial growth factor receptor (VEGFR) antagonist, was identified as a potent inhibitor of EGFR function^[3]. The VEGFR1/2 inhibitors, ZM306416 and KRN633, lead to a dose-dependent decrease in mineralization^[4]. ZM-306416 induced selective anti-proliferative effect toward the EGFR addicted NSCLC cell lines H3255 and HCC4011 (IC50=0.09±0.007 μM and 0.072±0.001 μM respectively), while sparing the wild type EGFR cell lines A549 and H2030 (IC50>10 μM). ZM-306416 is also found to inhibit the ABL in vitro kinase activity with a less potent IC50 value of 1.3±0.2 μM toward the ABL kinase^[3]. Ki8751, a selective VEGFR2 inhibitor, completely suppressed the effect of VEGF121 on SCE cell permeability, although ZM306416, a selective VEGFR1 inhibitor, did not affect the VEGF121-induced decrease in TEER (transendothelial electrical resistance)^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.9963 mL
- 14.9815 mL
- 29.9630 mL
- 5 mM
- 0.5993 mL
- 2.9963 mL
- 5.9926 mL
- 10 mM
- 0.2996 mL
- 1.4982 mL
- 2.9963 mL

技术信息

CAS号

690206-97-4

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H13ClFN3O2

运输

蓝冰

分子量

333.74

别名

CB 676475

溶解度

DMSO	67.0 mg/mL (200.8 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

靶点	Description	IC50
VEGFR2		IC50:100nM
VEGFR1		IC50:2μM

ZM 306416 Catalog No. CSN15826

靶点选择性

请登录您的专属账户

确认信息