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CAS No.: 49671-76-3

ZLN005 Catalog No. CSN15985

Synonyms: ZLN005

ZLN005 is a transcriptional regulator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α).

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技术信息

生物活性

描述Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a key regulator of energy homeostasis. Dysregulation of PGC-1α is correlated with the development of insulin resistance and type 2 diabetes. ZLN005 is a small molecule that has been shown to increase the mRNA level of PGC-1α in L6 myotubes in a dose-dependent manner (5 – 20μM). It leds to a threefold increase in the PGC-1α gene expression over the control group at a concentration of 20μM after 24 h. ZLN005 at 10μM increased the mRNA expressions of GLUT4, NRF1, ERRα, cox5b, and acyl-CoA oxidase. ZLN005 at 20μM resulted in a 1.8-fold improvement in glucose uptake after 24 h of treatment. Chronic oral administration of db/db mice with 15mg/kg/day ZLN005 for 6 weeks improved glucose tolerance and pyruvate tolerance, and decreased insulin resistance in comparison with the control group. ZLN005 treatment also decreased the plasma non-esterified fatty acids and triglyceride levels in db/db mice by 20% and 37%, respectively^[3].
参考文献

[1] Li W, Li X, Wang B, et al. ZLN005 protects cardiomyocytes against high glucose-induced cytotoxicity by promoting SIRT1 expression and autophagy. Exp Cell Res. 2016 Jul 1;345(1):25-36.
[2] Zhang LN, Zhou HY, et al. Novel small-molecule PGC-1α transcriptional regulator with beneficial effects on diabetic db/db mice. Diabetes. 2013 Apr;62(4):1297-307.
[3] Zhang LN, Zhou HY, Fu YY, Li YY, Wu F, Gu M, Wu LY, Xia CM, Dong TC, Li JY, Shen JK, Li J. Novel small-molecule PGC-1α transcriptional regulator with beneficial effects on diabetic db/db mice. Diabetes. 2013 Apr;62(4):1297-307.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.9946 mL
- 19.9728 mL
- 39.9457 mL
- 5 mM
- 0.7989 mL
- 3.9946 mL
- 7.9891 mL
- 10 mM
- 0.3995 mL
- 1.9973 mL
- 3.9946 mL

技术信息

CAS号

49671-76-3

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C17H18N2

运输

蓝冰

分子量

250.34

别名

ZLN005

溶解度

DMSO	37.0 mg/mL (147.8 mM)
Water	Insoluble
Ethanol	2.0 mg/mL (8.0 mM)

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